PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19267349-2	2009	After castration, or removal of testicular androgens, CYP17A1 can act as a rate-limiting enzyme in androgen synthesis from cholesterol or other adrenal precursors within the tumor microenvironment ultimately contributing to disease progression.	Cholesterol	123-134	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	54-61	
19497978-2	2009	Cholesterol side-chain cleavage (CYP11A1) and 17alpha-hydroxylase/17,20-lyase (CYP17) metabolize cholesterol into DHEA, whereas steroid sulfotransferase family 2A1 (SULT2A1) is responsible for conversion of DHEA to DHEA sulfate.	Cholesterol	0-11	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	79-84	
19497978-2	2009	Cholesterol side-chain cleavage (CYP11A1) and 17alpha-hydroxylase/17,20-lyase (CYP17) metabolize cholesterol into DHEA, whereas steroid sulfotransferase family 2A1 (SULT2A1) is responsible for conversion of DHEA to DHEA sulfate.	Cholesterol	97-108	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	79-84	
18499961-5	2008	Two of the candidate genes are the CYP17 and the CYP11alpha, encoding the 17-alpha-hydroxylase (P45017alpha) and the cholesterol side chain cleavage (P450scc) respectively.	Cholesterol	117-128	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	35-40	
9768686-4	1998	After conversion of cholesterol to pregnenolone, 17alpha-hydroxylase/17,20-lyase (CYP17) can metabolize pregnenolone through to DHEA.	Cholesterol	20-31	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	82-87	
8964847-1	1996	Previous studies of human adrenocortical cells have given inconsistent findings concerning the effects of angiotensin II (AII) alone or in combination with activators of the protein kinase A-signaling pathway on expression of cholesterol side-chain cleavage cytochrome P450 (P450scc), 17 alpha-hydroxylase cytochrome P450 (P450c17), and 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), as well as the corresponding effects on adrenocortical cell steroid secretory products.	Cholesterol	226-237	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	323-330	
34333840-3	2021	Abiraterone acetate blocks CYP17A1, which reduces testosterone synthesis from adrenal androgens or cholesterol in the testis, adrenal glands, and prostate cancer cells (2).	Cholesterol	99-110	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	27-34	
7588323-4	1995	This action of K+ was accompanied by a dose-dependent (P < 0.05 at 6 mM K+ or above) and time-dependent (P < 0.05 at 24 h and beyond) increase in expression of P450c17 and, to a lesser extent, cytochrome P450 cholesterol side-chain cleavage messenger RNA (mRNA).	Cholesterol	215-226	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	166-173	
8396578-11	1993	IGF-II increased the abundance of ACTH-stimulated mRNAs encoding cholesterol side-chain cleavage cytochrome P450 (P450scc), 17 alpha hydroxylase/17,20 lyase P450 (P450c17), and 3 beta-hydroxysteroid dehydrogenase (3 beta HSD).	Cholesterol	65-76	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	163-170	
33750894-3	2021	Steroidogenic enzymes, such as CYP11A1, CYP17A1, HSD3B1, AKR1C3 and SRD5A, are essential to catalyze the conversion of the initial substrate cholesterol into potent androgens that confers the CRPC progression.	Cholesterol	141-152	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	40-47	
2555382-7	1989	Increased P450scc activity, which increased the conversion of cholesterol to pregnenolone, apparently permitted the 17,20-lyase activity of P450c17 to become rate limiting, thus accounting for the increased secretion of 17OHP.	Cholesterol	62-73	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	140-147	
34041015-5	2021	Based on documentary investigation, we postulated that the AR-SCAP-SREBPs-CYP17/HMGCR axis may regulate cholesterol and androgens synthesis and form a positive enhancement loop promoting NB progression.	Cholesterol	104-115	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	74-79	
24584631-1	2014	Carbon-carbon bond cleavage reactions are catalyzed by, among others, lanosterol 14-demethylase (CYP51), cholesterol side-chain cleavage enzyme (CYP11), sterol 17beta-lyase (CYP17), and aromatase (CYP19).	Cholesterol	105-116	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	174-179	
26514241-3	2016	The biosynthesis of cortisol involves a cascade of cholesterol metabolizing reactions regulated through three major CYP proteins: 17alpha-hydroxylase-C17/20-lyase (CYP17), 21-hydroxylase (CYP21), and 11beta-hydroxylase (CYP11B1).	Cholesterol	51-62	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	164-169	
25334044-6	2014	The mRNA levels of a cholesterol transport protein required for all steroidogenesis, StAR, and steroidogenic enzymes, HSD3beta2, CYP11A1, CYP21A2, and CYP17A1 increased 1.2-2.1-fold in GIP-stimulated H295R-GIPR cells.	Cholesterol	21-32	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	151-158	
24759590-4	2014	CYP17 is necessary for production of nongonadal androgens from cholesterol.	Cholesterol	63-74	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	0-5	
22174412-1	2012	TOK-001 and abiraterone are potent 17-heteroarylsteroid (17-HAS) inhibitors of Cyp17, one of the rate-limiting enzymes in the biosynthesis of testosterone from cholesterol in prostate cancer cells.	Cholesterol	160-171	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	79-84	
22451619-1	2012	Abiraterone acetate is an orally administered potent inhibitor of cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17), which is essential for synthesis of testosterone from cholesterol.	Cholesterol	184-195	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	66-120	
22451619-1	2012	Abiraterone acetate is an orally administered potent inhibitor of cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17), which is essential for synthesis of testosterone from cholesterol.	Cholesterol	184-195	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	122-127	
22649409-1	2012	Dehydroepiandrosterone (DHEA) is synthesized from cholesterol by activity of P450scc and P450c17, enzymes that we previously characterized in the developing nervous system.	Cholesterol	50-61	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	89-96