PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15995177-5 2005 The reduction in hepatic cholesterol was associated with a low expression of liver X receptor-alpha and its target genes, 7-alpha hydroxylase and ABCA1. Cholesterol 25-36 ATP binding cassette subfamily A member 1 Rattus norvegicus 146-151 15358158-1 2004 ATP binding cassette A1 (ABCA1) is responsible in vivo for the formation of HDL by promoting the lipidation of apoprotein A-I (apoA-I) via cholesterol and phospholipid efflux from the liver. Cholesterol 139-150 ATP binding cassette subfamily A member 1 Rattus norvegicus 0-23 15358158-1 2004 ATP binding cassette A1 (ABCA1) is responsible in vivo for the formation of HDL by promoting the lipidation of apoprotein A-I (apoA-I) via cholesterol and phospholipid efflux from the liver. Cholesterol 139-150 ATP binding cassette subfamily A member 1 Rattus norvegicus 25-30 15358158-4 2004 In both basal and ABCA1 expressing cells pitavastatin 0.1-50microM induced a dose-dependent increase in cholesterol efflux to apoA-I; this effect was reversed by mevalonate or geranyl geraniol. Cholesterol 104-115 ATP binding cassette subfamily A member 1 Rattus norvegicus 18-23 14690017-11 2003 Clofibrate increases cytochrome P450 content and the resulting oxysterol generation may partly mediate the clofibrate-induced up-regulattion of LXRa and ABCA1, which are related to reverse cholesterol transport. Cholesterol 189-200 ATP binding cassette subfamily A member 1 Rattus norvegicus 153-158 12909583-5 2003 Stimulation of ABCA1 in rat type II cells by 9cRA + 22-OH resulted in a four- or fivefold enhancement of efflux of radioactive phospholipid or cholesterol, respectively, from the pneumocytes to apolipoprotein AI (apo AI), whereas cAMP (0.3 mM) had no effect. Cholesterol 143-154 ATP binding cassette subfamily A member 1 Rattus norvegicus 15-20 12547833-0 2003 22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion. Cholesterol 11-22 ATP binding cassette subfamily A member 1 Rattus norvegicus 54-89 12547833-1 2003 The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of peripheral cholesterol efflux and plasma high density lipoprotein metabolism. Cholesterol 83-94 ATP binding cassette subfamily A member 1 Rattus norvegicus 4-39 12547833-1 2003 The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of peripheral cholesterol efflux and plasma high density lipoprotein metabolism. Cholesterol 83-94 ATP binding cassette subfamily A member 1 Rattus norvegicus 41-46 12547833-7 2003 Functionally, the increased ABCA1 expression caused by these ligands was followed by elevated apoA-I- and apoE-specific cholesterol efflux in neurons and glia. Cholesterol 120-131 ATP binding cassette subfamily A member 1 Rattus norvegicus 28-33 12576511-5 2003 ApoA-I-dependent cholesterol efflux was increased 2.6-fold in primary hepatocytes isolated 1 day after rABCA1-GFP-AdV infusion. Cholesterol 17-28 ATP binding cassette subfamily A member 1 Rattus norvegicus 103-109 12507911-10 2003 Cholesterol increments were associated with decreased SR-B1, increased ABCA1, and increased HMG CoA reductase (HMGCR) protein and its mRNA. Cholesterol 0-11 ATP binding cassette subfamily A member 1 Rattus norvegicus 71-76 12507911-11 2003 Tubule (HK-2) cell culture data indicated that SR-B1 and ABCA1 levels are responsive to cholesterol supply. Cholesterol 88-99 ATP binding cassette subfamily A member 1 Rattus norvegicus 57-62 12507911-13 2003 These changes are associated with adaptations in SR-B1 and ABCA1 expression, which are physiologically appropriate changes for a cholesterol overload state. Cholesterol 129-140 ATP binding cassette subfamily A member 1 Rattus norvegicus 59-64 12384498-1 2002 The expression, function, and regulation of the cholesterol efflux molecule, ABCA1, has been extensively examined in peripheral tissues but only poorly studied in the brain. Cholesterol 48-59 ATP binding cassette subfamily A member 1 Rattus norvegicus 77-82 12384498-12 2002 These data suggest that the cholesterol efflux molecule ABCA1 may also be involved in the secretion of the membrane-associated molecule, Abeta. Cholesterol 28-39 ATP binding cassette subfamily A member 1 Rattus norvegicus 56-61 12072387-4 2002 LXR activation also induces the expression of