PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30987969-6 2019 hmgcs1 encodes the first enzyme in the cholesterol synthesis pathway and mutation of hmgcs1 inhibits cholesterol synthesis. Cholesterol 39-50 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Danio rerio 0-6 30987969-6 2019 hmgcs1 encodes the first enzyme in the cholesterol synthesis pathway and mutation of hmgcs1 inhibits cholesterol synthesis. Cholesterol 101-112 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Danio rerio 0-6 30987969-6 2019 hmgcs1 encodes the first enzyme in the cholesterol synthesis pathway and mutation of hmgcs1 inhibits cholesterol synthesis. Cholesterol 101-112 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Danio rerio 85-91 28686747-0 2017 Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development. Cholesterol 90-101 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Danio rerio 49-55 28686747-7 2017 Our analysis confirmed that mutation of hmgcs1, which encodes the first enzyme in the cholesterol synthesis pathway, results in craniofacial abnormalities via defects in cranial neural crest cell differentiation. Cholesterol 86-97 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Danio rerio 40-46 24573296-4 2014 Through a forward genetic screen in zebrafish we discovered that mutation of hmgcs1, which encodes an enzyme necessary for isoprenoid and cholesterol synthesis, causes oligodendrocyte progenitor cells (OPCs) to migrate past their target axons and to fail to express myelin genes. Cholesterol 138-149 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Danio rerio 77-83