PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28213520-0	2017	Cholesterol up-regulates neuronal G protein-gated inwardly rectifying potassium (GIRK) channel activity in the hippocampus.	Cholesterol	0-11	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	81-85	
28213520-4	2017	Yet, the effect of cholesterol on G protein-gated inwardly rectifying potassium (GIRK) channels expressed in the brain is unknown.	Cholesterol	19-30	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	81-85	
28213520-8	2017	We also demonstrate that cholesterol plays a critical role in modulating neuronal GIRK currents.	Cholesterol	25-36	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	82-86	
28213520-10	2017	In accordance, elevated currents upon cholesterol enrichment were also observed in Xenopus oocytes expressing GIRK2 channels, the primary GIRK subunit expressed in the brain.	Cholesterol	38-49	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	110-114	
28213520-13	2017	These findings establish that cholesterol plays a critical role in modulating GIRK activity in the brain.	Cholesterol	30-41	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	78-82	
28213520-14	2017	Because up-regulation of GIRK function can reduce neuronal activity, our findings may lead to novel approaches for prevention and therapy of cholesterol-driven neurodegenerative disease.	Cholesterol	141-152	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	25-29	
28377218-2	2017	Recently, we have shown that the activity of the heterotetrameric Kir3.1/Kir3.4 channel that underlies atrial KACh currents was enhanced by cholesterol.	Cholesterol	140-151	potassium inwardly rectifying channel subfamily J member 3 L homeolog	Xenopus laevis	66-72