PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33404239-3 2021 Herein, we report the discovery of a potent and novel OGA inhibitor, compound 5i, comprising an aminopyrimidine scaffold, identified by virtual screening based on multiple methodologies combining structure-based and ligand-based approaches, followed by sequential optimization with a focus on ligand lipophilicity efficiency. 2-aminopyrimidine 96-111 O-GlcNAcase Homo sapiens 54-57