PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21715619-4	2011	In addition, brain cholesterol, its precursors, and the rate-limiting enzymes for cholesterol synthesis, HMG CoA synthase (HMGCS1) and HMG CoA reductase (HMGCR), were also reduced in PGC1alpha KO mice.	Cholesterol	19-30	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	123-129	
22977169-8	2013	The decrease in serum CHOL was consistent with the induction of hepatic reverse CHOL transport genes Lcat (2.0-fold), Apoa1 (1.7-fold), and Ldlr (3.6-fold), and the repression of CHOL biosynthesis genes Hmgcs1 (-2.1-fold) and Hmgcr (-2.3-fold).	Cholesterol	22-26	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	203-209	
21715619-4	2011	In addition, brain cholesterol, its precursors, and the rate-limiting enzymes for cholesterol synthesis, HMG CoA synthase (HMGCS1) and HMG CoA reductase (HMGCR), were also reduced in PGC1alpha KO mice.	Cholesterol	82-93	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	123-129	
19960455-7	2010	Hereby, we identified Q(10)H(2)-sensitive genes which are regulated by peroxisome proliferator-activated receptor-alpha and are primarily involved in cholesterol synthesis (e.g. HMGCS1, HMGCL and HMGCR), fat assimilation (FABP5), lipoprotein metabolism (PLTP) and inflammation (STAT-1).	Cholesterol	150-161	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	178-184	
33577922-13	2021	Global transcriptome profiles from stages of incipient motor deficit versus preterminal age identified molecules with progressive downregulation, where a cluster of cholesterol biosynthesis enzymes including Dhcr24, Msmo1, Idi1 and Hmgcs1 was prominent.	Cholesterol	165-176	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	232-238	
8097863-0	1993	Inhibition of hepatic cholesterol biosynthesis by a 3-hydroxy-3-methylglutaryl coenzyme A synthase inhibitor, 1233A, in mice.	Cholesterol	22-33	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	52-98	
34611127-6	2021	Mechanically, RNA-seq revealed that the expression of cholesterol-synthesis pathway genes such as HMGCS1 were decreased in YAP-/- astrocytes.	Cholesterol	54-65	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	98-104	
34611127-8	2021	Interestingly, upregulation of cholesterol-synthesis pathways by diarylpropionitrile (DPN) (an ERbeta-ligand, to upregulate the expression of HMGCS1) treatment partially rescued the demyelination deficits in YAPGFAP-CKO EAE mice.	Cholesterol	31-42	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	142-148	
34611127-10	2021	These findings identify unrecognized functions of astrocytic YAP in the prevention of demyelination through promoting cholesterol synthesis in EAE, and reveal a novel pathway of YAP/HMGCS1 for cholesterol synthesis in EAE pathology.	Cholesterol	193-204	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	182-188	
33549720-4	2021	Notably, PAR1 differentially regulated HMGCS1, a gene encoding a rate-limiting enzyme in cholesterol production, across the neuronal and astroglial compartments of the intact versus injured spinal cord.	Cholesterol	89-100	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	39-45	
33220403-10	2021	Expression of genes in cholesterol synthesis, transport or turnover (Abcg5, Abcg8, Abcc2, Cyp46a1, Hmgcs1) was perturbed by high folic acid intake.	Cholesterol	23-34	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	99-105	
28155669-7	2016	The top-most enriched mRNA, whose association with peroxisomes we confirm microscopically was Hmgcs1, encoding 3-hydroxy-3-methylglutaryl-CoA synthase, a crucial enzyme of cholesterol biosynthesis pathway.	Cholesterol	172-183	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	94-100	
30995083-7	2019	Expression of cholesterol-related HMGCS1, MVD, Cyp51a1, and DHCR was validated by quantitative reverse-transcription-polymerase chain reaction.	Cholesterol	14-25	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	34-40	
26838045-5	2016	The 2,4-D decreased cholesterol levels in Leydig cells of wild-type mice through down-regulating the expression of 3-hydroxy-3-methylglutaryl coenzyme A synthase 1 and reductase, involved in de novo cholesterogenesis.	Cholesterol	20-31	3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1	Mus musculus	115-177