PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18413761-0	2008	Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3.	bardoxolone methyl	13-30	Janus kinase 1	Homo sapiens	70-74	
18413761-0	2008	Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3.	bardoxolone methyl	13-30	Janus kinase 1	Homo sapiens	172-176	
18413761-3	2008	The present studies show that CDDO-Me blocks interleukin-6 (IL-6)-induced and constitutive activation of the Janus-activated kinase 1 (JAK1) in cells.	bardoxolone methyl	30-37	Janus kinase 1	Homo sapiens	109-133	
18413761-3	2008	The present studies show that CDDO-Me blocks interleukin-6 (IL-6)-induced and constitutive activation of the Janus-activated kinase 1 (JAK1) in cells.	bardoxolone methyl	30-37	Janus kinase 1	Homo sapiens	135-139	
18413761-4	2008	In support of a direct mechanism, CDDO-Me forms adducts with JAK1 at Cys(1077) in the kinase domain and inhibits JAK1 activity.	bardoxolone methyl	34-41	Janus kinase 1	Homo sapiens	61-65	
18413761-4	2008	In support of a direct mechanism, CDDO-Me forms adducts with JAK1 at Cys(1077) in the kinase domain and inhibits JAK1 activity.	bardoxolone methyl	34-41	Janus kinase 1	Homo sapiens	113-117	
18413761-7	2008	These findings indicate that CDDO-Me inhibits activation of the JAK1-->STAT3 pathway by forming adducts with both JAK1 and STAT3.	bardoxolone methyl	29-36	Janus kinase 1	Homo sapiens	64-68	
18413761-7	2008	These findings indicate that CDDO-Me inhibits activation of the JAK1-->STAT3 pathway by forming adducts with both JAK1 and STAT3.	bardoxolone methyl	29-36	Janus kinase 1	Homo sapiens	117-121