PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29771357-6	2018	Halofuginone increased lysosome scattering across the cytosol of dysf-/- primary myoblasts, in a protein kinase/extracellular signal-regulated protein kinase and phosphoinositide 3 kinase/Akt-dependent manner, in agreement with an elevation in lysosomal exocytotic activity in these cells.	halofuginone	0-12	thymoma viral proto-oncogene 1	Mus musculus	188-191	
28492544-2	2017	Our previous study found that halofuginone (HF) exerts anticancer activity in colorectal cancer (CRC) by downregulating Akt/mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway.	halofuginone	30-42	thymoma viral proto-oncogene 1	Mus musculus	120-123	
26454207-5	2016	In cultures of myofibers and myoblasts isolated from dysf(-/-) mice, halofuginone reduced Bax and induced Bcl2 expression levels and induced Akt phosphorylation in a time-dependent manner.	halofuginone	69-81	thymoma viral proto-oncogene 1	Mus musculus	141-144	
26454207-6	2016	Addition of an inhibitor of the phosphinositide-3-kinase/Akt pathway reversed the halofuginone-induced cell survival, suggesting this pathway"s involvement in mediating halofuginone"s effects on survival.	halofuginone	82-94	thymoma viral proto-oncogene 1	Mus musculus	57-60	
26454207-6	2016	Addition of an inhibitor of the phosphinositide-3-kinase/Akt pathway reversed the halofuginone-induced cell survival, suggesting this pathway"s involvement in mediating halofuginone"s effects on survival.	halofuginone	169-181	thymoma viral proto-oncogene 1	Mus musculus	57-60	
20060825-0	2010	Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: effect on myotube fusion.	halofuginone	0-12	thymoma viral proto-oncogene 1	Mus musculus	57-60	
20060825-2	2010	Here, we demonstrate that halofuginone promotes the phosphorylation of Akt and mitogen-activated protein kinase (MAPK) family members in a C2 muscle cell line and in primary myoblasts derived from wild-type and mdx mice diaphragms.	halofuginone	26-38	thymoma viral proto-oncogene 1	Mus musculus	71-74	
20060825-3	2010	Halofuginone enhanced the association of phosphorylated Akt and MAPK/extracellular signal-regulated protein kinase (ERK) with the non-phosphorylated form of Smad3, accompanied by a reduction in Smad3 phosphorylation levels.	halofuginone	0-12	thymoma viral proto-oncogene 1	Mus musculus	56-59	
20060825-4	2010	This reduction was reversed by inhibitors of the phosphoinositide 3"-kinase/Akt (PI3K/Akt) and MAPK/ERK pathways, suggesting their specific role in mediating halofuginone"s inhibitory effect on Smad3 phosphorylation.	halofuginone	158-170	thymoma viral proto-oncogene 1	Mus musculus	76-79	
20060825-5	2010	Halofuginone enhanced Akt, MAPK/ERK and p38 MAPK phosphorylation and inhibited Smad3 phosphorylation in myotubes, all of which are crucial for myotube fusion.	halofuginone	0-12	thymoma viral proto-oncogene 1	Mus musculus	22-25	
20060825-6	2010	In addition, halofuginone increased the association Akt and MAPK/ERK with Smad3.	halofuginone	13-25	thymoma viral proto-oncogene 1	Mus musculus	52-55	
20060825-8	2010	Together, the data suggest a role, either direct or via inhibition of Smad3 phosphorylation, for Akt or MAPK/ERK in halofuginone-enhanced myotube fusion, a feature which is crucial to improving muscle function in muscular dystrophies.	halofuginone	116-128	thymoma viral proto-oncogene 1	Mus musculus	97-100