PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12032489-8	2002	Parallel to the increase in the cholesterol saturation index, the contractile responses to CCK-8 decreased in the animals fed a high-cholesterol diet for 4 weeks and markedly decreased in the animals with gallstone formation.	Cholesterol	32-43	cholecystokinin	Canis lupus familiaris	91-94	
12032489-8	2002	Parallel to the increase in the cholesterol saturation index, the contractile responses to CCK-8 decreased in the animals fed a high-cholesterol diet for 4 weeks and markedly decreased in the animals with gallstone formation.	Cholesterol	133-144	cholecystokinin	Canis lupus familiaris	91-94	
12032489-11	2002	Up-regulation of the CCK-A receptor mRNA in the gallbladder of animals fed a high-cholesterol diet associated with decreased contractility may be due to an impairment of CCK signaling related to increased membrane cholesterol contents and its related reaction of biological compensation in order to increase the receptor concentration.	Cholesterol	82-93	cholecystokinin	Canis lupus familiaris	21-24	
12032489-11	2002	Up-regulation of the CCK-A receptor mRNA in the gallbladder of animals fed a high-cholesterol diet associated with decreased contractility may be due to an impairment of CCK signaling related to increased membrane cholesterol contents and its related reaction of biological compensation in order to increase the receptor concentration.	Cholesterol	214-225	cholecystokinin	Canis lupus familiaris	21-24	
12032489-12	2002	The results of the present study suggest that in prairie dogs fed a high-cholesterol diet both a decrease in gallbladder contractility related to impairment of CCK signaling and phospholipase A(2) (PLA(2))-induced mucosal inflammation in the gallbladder with associated biliary alterations favoring cholesterol crystal formation pathogenetically contribute to the formation of cholesterol gallstones.	Cholesterol	73-84	cholecystokinin	Canis lupus familiaris	160-163	
9142916-5	1997	Gallbladder muscle cells from high-cholesterol-fed prairie dogs contracted less in response to CCK octapeptide (CCK-8) than those from the control group.	Cholesterol	35-46	cholecystokinin	Canis lupus familiaris	95-98