PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18229607-5 2007 Furthermore, the metabolism of neferine in rat liver microsomes showed that the percentage inhibition of the major metabolism (liensinine) formation was 80.5% by quinidine (10 micromol x L(-1), selective CYP2D1 inhibitor) and 25.7% by ketoconazole (1 micromol x L(-1), selective CYP3A1 inhibitor). liensinine 127-137 cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus 204-210 18229607-6 2007 Neferine was mainly metabolized by CYP2D1 or CYP3A1 to liensinine, isoliensinine, desmethyl-liensinine and desmethyl-isoliensinine. liensinine 55-65 cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus 35-41