PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20814015-4 2010 When 0.005% ezetimibe was added to the diet to block cholesterol absorption, Lpl expression in the liver was reduced significantly, and the plasma triglyceride levels were significantly higher (>170 mmol/L). Cholesterol 53-64 lipoprotein lipase Mus musculus 77-80 20814015-6 2010 The high-cholesterol diet significantly increased Lpl expression in the liver and lowered plasma triglyceride levels. Cholesterol 9-20 lipoprotein lipase Mus musculus 50-53 18367731-3 2008 Administration of an adenovirus expressing LPL (AdLPL) into lrp(-)ldlr(-/-)vldlr(-/-) mice reduced both VLDL-triglyceride (TG) and VLDL-total cholesterol (TC) levels. Cholesterol 142-153 lipoprotein lipase Mus musculus 43-46 17761937-0 2007 Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Cholesterol 20-31 lipoprotein lipase Mus musculus 69-72 17761937-0 2007 Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake. Cholesterol 99-110 lipoprotein lipase Mus musculus 69-72 17822335-1 2007 The activity of lipoprotein lipase (LPL) is increased after alcohol consumption and can contribute to an increased level of HDL-cholesterol, which is considered to play a key role in the ethanol-mediated protective effect against cardiovascular disease. Cholesterol 128-139 lipoprotein lipase Mus musculus 16-34 17189607-0 2007 Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle. Cholesterol 45-56 lipoprotein lipase Mus musculus 11-29 17189607-5 2007 Overexpression of a myocyte-anchored form of LPL in heart muscle led to increased uptake of LDL and greater heart cholesterol levels. Cholesterol 114-125 lipoprotein lipase Mus musculus 45-48 17189607-9 2007 Plasma creatinine phosphokinase as well as muscle mitochondria, cholesterol, and lipid droplet levels were increased in statin-treated mice overexpressing LPL in skeletal muscle. Cholesterol 64-75 lipoprotein lipase Mus musculus 155-158 17090659-10 2007 In the presence of LDLR, inactive LPL reduced LDL cholesterol significantly (13-24%). Cholesterol 50-61 lipoprotein lipase Mus musculus 34-37 17822335-1 2007 The activity of lipoprotein lipase (LPL) is increased after alcohol consumption and can contribute to an increased level of HDL-cholesterol, which is considered to play a key role in the ethanol-mediated protective effect against cardiovascular disease. Cholesterol 128-139 lipoprotein lipase Mus musculus 36-39 15456739-6 2004 Overexpression of LPL-EL in wild-type mice resulted in significantly reduced levels of HDL cholesterol and phospholipids by 93 and 85%, respectively, similar to the extent seen in EL-expressing mice, whereas no reduction of these parameters was observed in LPL-expressing mice. Cholesterol 91-102 lipoprotein lipase Mus musculus 18-21 16002740-1 2005 The naturally occurring human lipoprotein lipase S447X variant (LPLS447X) exemplifies a gain-of function mutation with significant benefits including decreased plasma triglycerides (TG), increased high-density lipoprotein (HDL) cholesterol, and reduced risk of coronary artery disease. Cholesterol 228-239 lipoprotein lipase Mus musculus 30-48 16041409-8 2005 These studies suggest that arterial LDL-CE delivery via SU can be an important mechanism in vivo and that dietary influences on arterial LPL levels and atherogenesis modulate arterial LDL-CE delivery, cholesterol deposition, and SU. Cholesterol 201-212 lipoprotein lipase Mus musculus 137-140 15085072-8 2004 This would suggest that hypertriglyceridemia and hypercholesterolemia result from inhibition of LPL and C7alphaH, respectively, while the biologic activity of CETP and LCAT are indirectly increased to compensate for the increased cholesterol burden. Cholesterol 54-65 lipoprotein lipase Mus musculus 96-99 15056458-8 2004 These results suggest that LPL