PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34901018-0 2021 Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways. halofuginone 0-12 AKT serine/threonine kinase 1 Homo sapiens 80-83 34901018-7 2021 Gene expression profiling and KEGG analysis indicated that PI3K/AKT and MAPK signaling pathways were top-ranked pathways affected by halofuginone. halofuginone 133-145 AKT serine/threonine kinase 1 Homo sapiens 64-67 28013187-7 2017 To gain insight into the molecular mechanisms, we evaluated the effect of halofuginone on the MAPK and AKT pathways. halofuginone 74-86 AKT serine/threonine kinase 1 Homo sapiens 103-106 28013187-8 2017 Our results indicated that halofuginone inhibited the activity of MAPK and AKT. halofuginone 27-39 AKT serine/threonine kinase 1 Homo sapiens 75-78 28013187-9 2017 Taken together, these results suggest that halofuginone may protect against joint destruction in RA by regulating synoviocyte migration, invasion and cell proliferation by inhibiting MAPK and AKT activation. halofuginone 43-55 AKT serine/threonine kinase 1 Homo sapiens 192-195 26160839-0 2015 Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism. halofuginone 0-12 AKT serine/threonine kinase 1 Homo sapiens 70-73 26160839-2 2015 Here, we present for the first time that halofuginone (HF) treatment inhibits colorectal cancer (CRC) growth both in vitro and in vivo through regulation of Akt/mTORC1 signaling pathway. halofuginone 41-53 AKT serine/threonine kinase 1 Homo sapiens 157-160 21117034-10 2011 Recently, these halofuginone-dependent improvements were also observed in MD with minor fibrosis involvement, probably due to a direct effect of halofuginone on muscle cells, resulting in myotube fusion that is dependent on Akt and MAPK pathway activation. halofuginone 16-28 AKT serine/threonine kinase 1 Homo sapiens 224-227 21117034-10 2011 Recently, these halofuginone-dependent improvements were also observed in MD with minor fibrosis involvement, probably due to a direct effect of halofuginone on muscle cells, resulting in myotube fusion that is dependent on Akt and MAPK pathway activation. halofuginone 145-157 AKT serine/threonine kinase 1 Homo sapiens 224-227