PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25520222-1	2014	OBJECTIVE: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors including rosuvastatin do not only lower plasma cholesterol but also have non-cholesterol lowering effects on the vessel wall, which decrease cardiovascular complications.	Cholesterol	128-139	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	11-68	
24952770-16	2014	The mRNA abundance of genes involved in cholesterol synthesis (SREBF-2, HMGCS1, and HMGCR) markedly increased from wk 3 a.p.	Cholesterol	40-51	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	84-89	
25520222-1	2014	OBJECTIVE: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors including rosuvastatin do not only lower plasma cholesterol but also have non-cholesterol lowering effects on the vessel wall, which decrease cardiovascular complications.	Cholesterol	158-169	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	11-68	
9237044-2	1997	Cholesterol-poor BAEC were obtained by treating the cells with 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors under 10% low density lipoprotein (LDL)-deficient serum condition for 2 days.	Cholesterol	0-11	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	63-120	
34755854-15	2021	Selenium supplementation with different sources and concentrations has the potential to affect cholesterol metabolism by affecting GSH/GSSG ratio, GSH-Px, and the HMGCR.	Cholesterol	95-106	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	163-168	
8994382-4	1996	Simvastatin, a potent inhibitor of the key enzyme controlling de novo cholesterol synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, completely inhibited (P < 0.05) progesterone production by granulosa cells and progesterone and androstenedione production by thecal cells.	Cholesterol	70-81	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	93-150	
220014-7	1979	The resultant free cholesterol was used for steroid synthesis and also acted to suppress the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol synthesis within the cell.	Cholesterol	19-30	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	105-152	
3665558-6	1987	We conclude that the activity of HMG CoA reductase is a major determinant of the rate of cholesterol synthesis in the lens.	Cholesterol	89-100	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	33-50	
2842664-1	1987	In order to investigate the pattern of ovarian cholesterol biosynthesis during the bovine estrous cycle, tissue concentrations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, a rate-limiting enzyme in the synthesis of cholesterol, were determined by immunoblot techniques.	Cholesterol	232-243	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	130-187	
30795041-10	1978	It is not known whether HMG occurs in cow"s milk, but HMG is known to inhibit the rate limiting enzyme in cholesterol biosynthesis, HMG-CoA-reductase.	Cholesterol	106-117	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	132-149	
26122311-2	2016	3-Hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis.	Cholesterol	74-85	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	0-40	
32645610-6	2020	Interestingly, down-regulation of miR-1, -128 and -27a also correlated with increased mRNA genes such as Hmgcs and Hmgcr encoding cholesterol synthesis in the mammary glands in response to lower circulating cholesterol levels.	Cholesterol	130-141	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	115-120	
32645610-6	2020	Interestingly, down-regulation of miR-1, -128 and -27a also correlated with increased mRNA genes such as Hmgcs and Hmgcr encoding cholesterol synthesis in the mammary glands in response to lower circulating cholesterol levels.	Cholesterol	207-218	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	115-120	
29590145-10	2018	Together with steroidogenic genes, most of the genes regulating de-novo cholesterol biosynthetic pathway (e.g HMGCS, HMGCR) and cholesterol uptake from plasma (LDLR, APOD and APOE) were upregulated in the mature CL.	Cholesterol	72-83	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	117-122	
26122311-2	2016	3-Hydroxy-3-methylglutaryl-CoA reductase (HMGR) is an essential enzyme in cholesterol biosynthesis.	Cholesterol	74-85	3-hydroxy-3-methylglutaryl-CoA reductase	Bos taurus	42-46