is involved in the recycling of cholesterol and lipids released from degenerating terminals after a lesion through a syndecan-4-dependent pathway. Cholesterol 63-74 lipoprotein lipase Mus musculus 27-30 11562371-2 2001 In liver, LPL is also believed to promote uptake of high density lipoprotein (HDL)-cholesterol and thereby facilitate reverse cholesterol transport. Cholesterol 83-94 lipoprotein lipase Mus musculus 10-13 11562371-2 2001 In liver, LPL is also believed to promote uptake of high density lipoprotein (HDL)-cholesterol and thereby facilitate reverse cholesterol transport. Cholesterol 126-137 lipoprotein lipase Mus musculus 10-13 11562371-4 2001 Mice fed diets containing high cholesterol or an LXR-selective agonist exhibited a significant increase in LPL expression in the liver and macrophages, but not in other tissues (e.g. adipose and muscle). Cholesterol 31-42 lipoprotein lipase Mus musculus 107-110 10856527-3 2000 When added together, LPL and Ca(2+) synergistically increased the binding and uptake of native and oxidized LDL, and the deposition of esterified cholesterol derived from native and mildly or moderately oxidized LDL, in MPM. Cholesterol 146-157 lipoprotein lipase Mus musculus 21-24 11090277-3 2000 Cholesterol depletion of culture medium resulted in a significant induction of LPL mRNA in the 3T3-L1 preadipocyte cell line, whereas addition of cholesterol reduced LPL mRNA expression to basal levels. Cholesterol 0-11 lipoprotein lipase Mus musculus 79-82 11090277-3 2000 Cholesterol depletion of culture medium resulted in a significant induction of LPL mRNA in the 3T3-L1 preadipocyte cell line, whereas addition of cholesterol reduced LPL mRNA expression to basal levels. Cholesterol 146-157 lipoprotein lipase Mus musculus 166-169 10978269-4 2000 Eight weeks after bone marrow transplantation (BMT), serum cholesterol levels in LPL-/--->C57BL/6 mice were reduced by 8% compared with those in LPL+/+-->C57BL/6 mice (P:<0.05, n=16), whereas triglycerides were increased by 33% (P:<0.05, n=16). Cholesterol 59-70 lipoprotein lipase Mus musculus 81-84 10978269-5 2000 Feeding the mice a high-cholesterol diet increased serum cholesterol levels in LPL-/--->C57BL/6 and LPL+/+-->C57BL/6 mice 5-fold and 9-fold, respectively, resulting in a difference of approximately 50% (P:<0. Cholesterol 24-35 lipoprotein lipase Mus musculus 79-82 10978269-5 2000 Feeding the mice a high-cholesterol diet increased serum cholesterol levels in LPL-/--->C57BL/6 and LPL+/+-->C57BL/6 mice 5-fold and 9-fold, respectively, resulting in a difference of approximately 50% (P:<0. Cholesterol 24-35 lipoprotein lipase Mus musculus 103-106 10978269-5 2000 Feeding the mice a high-cholesterol diet increased serum cholesterol levels in LPL-/--->C57BL/6 and LPL+/+-->C57BL/6 mice 5-fold and 9-fold, respectively, resulting in a difference of approximately 50% (P:<0. Cholesterol 57-68 lipoprotein lipase Mus musculus 79-82 10978269-9 2000 After 3 months on a high-cholesterol diet, the atherosclerotic lesion area in LPL-/--->C57BL/6 mice was reduced by 52% compared with controls. Cholesterol 25-36 lipoprotein lipase Mus musculus 78-81 10978269-10 2000 It can be concluded that macrophage-derived LPL plays a significant role in the regulation of serum cholesterol, apolipoprotein E, and atherogenesis, suggesting that specific blockade of macrophage LPL production may be beneficial for decreasing atherosclerotic lesion development. Cholesterol 100-111 lipoprotein lipase Mus musculus 44-47 9651338-14 1998 Thus, apoE2 lowers LDL cholesterol by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins (mostly by displacing or masking apoC-II). Cholesterol 23-34 lipoprotein lipase Mus musculus 48-66 10744772-5 2000 Reduced LPL in both plasma and vessel wall (LPL(+/-)E(-/-)) was associated with