PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32200503-0 2020 CUDC-907 enhances TRAIL-induced apoptosis through upregulation of DR5 in breast cancer cells. CUDC-907 0-8 TNF receptor superfamily member 10b Homo sapiens 66-69 32200503-7 2020 Knockdown of DR5 abrogated apoptosis induced by the combination of CUDC-907 and TRAIL in breast cancer cells. CUDC-907 67-75 TNF receptor superfamily member 10b Homo sapiens 13-16 32200503-9 2020 JNK inhibitor pretreatment attenuated CUDC-907-induced upregulation of DR5. CUDC-907 38-46 TNF receptor superfamily member 10b Homo sapiens 71-74 32200503-10 2020 In summary, CUDC-907 shows potent cytotoxicity against breast cancer cells and facilitates TRAIL-mediated apoptosis through DR5 upregulation. CUDC-907 12-20 TNF receptor superfamily member 10b Homo sapiens 124-127 32200503-6 2020 CUDC-907 enhanced expressions of death receptor 5 (DR5), reduced the levels of anti-apoptotic molecules XIAP, Bcl-2 and Bcl-xL. CUDC-907 0-8 TNF receptor superfamily member 10b Homo sapiens 33-49 32200503-6 2020 CUDC-907 enhanced expressions of death receptor 5 (DR5), reduced the levels of anti-apoptotic molecules XIAP, Bcl-2 and Bcl-xL. CUDC-907 0-8 TNF receptor superfamily member 10b Homo sapiens 51-54