PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16357153-3	2005	We have shown that COX-2 inhibition sensitizes human colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inducing clustering of the TRAIL receptor DR5 at the cell surface and the redistribution of the death-inducing signaling complex components (DR5, FADD, and procaspase-8) into cholesterol-rich and ceramide-rich domains known as caveolae.	Cholesterol	338-349	TNF receptor superfamily member 10b	Homo sapiens	205-208	
30765502-8	2019	Furthermore, intracellular cholesterol regulates temozolomide-induced cell death in glioblastoma cells via accumulation and activation of death receptor 5 in plasma membrane lipid rafts.	Cholesterol	27-38	TNF receptor superfamily member 10b	Homo sapiens	138-154	
29162448-0	2018	Intracellular cholesterol level regulates sensitivity of glioblastoma cells against temozolomide-induced cell death by modulation of caspase-8 activation via death receptor 5-accumulation and activation in the plasma membrane lipid raft.	Cholesterol	14-25	TNF receptor superfamily member 10b	Homo sapiens	158-174	
29957841-7	2018	The cholesterol-sequestering agent nystatin partially reversed DR5 clustering and DISC formation, preventing apoptosis triggered by the combination of beta-elemene and TRAIL.	Cholesterol	4-15	TNF receptor superfamily member 10b	Homo sapiens	63-66	
29162448-10	2018	These findings suggest that intracellular cholesterol level affects TMZ treatment of GBM mediated via a DR5-caspase-8 mechanism.	Cholesterol	42-53	TNF receptor superfamily member 10b	Homo sapiens	104-107	
29162448-7	2018	TMZ without or with MbetaCD and/or Chol caused accumulation of DR5 into the plasma membrane lipid raft and formed a complex with caspase-8, an extrinsic caspase cascade inducer, reflected in the induction of cell death.	Cholesterol	35-39	TNF receptor superfamily member 10b	Homo sapiens	63-66	
29162448-8	2018	In addition, treatment with caspase-8 inhibitor or knockdown of DR5 dramatically suppressed U251-Con cell death induced by combination treatment with TMZ, MbetaCD, and Chol.	Cholesterol	168-172	TNF receptor superfamily member 10b	Homo sapiens	64-67	
24710190-6	2014	The cholesterol-sequestering agent methyl-beta-cyclodextrin reversed the DR4 and DR5 clustering and reduced bufalin+TRAIL-induced apoptosis.	Cholesterol	4-15	TNF receptor superfamily member 10b	Homo sapiens	81-84	
27720987-0	2016	Death Receptor 5 Networks Require Membrane Cholesterol for Proper Structure and Function.	Cholesterol	43-54	TNF receptor superfamily member 10b	Homo sapiens	0-16	
27720987-1	2016	Death receptor 5 (DR5) is an apoptosis-inducing member of the tumor necrosis factor receptor superfamily, whose activity has been linked to membrane cholesterol content.	Cholesterol	149-160	TNF receptor superfamily member 10b	Homo sapiens	0-16	
27720987-1	2016	Death receptor 5 (DR5) is an apoptosis-inducing member of the tumor necrosis factor receptor superfamily, whose activity has been linked to membrane cholesterol content.	Cholesterol	149-160	TNF receptor superfamily member 10b	Homo sapiens	18-21	
27720987-2	2016	Upon ligand binding, DR5 forms large clusters within the plasma membrane that have often been assumed to be manifestations of receptor co-localization in cholesterol-rich membrane domains.	Cholesterol	154-165	TNF receptor superfamily member 10b	Homo sapiens	21-24	
27720987-11	2016	As evidence, we show that cholesterol is necessary for the covalent dimerization of DR5 transmembrane domains.	Cholesterol	26-37	TNF receptor superfamily member 10b	Homo sapiens	84-87	
21769428-7	2011	It suggested that the TRAIL-induced redistribution of DR4 and DR5 in lipid rafts contributed to the sensitivity to TRAIL in TRAIL-sensitive NSCLC H460 cell line, which was also confirmed by intervention tests of the cholesterol-sequestering agent nystatin.	Cholesterol	216-227	TNF receptor superfamily member 10b	Homo sapiens	62-65