PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21664904-4 2011 Pretreatment with levosimendan reversed the effects of ischaemia and ischaemia/reperfusion on cell viability and enhanced phosphorylation of Akt, p38-mitogen activated protein kinase (MAPK) and extracellular signal-regulated kinases 1/2 (ERK1/2). Simendan 18-30 mitogen-activated protein kinase 3 Homo sapiens 238-244 21664904-6 2011 Levosimendan stimulated the phosphorylation of Akt, ERK1/2 and p38-MAPK with different kinetics and the activation of these pathways was dependent on the opening of the mitochondrial K(ATP) channels and the production of oxygen free radicals. Simendan 0-12 mitogen-activated protein kinase 3 Homo sapiens 52-58 21664904-7 2011 The levosimendan-induced phosphorylation of ERK1/2 and Akt was reduced by inhibitors of epidermal growth factor receptor and Src. Simendan 4-16 mitogen-activated protein kinase 3 Homo sapiens 44-50 21237146-13 2011 The significant increase in the activity of prosurvival mediators ERK 1/2 and P38 following hypoxia indicates a potential mechanism of action for levosimendan-induced cardioprotection. Simendan 146-158 mitogen-activated protein kinase 3 Homo sapiens 66-73