PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21615395-7 2011 Treatment of myotubes with a selective high-affinity PPARdelta agonist (GW501516) did not change mean PPARD, but enhanced mean PDK4 and ANGPTL4 expression 13- and 16-fold, respectively (P < 0 0001, both). GW 501516 72-80 pyruvate dehydrogenase kinase 4 Homo sapiens 127-131 17500064-8 2007 Concomitant with these metabolic changes, we provide evidence that GW501516 increases the expression of key genes involved in lipid metabolism (FABP3, CPT1, and PDK4) by a PPARdelta-dependent mechanism. GW 501516 67-75 pyruvate dehydrogenase kinase 4 Homo sapiens 161-165 21615395-8 2011 The individual PDK4 and ANGPTL4 expression levels reached upon GW501516 treatment were associated with donors" insulin sensitivity neither (P > 0 2, both). GW 501516 63-71 pyruvate dehydrogenase kinase 4 Homo sapiens 15-19 21615395-9 2011 However, GW501516-mediated fold increments in PDK4 and ANGPTL4 expression, reflecting PPARdelta responsiveness, were positively associated with donors" insulin sensitivity derived from OGTT (P = 0 0182 and P = 0 0231, respectively) and hyperinsulinemic-euglycemic clamp (P = 0 0046 and P = 0 0258, respectively). GW 501516 9-17 pyruvate dehydrogenase kinase 4 Homo sapiens 46-50