PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32760429-8 2020 Previous studies have proved that deleterious heterozygous ABCA8 variants may disrupt cholesterol efflux and reduce HDL-c levels in humans and mice. Cholesterol 86-97 ATP binding cassette subfamily A member 8 Homo sapiens 59-64 28882873-7 2017 HDLc levels were significantly decreased by 29% (P=0.01) in Abca8b-/- mice on a high-cholesterol diet compared with wild-type mice, whereas hepatic overexpression of human ABCA8 in mice resulted in significant increases in plasma HDLc and the first steps of macrophage-to-feces reverse cholesterol transport. Cholesterol 286-297 ATP binding cassette subfamily A member 8 Homo sapiens 172-177 28882873-10 2017 CONCLUSIONS: ABCA8 facilitates cholesterol efflux and modulates HDLc levels in humans and mice. Cholesterol 31-42 ATP binding cassette subfamily A member 8 Homo sapiens 13-18 32760429-9 2020 This study may be the second report related to ABCA8 mutations in patients with reduced levels of HDL-c. Our study not only contributed to the genetic counseling and prenatal genetic diagnosis of patients with ASCVD caused by reduced HDL-c levels, but also provided a new sight among ABCA8, cholesterol efflux and HDL-c levels. Cholesterol 291-302 ATP binding cassette subfamily A member 8 Homo sapiens 47-52 32430024-2 2020 ABCA8 is a transmembrane transporter responsible for the transport of organics, such as cholesterol, and drug efflux. Cholesterol 88-99 ATP binding cassette subfamily A member 8 Homo sapiens 0-5