PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7605373-1	1995	3-Hydroxy-3-methylglutaryl-CoA (HMG CoA) reductase inhibitors are the drugs most commonly prescribed in the US to lower blood cholesterol.	Cholesterol	126-137	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	0-50	
9763219-6	1998	Using RNase protection and radioimmunoprecipitation assays, we found that, in the absence of LDL in the culture medium, both HMGR mRNA levels and synthesis were reduced with concentrations of Ro 48-8071 inhibiting cholesterol synthesis by 50-75%, whereas LDL uptake was either reduced or unchanged.	Cholesterol	214-225	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	125-129	
9763219-7	1998	In contrast, simvastatin, at concentrations inhibiting cholesterol synthesis by the same 50-75%, increased both HMGR mRNA levels and synthesis, as well as LDL uptake.	Cholesterol	55-66	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	112-116	
10405006-9	1999	The activities of hepatic HMGCoA reductase, the rate-limiting enzyme for cholesterol synthesis, increased (+125%, p=0.06); hepatic cholesterol 7alpha-hydroxylase, the rate-limiting enzyme for bile acid synthesis, decreased (-85%); and the hepatic LDL receptor mass also decreased (-44%).	Cholesterol	73-84	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	26-42	
8301233-14	1993	It is possible that increases in hepatic HMG-CoA reductase provide cholesterol that allows for the increased production of lipoproteins and elevations in serum lipid levels that may be beneficial to the body"s host defense.	Cholesterol	67-78	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	41-58	
25701719-4	2015	In animals that are sensitive to dietary cholesterol such as Golden Syrian hamsters, feedback regulation occurs mainly at the level of transcription of hepatic HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase).	Cholesterol	41-52	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	160-177	
25701719-4	2015	In animals that are sensitive to dietary cholesterol such as Golden Syrian hamsters, feedback regulation occurs mainly at the level of transcription of hepatic HMG-CoA reductase (3-hydroxy-3-methylglutaryl coenzyme A reductase).	Cholesterol	41-52	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Mesocricetus auratus	179-226