PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16702956-1 2006 Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the aryl hydrocarbon receptor (AhR). indirubin 0-9 aryl hydrocarbon receptor Homo sapiens 159-184 22533375-2 2012 The production of potent AhR ligands by Malassezia yeasts, such as indirubin, indolo[3,2-b]carbazole (ICZ), tryptanthrin and malassezin, has been associated with the pathogenesis of seborrhoeic dermatitis and pityriasis versicolor. indirubin 67-76 aryl hydrocarbon receptor Homo sapiens 25-28 20565777-6 2010 All indirubins used in the present study are potent agonists of the aryl hydrocarbon receptor (AhR), which is known for its important role in the cellular metabolism of xenobiotics. indirubin 4-14 aryl hydrocarbon receptor Homo sapiens 68-93 20565777-6 2010 All indirubins used in the present study are potent agonists of the aryl hydrocarbon receptor (AhR), which is known for its important role in the cellular metabolism of xenobiotics. indirubin 4-14 aryl hydrocarbon receptor Homo sapiens 95-98 20565777-12 2010 CONCLUSIONS: Our results indicate that continued expression of endogenous AhR promotes centrosome amplification in breast cancer cells in a pathway that involves cyclin E. AhR agonists such as indirubins inhibit centrosome amplification even when stimulated by ectopic expression of the AhR suggesting that these compounds are potentially useful for the chemoprevention of centrosome-mediated cell division errors and malignant progression in neoplasms in which the AhR is overexpressed. indirubin 193-203 aryl hydrocarbon receptor Homo sapiens 74-77 20565777-12 2010 CONCLUSIONS: Our results indicate that continued expression of endogenous AhR promotes centrosome amplification in breast cancer cells in a pathway that involves cyclin E. AhR agonists such as indirubins inhibit centrosome amplification even when stimulated by ectopic expression of the AhR suggesting that these compounds are potentially useful for the chemoprevention of centrosome-mediated cell division errors and malignant progression in neoplasms in which the AhR is overexpressed. indirubin 193-203 aryl hydrocarbon receptor Homo sapiens 172-175 20565777-12 2010 CONCLUSIONS: Our results indicate that continued expression of endogenous AhR promotes centrosome amplification in breast cancer cells in a pathway that involves cyclin E. AhR agonists such as indirubins inhibit centrosome amplification even when stimulated by ectopic expression of the AhR suggesting that these compounds are potentially useful for the chemoprevention of centrosome-mediated cell division errors and malignant progression in neoplasms in which the AhR is overexpressed. indirubin 193-203 aryl hydrocarbon receptor Homo sapiens 172-175 20565777-12 2010 CONCLUSIONS: Our results indicate that continued expression of endogenous AhR promotes centrosome amplification in breast cancer cells in a pathway that involves cyclin E. AhR agonists such as indirubins inhibit centrosome amplification even when stimulated by ectopic expression of the AhR suggesting that these compounds are potentially useful for the chemoprevention of centrosome-mediated cell division errors and malignant progression in neoplasms in which the AhR is overexpressed. indirubin 193-203 aryl hydrocarbon receptor Homo sapiens 172-175 16702956-1 2006 Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the aryl hydrocarbon receptor (AhR). indirubin 0-9 aryl hydrocarbon receptor Homo sapiens 186-189 34280616-2 2021 We reported previously that 3-methylcholanthrene (3MC), an exogenous AhR agonist, inhibited tumorsphere (mammosphere) formation from breast cancer cell lines, while the endogenous AhR agonist, indirubin, very weakly inhibited this process. indirubin 193-202 aryl hydrocarbon receptor Homo sapiens 180-183 15056799-11 2004 Our results suggest that indirubin rapidly activates its own metabolism via AhR-mediated induction of CYP1A1 and this characteristic is consistent with the notion that indirubin is a physiological ligand of AhR. indirubin 25-34 aryl hydrocarbon receptor Homo sapiens 76-79 15056799-11 2004 Our results suggest that indirubin rapidly activates its own metabolism via AhR-mediated induction of CYP1A1 and this characteristic is consistent with the notion that indirubin is a physiological ligand of AhR. indirubin 25-34 aryl hydrocarbon receptor Homo sapiens 207-210 15056799-11 2004 Our results suggest that indirubin rapidly activates its own metabolism via AhR-mediated induction of CYP1A1 and this characteristic is consistent with the notion that indirubin is a physiological ligand of AhR. indirubin 168-177 aryl hydrocarbon receptor Homo sapiens 76-79 15056799-11 2004 Our results suggest that indirubin rapidly activates its own metabolism via AhR-mediated induction of CYP1A1 and this characteristic is consistent with the notion