PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15056799-11	2004	Our results suggest that indirubin rapidly activates its own metabolism via AhR-mediated induction of CYP1A1 and this characteristic is consistent with the notion that indirubin is a physiological ligand of AhR.	indirubin	25-34	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	102-108	
15056799-11	2004	Our results suggest that indirubin rapidly activates its own metabolism via AhR-mediated induction of CYP1A1 and this characteristic is consistent with the notion that indirubin is a physiological ligand of AhR.	indirubin	168-177	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	102-108	
14637189-4	2003	We determined the effect of indirubin in MCF-7 breast cancer cells on induction of the activities of cytochromes P450 (CYP) 1A1 and 1B1, as measured by estradiol and ethoxyresorufin metabolism, and on induction of the CYP1A1 and CYP1B1 mRNAs.	indirubin	28-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	101-135	
14637189-4	2003	We determined the effect of indirubin in MCF-7 breast cancer cells on induction of the activities of cytochromes P450 (CYP) 1A1 and 1B1, as measured by estradiol and ethoxyresorufin metabolism, and on induction of the CYP1A1 and CYP1B1 mRNAs.	indirubin	28-37	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	218-224	
14637189-8	2003	Indirubin was metabolized by microsomes containing cDNA-expressed human CYP1A1 or CYP1B1.	indirubin	0-9	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	72-78	
14637189-10	2003	Thus, if indirubin is an endogenous AhR ligand, then AhR-mediated signaling by indirubin is likely to be transient and tightly controlled by the ability of indirubin to induce CYP1A1 and CYP1B1, and hence its own metabolism.	indirubin	9-18	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	176-182	
35458697-4	2022	The methanolic ROE was further assayed towards CYP1A1 mRNA induction using RT-PCR in human keratinocytes against TCDD, FICZ, PZ, and IND.	indirubin	133-136	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	47-53