PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18450749-5 2008 Suppression of OSBP in Chinese hamster ovary cells by RNA interference resulted in increased ABCA1 protein expression and cholesterol efflux activity following induction with oxysterols or the synthetic LXR agonist TO901317. Cholesterol 122-133 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 15-19 26601944-1 2016 Oxysterol-binding protein (OSBP) exchanges cholesterol and phosphatidylinositol 4-phosphate (PI-4P) at contact sites between the endoplasmic reticulum (ER) and the trans-Golgi/trans-Golgi network. Cholesterol 43-54 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 0-25 26601944-1 2016 Oxysterol-binding protein (OSBP) exchanges cholesterol and phosphatidylinositol 4-phosphate (PI-4P) at contact sites between the endoplasmic reticulum (ER) and the trans-Golgi/trans-Golgi network. Cholesterol 43-54 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 27-31 22875984-4 2012 A phosphomimetic of the SM/cholesterol-sensitive phosphorylation site 1 (OSBP-S5E) had increased in vitro cholesterol and 25-hydroxycholesterol-binding capacity, and cholesterol extraction from liposomes, but reduced transfer activity. Cholesterol 27-38 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 73-77 22875984-4 2012 A phosphomimetic of the SM/cholesterol-sensitive phosphorylation site 1 (OSBP-S5E) had increased in vitro cholesterol and 25-hydroxycholesterol-binding capacity, and cholesterol extraction from liposomes, but reduced transfer activity. Cholesterol 106-117 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 73-77 22875984-4 2012 A phosphomimetic of the SM/cholesterol-sensitive phosphorylation site 1 (OSBP-S5E) had increased in vitro cholesterol and 25-hydroxycholesterol-binding capacity, and cholesterol extraction from liposomes, but reduced transfer activity. Cholesterol 106-117 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 73-77 22875984-5 2012 Phosphatidylinositol 4-phosphate (PI(4)P) and cholesterol competed for a common binding site on OSBP; however, direct binding of PI(4)P was not affected by site 1 phosphorylation. Cholesterol 46-57 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 96-100 20881054-5 2010 Consistent with this sterol-requirement, OSBP silencing also reduced the cholesterol content of endosome/trans-Golgi network (TGN) fractions containing PI4KIIalpha. Cholesterol 73-84 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 41-45 9813079-0 1998 Differential effects of sphingomyelin hydrolysis and cholesterol transport on oxysterol-binding protein phosphorylation and Golgi localization. Cholesterol 53-64 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 78-103 16571669-2 2006 One mechanism for regulation of this metabolic interface involves oxysterol binding protein (OSBP) via high-affinity binding to oxysterol regulators of cholesterol homeostasis and activation of SM synthesis at the Golgi apparatus. Cholesterol 152-163 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 66-91 16571669-2 2006 One mechanism for regulation of this metabolic interface involves oxysterol binding protein (OSBP) via high-affinity binding to oxysterol regulators of cholesterol homeostasis and activation of SM synthesis at the Golgi apparatus. Cholesterol 152-163 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 93-97 16571669-4 2006 RNA interference (RNAi) experiments in Chinese hamster ovary (CHO)-K1 cells revealed that OSBP and vesicle-associated membrane protein-associated protein (VAP) were required for stimulation of CERT-dependent ceramide transport and SM synthesis by 25-hydroxycholesterol and cholesterol depletion in response to cyclodextrin. Cholesterol 257-268 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 90-94 11861666-0 2002 ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism. Cholesterol 65-76 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 19-44 11441133-1 2001 Oxysterol binding protein (OSBP) translocation between Golgi and vesicular/cytoplasmic compartments is affected by conditions that alter cholesterol and sphingomyelin homeostasis, indicating a role in lipid and sterol regulation in this organelle. Cholesterol 137-148 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 0-25 11441133-1 2001 Oxysterol binding protein (OSBP) translocation between Golgi and vesicular/cytoplasmic compartments is affected by conditions that alter cholesterol and sphingomyelin homeostasis, indicating a role in lipid and sterol regulation in this organelle. Cholesterol 137-148 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 27-31 11441133-2 2001 In this study, we show that OSBP dissociation from the Golgi apparatus was inhibited when LDL cholesterol efflux from lysosomes was blocked in Niemann-Pick C (NPC) or U18666A [3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one]-treated fibroblasts. Cholesterol 94-105 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 28-32 11441133-5 2001 However, OSBP in the Golgi apparatus was progressively dephosphorylated (as assessed by a molecular mass shift on SDS-PAGE) in U18666A-treated fibroblasts or Chinese hamster ovary cells as a result of combined inhibition of LDL cholesterol transport and de novo cholesterol synthesis. Cholesterol 228-239 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 9-13 11441133-5 2001 However, OSBP in the Golgi apparatus was progressively dephosphorylated (as assessed by a molecular mass shift on SDS-PAGE) in U18666A-treated fibroblasts or Chinese hamster ovary cells as a result of combined inhibition of LDL cholesterol transport and de novo cholesterol synthesis. Cholesterol 262-273 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 9-13 11441133-6 2001 In vivo phosphopeptide mapping and mutagenesis of OSBP was used to identify the cholesterol-sensitive phosphorylation sites at serines 