increased TG and increased total cholesterol (TC) compared with LPL(+/+)E(-/-) sibs. Cholesterol 113-124 lipoprotein lipase Mus musculus 8-11 10744772-5 2000 Reduced LPL in both plasma and vessel wall (LPL(+/-)E(-/-)) was associated with increased TG and increased total cholesterol (TC) compared with LPL(+/+)E(-/-) sibs. Cholesterol 113-124 lipoprotein lipase Mus musculus 44-47 10744772-5 2000 Reduced LPL in both plasma and vessel wall (LPL(+/-)E(-/-)) was associated with increased TG and increased total cholesterol (TC) compared with LPL(+/+)E(-/-) sibs. Cholesterol 113-124 lipoprotein lipase Mus musculus 44-47 10077655-11 1999 From this genetic model of LPL deficiency in SM and AT, it can be concluded that CM-specific LPL expression is a major determinant in the regulation of plasma TG and HDL-cholesterol levels. Cholesterol 170-181 lipoprotein lipase Mus musculus 27-30 9382958-5 1997 Overexpression of LPL resulted in marked reductions in total plasma cholesterol (TC; 48%, 43%, 25%) and triglycerides (TTg; 63%, 40%, 70%, p < 0.01) in apoE-/-, LDLr-/-, and wild-type (WT) mice, respectively. Cholesterol 68-79 lipoprotein lipase Mus musculus 18-21 9409224-1 1997 Humans homozygous or heterozygous for mutations in the lipoprotein lipase (LPL) gene demonstrate significant disturbances in plasma lipoproteins, including raised triglyceride (TG) and reduced HDL cholesterol levels. Cholesterol 197-208 lipoprotein lipase Mus musculus 55-73 9409224-1 1997 Humans homozygous or heterozygous for mutations in the lipoprotein lipase (LPL) gene demonstrate significant disturbances in plasma lipoproteins, including raised triglyceride (TG) and reduced HDL cholesterol levels. Cholesterol 197-208 lipoprotein lipase Mus musculus 75-78 33247991-1 2021 AIM: We recently reported that lipoprotein lipase (LPL)-mediated free cholesterol (FC) accumulation in hepatic stellate cells (HSCs) augmented liver fibrosis in nonalcoholic steatohepatitis (NASH). Cholesterol 70-81 lipoprotein lipase Mus musculus 51-54 8500514-7 1993 Basal mLPL was negatively correlated with serum triglycerides (r = -0.48, P < 0.05) and positively correlated with HDL-cholesterol (r = 0.58, P < 0.01). Cholesterol 122-133 lipoprotein lipase Mus musculus 6-10 9374130-1 1997 Plasma lipoprotein lipase (LPL) activity correlates with high density lipoprotein (HDL) cholesterol levels in humans. Cholesterol 88-99 lipoprotein lipase Mus musculus 7-25 9374130-6 1997 Furthermore, in the presence of CETP, a significant positive correlation between LPL activity and HDL cholesterol was evident (r = 0.15, P = 0.006), while in the absence of CETP no such correlation was detected (r = 0.15, P = 0.36), highlighting the interactions between LPL and CETP in vivo. Cholesterol 102-113 lipoprotein lipase Mus musculus 81-84 9374130-7 1997 When mice were challenged with a high fat, high carbohydrate diet, strong correlations between LPL activity and HDL cholesterol were seen in both the presence (r = 0.45, P = 0.03) and absence (r = 0.73, P < 0.001) of CETP. Cholesterol 116-127 lipoprotein lipase Mus musculus 95-98 9374130-8 1997 Therefore, under altered metabolic contexts, such as those induced by dietary challenge, the relation between LPL activity and HDL cholesterol may also become evident. Cholesterol 131-142 lipoprotein lipase Mus musculus 110-113 9374130-9 1997 Here we have shown that both genetic and environmental factors may modulate the association between LPL activity and HDL cholesterol, and provide explanations for the absence of any changes in HDL values in mice either transgenic or with targeted disruption of the LPL gene. Cholesterol 121-132 lipoprotein lipase Mus musculus 100-103 9374130-9 1997 Here we have shown that both genetic and environmental factors may modulate the association between LPL activity