PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21961053-3	2011	CDDO-Me inhibited the growth of murine TRAMPC-1 prostate cancer cells by inducing apoptosis through the inhibition of antiapoptotic p-Akt, p-mTOR and NF-kappaB.	bardoxolone methyl	0-7	thymoma viral proto-oncogene 1	Mus musculus	134-137	
21961053-7	2011	Treatment with CDDO-Me inhibited the expression of prosurvival p-Akt and NF-kappaB in the prostate and knocking-down Akt in TRAMPC-1 tumor cells sensitized them to CDDO-Me.	bardoxolone methyl	15-22	thymoma viral proto-oncogene 1	Mus musculus	65-68	
21961053-7	2011	Treatment with CDDO-Me inhibited the expression of prosurvival p-Akt and NF-kappaB in the prostate and knocking-down Akt in TRAMPC-1 tumor cells sensitized them to CDDO-Me.	bardoxolone methyl	15-22	thymoma viral proto-oncogene 1	Mus musculus	117-120	
21961053-8	2011	These findings indicated that Akt is a target for apoptoxicity in TRAMPC-1 cells in vitro and potentially a target of CDDO-Me for inhibition of prostate cancer in vivo.	bardoxolone methyl	118-125	thymoma viral proto-oncogene 1	Mus musculus	30-33	
25047252-3	2014	Since the synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1,9-dien-28-oate (CDDO-Me) has been shown to inhibit AKT, MEK-1/2, and NF-kappaB, and to induce caspase-mediated apoptosis, we tested the therapeutic potential of this agent in murine lupus nephritis.	bardoxolone methyl	83-90	thymoma viral proto-oncogene 1	Mus musculus	118-121	
18472640-0	2008	CDDO-Me inhibits proliferation, induces apoptosis, down-regulates Akt, mTOR, NF-kappaB and NF-kappaB-regulated antiapoptotic and proangiogenic proteins in TRAMP prostate cancer cells.	bardoxolone methyl	0-7	thymoma viral proto-oncogene 1	Mus musculus	66-69	
17483332-7	2007	In vitro, after treatment of 4T1 cells with 500 nmol/L CDDO-Me for 2 h, we found (a) inactivation of STAT3, (b) inactivation of Src and Akt, (c) 4-fold reduction of c-Myc mRNA levels, (d) accumulation of cells in G(2)-M cell cycle phase, (e) abrogation of invasive growth of 4T1 cells, and (f) lack of apoptosis induction.	bardoxolone methyl	55-62	thymoma viral proto-oncogene 1	Mus musculus	136-139