PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16162271-6	2005	Cholesterol depletion prevented the association of hypercrosslinked CD20 with detergent-insoluble rafts, and attenuated both calcium mobilization and apoptosis induced with rituximab.	Cholesterol	0-11	keratin 20	Homo sapiens	68-72	
12835728-0	2003	A cholesterol-dependent CD20 epitope detected by the FMC7 antibody.	Cholesterol	2-13	keratin 20	Homo sapiens	24-28	
15730389-8	2005	Furthermore, we demonstrate that disturbing the raft integrity by cholesterol extraction results in dissociation of CD20 from a Triton X-100 resistant fraction followed by complete inhibition of Rituxan-induced calcium entry and apoptosis.	Cholesterol	66-77	keratin 20	Homo sapiens	116-120	
12835728-8	2003	Of significant interest, the CD20 epitope recognized by FMC7 was unusual in that it was exceptionally sensitive to membrane cholesterol.	Cholesterol	124-135	keratin 20	Homo sapiens	29-33	
12835728-10	2003	FMC7 mAb binding thus appears to be a sensitive indicator of the level of plasma membrane cholesterol and reveals a conformational state of CD20 that is regulated by cholesterol.	Cholesterol	166-177	keratin 20	Homo sapiens	140-144	
23603515-0	2013	Rituximab activates Syk and AKT in CD20-positive B cell lymphoma cells dependent on cell membrane cholesterol levels.	Cholesterol	98-109	keratin 20	Homo sapiens	35-39	
12218101-1	2002	The B cell Ag receptor (BCR) and CD20, a putative calcium channel, inducibly associate with cholesterol-dependent membrane microdomains known as lipid rafts.	Cholesterol	92-103	keratin 20	Homo sapiens	33-37	
25541029-2	2015	However, activity of rituximab may be reduced by conformational change in CD20 by statin-induced cholesterol depletion.	Cholesterol	97-108	keratin 20	Homo sapiens	74-78	
17336267-4	2007	Cholesterol depletion promoted a decrease in the number of sites accessed by CD20, CXCR4 and Gb(3)/CD77 antibodies.	Cholesterol	0-11	keratin 20	Homo sapiens	77-81	
18366248-9	2008	Atomic force microscopy and limited proteolysis indicated that statins, through cholesterol depletion, induce conformational changes in CD20 that result in impaired binding of anti-CD20 mAb.	Cholesterol	80-91	keratin 20	Homo sapiens	136-140	
18366248-9	2008	Atomic force microscopy and limited proteolysis indicated that statins, through cholesterol depletion, induce conformational changes in CD20 that result in impaired binding of anti-CD20 mAb.	Cholesterol	80-91	keratin 20	Homo sapiens	181-185	
18366248-10	2008	An in vivo reduction of cholesterol induced by short-term treatment of five patients with hypercholesterolemia with atorvastatin resulted in reduced anti-CD20 binding to freshly isolated B cells.	Cholesterol	24-35	keratin 20	Homo sapiens	154-158	
17336267-7	2007	Thus, the binding of Gb(3)/CD77 by its cognate ligand transmits information within the lipid bilayer of model lymphoma cells to impact the behaviour of selective proteins, most notably CD20, via a mechanism influenced by the level of cholesterol within the membrane.	Cholesterol	234-245	keratin 20	Homo sapiens	185-189