381, 384, and 387 that were responsible for the altered mobility on SDS-PAGE. Cholesterol 80-91 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 50-54 11441133-7 2001 NPC-1 protein-mediated release of LDL-derived cholesterol and de novo biosynthesis regulates OSBP localization and phosphorylation. Cholesterol 46-57 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 93-97 9813079-7 1998 Cyclodextrin and U18666A also caused OSBP translocation to the Golgi apparatus, suggesting that OSBP movement is coupled to changes in the cholesterol content of the plasma membrane or Golgi apparatus. Cholesterol 139-150 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 96-100 9813079-8 1998 These results identify OSBP as a potential target of SM turnover and cholesterol mobilization at the plasma membrane and/or Golgi apparatus. Cholesterol 69-80 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 23-27 9337870-4 1997 CHO-OSBP cells showed a 40-60% decrease in acyl-CoA:cholesterol acyltransferase activity and mRNA, a 50% elevation in mRNA for three sterol-regulated genes [LDL receptor, 3-hydroxy-3-methylgluraryl (HMG)-CoA reductase and HMG-CoA synthase], and an 80% increase in [14C]acetate incorporation into cholesterol. Cholesterol 52-63 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 0-8 9806908-0 1998 Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol. Cholesterol 0-11 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 22-47 9806908-0 1998 Cholesterol regulates oxysterol binding protein (OSBP) phosphorylation and Golgi localization in Chinese hamster ovary cells: correlation with stimulation of sphingomyelin synthesis by 25-hydroxycholesterol. Cholesterol 0-11 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 49-53 9806908-2 1998 The potential role of oxysterols and oxysterol binding protein (OSBP) in mediating the coregulation of cholesterol and SM was examined using Chinese hamster ovary (CHO) and cholesterol auxotrophic, sterol regulatory defective (SRD) 6 cells. Cholesterol 103-114 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 37-62 9806908-2 1998 The potential role of oxysterols and oxysterol binding protein (OSBP) in mediating the coregulation of cholesterol and SM was examined using Chinese hamster ovary (CHO) and cholesterol auxotrophic, sterol regulatory defective (SRD) 6 cells. Cholesterol 103-114 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 64-68 9806908-2 1998 The potential role of oxysterols and oxysterol binding protein (OSBP) in mediating the coregulation of cholesterol and SM was examined using Chinese hamster ovary (CHO) and cholesterol auxotrophic, sterol regulatory defective (SRD) 6 cells. Cholesterol 173-184 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 64-68 9806908-8 1998 Unlike CHO 7 cells, where OSBP was observed in small vesicles and the cytoplasm, OSBP in cholesterol-starved SRD 6 cells was constitutively localized in the Golgi apparatus. Cholesterol 89-100 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 81-85 9806908-11 1998 Low-density lipoprotein (LDL) supplementation of CHO-K1 cells caused the redistribution of OSBP to the cytoplasm and small vesicles, and this effect was blocked by pharmacological agents ?3-beta-[2-(diethylamino)ethoxy]androst-5-en-17-one and progesterone?, which inhibited LDL cholesterol efflux from lysosomes. Cholesterol 278-289 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 91-95 9806908-12 1998 The results showed that localization of OSBP between the Golgi apparatus and a cytoplasmic/vesicular compartment was responsive to changes in cholesterol content and trafficking. Cholesterol 142-153 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 40-44 9806908-13 1998 In cholesterol depleted SRD 6 cells, this was accompanied by dephosphorylation of OSBP and attenuation of 25-hydroxycholesterol activation of SM synthesis. Cholesterol 3-14 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 82-86 9337870-0 1997 Altered regulation of cholesterol and cholesteryl ester synthesis in Chinese-hamster ovary cells overexpressing the oxysterol-binding protein is dependent on the pleckstrin homology domain. Cholesterol 22-33 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 116-141 9337870-1 1997 Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification. Cholesterol 108-119 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 0-25 9337870-1 1997 Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification. Cholesterol 108-119 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 27-31 9337870-1 1997 Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification. Cholesterol 140-151 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 0-25 9337870-1 1997 Oxysterol-binding protein (OSBP) is a high-affinity receptor for a variety of oxysterols, such as 25-hydroxycholesterol, that down-regulate cholesterol synthesis and stimulate cholesterol esterification. Cholesterol 140-151 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 27-31 9337870-2 1997 To examine a potential role for OSBP in regulating cholesterol metabolism, we stably overexpressed this protein in Chinese-hamster ovary (CHO)-K1 cells. Cholesterol 51-62 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 32-36 9337870-5 1997 CHO-K1 cells overexpressing two OSBP mutants with a complete or N-terminal deletion of the pleckstrin homology (PH) domain had cholesterol esterification and synthesis rates that were similar to those shown by mock-transfected controls. Cholesterol 127-138 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 32-36 9337870-7 1997 CHO-K1 cells overexpressing OSBP have pronounced alterations in cholesterol esterification and synthesis, indicating a potential role for this receptor in cholesterol homoeostasis. Cholesterol 64-75 LOW QUALITY PROTEIN: oxysterol-binding protein 1 Cricetulus griseus 28-32