that indirubin is a physiological ligand of AhR. indirubin 168-177 aryl hydrocarbon receptor Homo sapiens 207-210 15077192-0 2004 Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. indirubin 119-129 aryl hydrocarbon receptor Homo sapiens 52-77 15077192-10 2004 Altogether these results suggest that AhR activation, rather than kinase inhibition, is responsible for the cytostatic effects of some indirubins. indirubin 135-145 aryl hydrocarbon receptor Homo sapiens 38-41 14637189-10 2003 Thus, if indirubin is an endogenous AhR ligand, then AhR-mediated signaling by indirubin is likely to be transient and tightly controlled by the ability of indirubin to induce CYP1A1 and CYP1B1, and hence its own metabolism. indirubin 9-18 aryl hydrocarbon receptor Homo sapiens 36-39 14637189-10 2003 Thus, if indirubin is an endogenous AhR ligand, then AhR-mediated signaling by indirubin is likely to be transient and tightly controlled by the ability of indirubin to induce CYP1A1 and CYP1B1, and hence its own metabolism. indirubin 9-18 aryl hydrocarbon receptor Homo sapiens 53-56 34969665-2 2021 Indigo and indirubin, its main constituents, are ligands of the aryl hydrocarbon receptor (AhR). indirubin 11-20 aryl hydrocarbon receptor Homo sapiens 64-89 34969665-2 2021 Indigo and indirubin, its main constituents, are ligands of the aryl hydrocarbon receptor (AhR). indirubin 11-20 aryl hydrocarbon receptor Homo sapiens 91-94 35169210-0 2022 Synergistic effect of plasma-activated medium and novel indirubin derivatives on human skin cancer cells by activation of the AhR pathway. indirubin 56-65 aryl hydrocarbon receptor Homo sapiens 126-129 35458697-2 2022 Hence, it would be very important to identify natural compounds that could inhibit the AhR activation by ligands of microbial origin as 6-formylindolo(3,2-b)carbazole (FICZ), indirubin (IND) and pityriazepin (PZ) or the prototype ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). indirubin 175-184 aryl hydrocarbon receptor Homo sapiens 87-90 35458697-2 2022 Hence, it would be very important to identify natural compounds that could inhibit the AhR activation by ligands of microbial origin as 6-formylindolo(3,2-b)carbazole (FICZ), indirubin (IND) and pityriazepin (PZ) or the prototype ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). indirubin 186-189 aryl hydrocarbon receptor Homo sapiens 87-90 35458697-9 2022 ROEs inhibit AhR activation by TCDD and by the Malassezia metabolites FICZ, PZ, and IND. indirubin 84-87 aryl hydrocarbon receptor Homo sapiens 13-16 35288632-0 2022 Publisher Correction: Synergistic effect of plasma-activated medium and novel indirubin derivatives on human skin cancer cells by activation of the AhR pathway. indirubin 78-87 aryl hydrocarbon receptor Homo sapiens 148-151 35169210-7 2022 I3M had a pro-apoptotic effect only in A431 cells, so we hypothesize a different mode of action of the indirubin derivatives in the two skin cancer cells, possibly due to a different level of the aryl hydrocarbon receptor and an activation of this pathway by nuclear translocation of this receptor and subsequent activation of gene expression. indirubin 103-112 aryl hydrocarbon receptor Homo sapiens 196-221 31505164-5 2019 Studies indicate that select indirubin derivatives bind and activate signaling of the AHR pathway, as well as inhibit cyclin-dependent kinases and STAT3 signaling. indirubin 29-38 aryl hydrocarbon receptor Homo sapiens 86-89 26416282-6 2015 AHR target gene expression was further enhanced by exogenous kynurenine, and exogenous tryptophan, kynurenine, or synthetic agonist indirubin reduced mycobacterial viability. indirubin 132-141 aryl hydrocarbon receptor Homo sapiens 0-3 31796845-3 2019 Indirubin exerts its biological functions via two xenobiotic receptor systems: aryl hydrocarbon receptor (AHR) and pregnane X receptor (PXR); however, its effects on wound healing remain elusive. indirubin 0-9 aryl hydrocarbon receptor Homo sapiens 79-104 31796845-3 2019 Indirubin exerts its biological functions via two xenobiotic receptor systems: aryl hydrocarbon receptor (AHR) and pregnane X receptor (PXR); however, its effects on wound healing remain elusive. indirubin 0-9 aryl hydrocarbon receptor Homo sapiens 106-109 30201897-3 2018 While the AhR agonist indirubin (IR) is a more potent activator of hAhR-dependent gene expression than the prototypical ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), it is a significantly less potent activator of the mAhR. indirubin 22-31 aryl hydrocarbon receptor Homo sapiens 10-13 30201897-3 2018 While the AhR agonist indirubin (IR) is a more potent activator of hAhR-dependent gene expression than the prototypical ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), it is a significantly less potent activator of the mAhR. indirubin 22-31 aryl hydrocarbon receptor Homo sapiens 67-71