PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8758928-0 1996 Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells. Alitretinoin 66-85 BCL2 apoptosis regulator Homo sapiens 133-138 12189556-3 2002 An involvement of the Bcl-2 family of proteins was shown, such that 9-cis-retinoic acid causes a decrease in the Bcl-2/Bax ratio. Alitretinoin 68-87 BCL2 apoptosis regulator Homo sapiens 22-27 12189556-3 2002 An involvement of the Bcl-2 family of proteins was shown, such that 9-cis-retinoic acid causes a decrease in the Bcl-2/Bax ratio. Alitretinoin 68-87 BCL2 apoptosis regulator Homo sapiens 113-118 12189556-4 2002 Overexpression of Bcl-2 also resulted in inhibition of apoptosis induced by 9-cis-retinoic acid. Alitretinoin 76-95 BCL2 apoptosis regulator Homo sapiens 18-23 12063559-13 2002 These data demonstrate that ATRA and 9cisRA may inhibit HER-2/neu induced aberrant proliferation in part by retarding cell cycle progression, down-regulating HER-2/neu-mediated signal transduction and inducing Bcl-2-dependent apoptosis through a retinoid receptor-mediated mechanism. Alitretinoin 37-43 BCL2 apoptosis regulator Homo sapiens 210-215 10738115-9 2000 Interestingly, 9-cis-RA induced transiently the expression of p21(Waf1/Cip1), p27(Kip1), p300, CBP, BAX, Bak and bcl-2 proteins, respectively. Alitretinoin 15-23 BCL2 apoptosis regulator Homo sapiens 113-118