PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25310209-6 2014 The diagnosis of BPDCN is based on the characteristic cytology and immunophenotype of malignant cells coexpressing CD4, CD56, CD123, blood dendritic cell antigens 2 and 4, and CD2AP markers. bpdcn 17-22 neural cell adhesion molecule 1 Homo sapiens 120-124 25779340-8 2015 However, we demonstrated that BPDCN is closer to CD56(+) DCs than pDCs by global gene-expression profiling. bpdcn 30-35 neural cell adhesion molecule 1 Homo sapiens 49-53 23940084-8 2013 In conclusion, BPDCN in the bone marrow has a characteristic immunoprofile (CD4+, CD56+, CD123+, and TCL-1+) and appears to be commonly associated with myelodysplastic features and a high frequency of TET2 mutations in the absence of other mutations commonly observed in AML. bpdcn 15-20 neural cell adhesion molecule 1 Homo sapiens 82-86 25120824-7 2014 According to skin biopsy, the tumor cells reveal an immature blastic appearance and positive for CD4 and CD56, negative for CD3, CD20, indicating a diagnosis of BPDCN. bpdcn 161-166 neural cell adhesion molecule 1 Homo sapiens 105-109 24390220-7 2014 BPDCN was associated with positive staining for CD56, TdT, or TCL1, or negative staining for lysozyme. bpdcn 0-5 neural cell adhesion molecule 1 Homo sapiens 48-52 22241735-9 2013 BPDCN should be strongly considered during the differential diagnosis of CD56-positive neoplasms of the skin. bpdcn 0-5 neural cell adhesion molecule 1 Homo sapiens 73-77 24312342-3 2013 However, BPDCN can be distinguished from pDCs by uniform expression of CD56. bpdcn 9-14 neural cell adhesion molecule 1 Homo sapiens 71-75 21701157-2 2011 We present a case of an 80-year-old man with a CD4+CD56+ BPDCN that affected the orbital cavity and bone marrow. bpdcn 57-62 neural cell adhesion molecule 1 Homo sapiens 51-55 22915052-3 2012 Flow cytometry study identified a cell population CD4+/CD56+/CD45RA+/CD123+/TCL1+ suggestive of BPDCN diagnosis, which was confirmed by a lymph node biopsy (cells positive for BCL11a, BDCA-2, CD2AP, CD123, TCL1 and S100). bpdcn 96-101 neural cell adhesion molecule 1 Homo sapiens 55-59 19793612-5 2010 Immunophenotyping of typical BPDCN cases revealed CD4(+), CD56(+), HLA-DR(+) and CD123(bright) neoplastic cells, in the absence of major B-, T- and myeloid-associated markers, while the phenotype of the four cases characterized as LAL highlights the risk of misdiagnosis. bpdcn 29-34 neural cell adhesion molecule 1 Homo sapiens 58-62 29660158-6 2018 Here, we report the case of a 61-year-old woman who presented with an AML with MLL rearrangement and CD4+/CD56+ expression presenting as LC and that was misdiagnosed as BPDCN. bpdcn 169-174 neural cell adhesion molecule 1 Homo sapiens 106-110 32241840-9 2021 In summary, by understanding the immunophenotype of reactive and neoplastic PDCs, BPDCN can be effectively detected by flow cytometry to a very low level using a panel of markers in addition to CD56, and such assay can be used for initial bone marrow workup as well as MRD detection after therapy. bpdcn 82-87 neural cell adhesion molecule 1 Homo sapiens 194-198 35171796-8 2022 Immunohistochemically, CD4, CD56, CD123 and TCL-1 were positive in 82.1%, 92.9%, 96.0% and 100% cases of BPDCN, respectively. bpdcn 105-110 neural cell adhesion molecule 1 Homo sapiens 28-32 27913457-4 2016 BPDCN is most easily defined by the phenotype CD4+CD56+CD123+lineage-MPO-, although many patients will present with variable expression of CD4, CD56, or alternate plasmacytoid markers, which compounds the difficulty in differentiating BPDCN from other myeloid or lymphoid malignancies. bpdcn 0-5 neural cell adhesion molecule 1 Homo sapiens 50-54