PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32082480-0	2020	Farrerol Directly Targets GSK-3beta to Activate Nrf2-ARE Pathway and Protect EA.hy926 Cells against Oxidative Stress-Induced Injuries.	farrerol	0-8	glycogen synthase kinase 3 alpha	Homo sapiens	26-35	
32082480-5	2020	Our results demonstrated that farrerol could specifically target Nrf2 negative regulator GSK-3beta and inhibit its kinase activity.	farrerol	30-38	glycogen synthase kinase 3 alpha	Homo sapiens	89-98	
32082480-6	2020	Mechanistic studies proved that farrerol could induce an inhibitory phosphorylation of GSK-3beta at Ser9 without affecting the expression level of total GSK-3beta protein and promote the nuclear translocation of Nrf2 as well as the mRNA and protein expression of its downstream target genes heme oxygenase-1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO1) in EA.hy926 cells.	farrerol	32-40	glycogen synthase kinase 3 alpha	Homo sapiens	87-96	
32082480-7	2020	Further studies performed with GSK-3beta siRNA and specific inhibitor lithium chloride (LiCl) confirmed that GSK-3beta inhibition was involved in farrerol-mediated endothelial protection and Nrf2 signaling activation.	farrerol	146-154	glycogen synthase kinase 3 alpha	Homo sapiens	31-40	
32082480-7	2020	Further studies performed with GSK-3beta siRNA and specific inhibitor lithium chloride (LiCl) confirmed that GSK-3beta inhibition was involved in farrerol-mediated endothelial protection and Nrf2 signaling activation.	farrerol	146-154	glycogen synthase kinase 3 alpha	Homo sapiens	109-118	
32082480-8	2020	Moreover, molecular docking and molecular dynamics studies revealed that farrerol could bind to the ATP pocket of GSK-3beta, which is consistent with the ATP-competitive kinetic behavior.	farrerol	73-81	glycogen synthase kinase 3 alpha	Homo sapiens	114-123	
32082480-9	2020	Collectively, our results firstly demonstrate that farrerol could attenuate endothelial oxidative stress by specifically targeting GSK-3beta and further activating the Nrf2-ARE signaling pathway.	farrerol	51-59	glycogen synthase kinase 3 alpha	Homo sapiens	131-140