PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22683860-1 2012 ORP8 is an oxysterol/cholesterol binding protein anchored to the endoplasmic reticulum and the nuclear envelope, and is abundantly expressed in the macrophage. Cholesterol 21-32 oxysterol binding protein-like 8 Mus musculus 0-4 25347070-2 2014 ORP8 downregulates ABCA1 expression in macrophages and cellular cholesterol efflux to apolipoprotein A-I. Cholesterol 64-75 oxysterol binding protein-like 8 Mus musculus 0-4 25347070-3 2014 In line, ORP8 knockout mice display increased amounts of HDL cholesterol in blood. Cholesterol 61-72 oxysterol binding protein-like 8 Mus musculus 9-13 25347070-7 2014 After 9 weeks of Western-Type diet feeding, serum levels of VLDL cholesterol were increased by 50% in ORP8 KO BM recipients compared to the wild-type recipients. Cholesterol 65-76 oxysterol binding protein-like 8 Mus musculus 102-106 21698267-3 2011 Adenoviral overexpression of ORP8 in mouse liver induced a decrease of cholesterol, phospholipids, and triglycerides in serum (-34%, -26%, -37%, respectively) and liver tissue (-40%, -12%, -24%), coinciding with reduction of nuclear (n)SREBP-1 and -2 and mRNA levels of their target genes. Cholesterol 71-82 oxysterol binding protein-like 8 Mus musculus 29-33