PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26593430-0 2015 Farrerol can attenuate the aortic lesion in spontaneously hypertensive rats via the upregulation of eNOS and reduction of NAD(P)H oxidase activity. farrerol 0-8 nitric oxide synthase 3 Rattus norvegicus 100-104 26593430-5 2015 Moreover, the levels of O2(-) along with NAD(P)H oxidase activity were reduced (P<0.05), while the activity of endothelial nitric oxide synthase (eNOS) was elevated (P<0.05) in aortic homogenates after the intervention of farrerol. farrerol 228-236 nitric oxide synthase 3 Rattus norvegicus 114-147 26593430-5 2015 Moreover, the levels of O2(-) along with NAD(P)H oxidase activity were reduced (P<0.05), while the activity of endothelial nitric oxide synthase (eNOS) was elevated (P<0.05) in aortic homogenates after the intervention of farrerol. farrerol 228-236 nitric oxide synthase 3 Rattus norvegicus 149-153 26593430-6 2015 Furthermore, farrerol upregulated the expression of eNOS in both of mRNA and protein levels, accompanied by the downregulated mRNA and protein expression of p22(phox) (P<0.05), an essential subunit for NADPH oxidase activity. farrerol 13-21 nitric oxide synthase 3 Rattus norvegicus 52-56 26593430-7 2015 Our findings indicated that farrerol has a significant protective effect against the aortic lesion in SHR, which may be related to the enhanced eNOS activity and reduced NAD(P)H oxidase activity. farrerol 28-36 nitric oxide synthase 3 Rattus norvegicus 144-148