PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31505164-5	2019	Studies indicate that select indirubin derivatives bind and activate signaling of the AHR pathway, as well as inhibit cyclin-dependent kinases and STAT3 signaling.	indirubin	29-38	signal transducer and activator of transcription 3	Homo sapiens	147-152	
26386687-6	2015	Furthermore, we demonstrate that E804 reduces signal transducer and activator of transcription-3 (Stat3) signaling to a remarkable extent, suggesting that inactivation of Stat3, at least in part, mediates the effects of this indirubin derivative.	indirubin	225-234	signal transducer and activator of transcription 3	Homo sapiens	46-96	
26386687-6	2015	Furthermore, we demonstrate that E804 reduces signal transducer and activator of transcription-3 (Stat3) signaling to a remarkable extent, suggesting that inactivation of Stat3, at least in part, mediates the effects of this indirubin derivative.	indirubin	225-234	signal transducer and activator of transcription 3	Homo sapiens	98-103	
26386687-6	2015	Furthermore, we demonstrate that E804 reduces signal transducer and activator of transcription-3 (Stat3) signaling to a remarkable extent, suggesting that inactivation of Stat3, at least in part, mediates the effects of this indirubin derivative.	indirubin	225-234	signal transducer and activator of transcription 3	Homo sapiens	171-176	
22554053-1	2012	BACKGROUND: It has previously been shown that indirubin derivative E804 (IDR-E804) blocks signal transducer and activator of transcription-3 signaling in human breast and prostate cancer cells and inhibits Src kinase activity.	indirubin	46-55	signal transducer and activator of transcription 3	Homo sapiens	90-140	
17341611-5	2006	Besides small peptides and oligonucleotides, numerous small molecules have been identified as blockers of STAT3 activation, including synthetic molecules (e.g., AG 490, decoy peptides, and oligonucleotides) and plant polyphenols (e.g., curcumin, resveratrol, flavopiridol, indirubin, magnolol, piceatannol, parthenolide, EGCG, and cucurbitacin).	indirubin	273-282	signal transducer and activator of transcription 3	Homo sapiens	106-111	
15837920-8	2005	These results demonstrate that E804 directly blocks the Src-Stat3 signaling pathway, suggesting that the antitumor activity of indirubin compounds is at least partially due to inhibition of this pathway.	indirubin	127-136	signal transducer and activator of transcription 3	Homo sapiens	60-65