PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31519191-10	2019	Mechanistically, cholesterol induced activation of PKA/SUFU/GLI1 signaling via smoothened receptor, which was well-known as Hedgehog signaling, resulting in inhibiting apoptosis and promoting cell cycle.	Cholesterol	17-28	GLI family zinc finger 1	Homo sapiens	60-64	
30317648-9	2019	Interestingly, depletion of endogenous cholesterol also reduced Shh-induced ALP activity and Gli1 expression.	Cholesterol	39-50	GLI family zinc finger 1	Homo sapiens	93-97	
30317648-7	2019	We found that exogenous cholesterol significantly inhibited alkaline phosphatase (ALP) activity and messenger RNA expression of osteoblast markers genes (Alpl, Sp7, and Ibsp) while modestly activating expression of Gli1 (a readout of Hh signaling) under both basal osteogenic culture condition and Wnt3a treatment.	Cholesterol	24-35	GLI family zinc finger 1	Homo sapiens	215-219	
30317648-8	2019	Similarly, exogenous cholesterol suppressed osteogenic response of ST2 cells to sonic Hh (Shh) or purmorphamine (Purmo) treatment, which, however, was accompanied by diminished induction of Gli1, indicating the involvement of a Hh-dependent mechanism.	Cholesterol	21-32	GLI family zinc finger 1	Homo sapiens	190-194	
26315393-8	2016	A higher level of Gli-mediated transcription resulted in accumulation of intracellular cholesterol.	Cholesterol	87-98	GLI family zinc finger 1	Homo sapiens	18-21