and HDL cholesterol, and provide explanations for the absence of any changes in HDL values in mice either transgenic or with targeted disruption of the LPL gene. Cholesterol 121-132 lipoprotein lipase Mus musculus 265-268 33247991-1 2021 AIM: We recently reported that lipoprotein lipase (LPL)-mediated free cholesterol (FC) accumulation in hepatic stellate cells (HSCs) augmented liver fibrosis in nonalcoholic steatohepatitis (NASH). Cholesterol 70-81 lipoprotein lipase Mus musculus 31-49 33748195-2 2021 Mechanistically, it has been shown that thermogenic activation increases lipoprotein lipase (LPL)-dependent hydrolysis of triglyceride-rich lipoproteins (TRL) and accelerates the generation of cholesterol-enriched remnants and high-density lipoprotein (HDL), which promotes cholesterol flux from the periphery to the liver. Cholesterol 274-285 lipoprotein lipase Mus musculus 93-96 33530703-1 2021 Rationale: Hypertriglyceridemia (HyperTG) and low high-density lipoprotein cholesterol (HDL-C), both of which are regulated by lipoprotein lipase (LpL) activity, associate with increased cardiovascular disease (CVD). Cholesterol 75-86 lipoprotein lipase Mus musculus 127-145 33748195-2 2021 Mechanistically, it has been shown that thermogenic activation increases lipoprotein lipase (LPL)-dependent hydrolysis of triglyceride-rich lipoproteins (TRL) and accelerates the generation of cholesterol-enriched remnants and high-density lipoprotein (HDL), which promotes cholesterol flux from the periphery to the liver. Cholesterol 193-204 lipoprotein lipase Mus musculus 93-96 33748195-2 2021 Mechanistically, it has been shown that thermogenic activation increases lipoprotein lipase (LPL)-dependent hydrolysis of triglyceride-rich lipoproteins (TRL) and accelerates the generation of cholesterol-enriched remnants and high-density lipoprotein (HDL), which promotes cholesterol flux from the periphery to the liver. Cholesterol 274-285 lipoprotein lipase Mus musculus 73-91 32907987-9 2020 Bioinformatics analysis identified ABCA7, ABCG5, Lipoprotein Lipase and Mitochondrial Translocator Protein as possible candidates that may mediate the cholesterol flux. Cholesterol 151-162 lipoprotein lipase Mus musculus 49-67 26851362-15 2017 We show here that treatment of wildtype mice with dietary cholesterol under the same conditions as in the above study induced the LXR target genes Lpl, Abcg8 and Srebp1c in wild type mice but failed to activate the same genes in mice lacking 27-hydroxycholesterol due to a knockout of Cyp27. Cholesterol 58-69 lipoprotein lipase Mus musculus 147-150 24747115-0 2014 Incremental replacement of saturated fats by n-3 fatty acids in high-fat, high-cholesterol diets reduces elevated plasma lipid levels and arterial lipoprotein lipase, macrophages and atherosclerosis in LDLR-/- mice. Cholesterol 79-90 lipoprotein lipase Mus musculus 147-165 23937379-7 2013 The results suggested that higher plasma total cholesterol content possibly due to lower fecal steroid excretion as well as lower VLDL-C and triglyceride contents might due to the up-regulated expression levels of the genes CYP51, LDLR, and LPL. Cholesterol 47-58 lipoprotein lipase Mus musculus 241-244 31388630-9 2019 Nonenzymatic LPL-mediated cholesterol uptake from serum lipoproteins enhanced the accumulation of free cholesterol in HSCs, which amplified TLR4 signaling, resulting in the activation of HSCs and progression of hepatic fibrosis in NASH. Cholesterol 26-37 lipoprotein lipase Mus musculus 13-16 31388630-9 2019 Nonenzymatic LPL-mediated cholesterol uptake from serum lipoproteins enhanced the accumulation of free cholesterol in HSCs, which amplified TLR4 signaling, resulting in the activation of HSCs and progression of hepatic fibrosis in NASH. Cholesterol 103-114 lipoprotein lipase Mus musculus 13-16