the lipid pump involved in cholesterol efflux, the gene encoding ATP binding cassette protein A1 (ABCA1). Cholesterol 73-84 ATP binding cassette subfamily A member 1 Rattus norvegicus 111-142 12072387-4 2002 LXR activation also induces the expression of the lipid pump involved in cholesterol efflux, the gene encoding ATP binding cassette protein A1 (ABCA1). Cholesterol 73-84 ATP binding cassette subfamily A member 1 Rattus norvegicus 144-149 34578896-6 2021 Consistently, OxLDL suppressed cholesterol transporter ABCA1 expression and transcription in a dose-dependent and time-dependent manner. Cholesterol 31-42 ATP binding cassette subfamily A member 1 Rattus norvegicus 55-60 34578896-11 2021 In summary, our study shows that OxLDL down-regulates ABCA1 expression by MEK/ERK/LXR pathway, leading to cholesterol accumulation in INS-1 cells, which may result in impaired insulin synthesis and GSIS. Cholesterol 106-117 ATP binding cassette subfamily A member 1 Rattus norvegicus 54-59 34307343-0 2021 GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic beta-Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux. Cholesterol 130-141 ATP binding cassette subfamily A member 1 Rattus norvegicus 72-77 34307343-0 2021 GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic beta-Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux. Cholesterol 167-178 ATP binding cassette subfamily A member 1 Rattus norvegicus 72-77 34307343-5 2021 Enhanced cell apoptosis and inhibited cholesterol efflux from INS-1 cells; meanwhile, ABCA1 protein level was decreased by cholesterol stimulation. Cholesterol 38-49 ATP binding cassette subfamily A member 1 Rattus norvegicus 86-91 34307343-5 2021 Enhanced cell apoptosis and inhibited cholesterol efflux from INS-1 cells; meanwhile, ABCA1 protein level was decreased by cholesterol stimulation. Cholesterol 123-134 ATP binding cassette subfamily A member 1 Rattus norvegicus 86-91 35085709-0 2022 A high-fat/high-cholesterol diet, but not high-cholesterol alone, increases free cholesterol and apoE-rich HDL serum levels in rats and upregulates hepatic ABCA1 expression. Cholesterol 16-27 ATP binding cassette subfamily A member 1 Rattus norvegicus 156-161 35085709-9 2022 These results suggest that an increase in apoE-rich HDL induced by dietary fat and cholesterol may be involved in cholesterol efflux from the liver through increased ABCA1-mediated free-cholesterol efflux. Cholesterol 83-94 ATP binding cassette subfamily A member 1 Rattus norvegicus 166-171 35085709-9 2022 These results suggest that an increase in apoE-rich HDL induced by dietary fat and cholesterol may be involved in cholesterol efflux from the liver through increased ABCA1-mediated free-cholesterol efflux. Cholesterol 114-125 ATP binding cassette subfamily A member 1 Rattus norvegicus 166-171 35085709-9 2022 These results suggest that an increase in apoE-rich HDL induced by dietary fat and cholesterol may be involved in cholesterol efflux from the liver through increased ABCA1-mediated free-cholesterol efflux. Cholesterol 186-197 ATP binding cassette subfamily A member 1 Rattus norvegicus 166-171 32982759-2 2020 FaDOH has been shown to activate PPARgamma and to increase the expression of the cholesterol transporter ABCA1 in cells, both of which play an important role in lipid metabolism. Cholesterol 81-92 ATP binding cassette subfamily A member 1 Rattus norvegicus 105-110 31857643-0 2019 Identification of a novel cholesterol-lowering dipeptide, phenylalanine-proline (FP), and its down-regulation of intestinal ABCA1 in hypercholesterolemic rats and Caco-2 cells. Cholesterol 26-37 ATP binding cassette subfamily A member 1 Rattus norvegicus 124-129 31857643-10 2019 We found a novel cholesterol-lowering dipeptide FP that could improve cholesterol metabolism via the down-regulation of intestinal ABCA1. Cholesterol 17-28 ATP binding cassette subfamily A member 1 Rattus norvegicus 131-136 31857643-10 2019 We found a novel cholesterol-lowering dipeptide FP that could improve cholesterol metabolism via the down-regulation of intestinal ABCA1. Cholesterol 70-81 ATP binding cassette subfamily A member 1 Rattus norvegicus 131-136 31770672-3 2019 We have identified a novel long noncoding RNA (lncRNA), lnc-HC, which regulates hepatocytic cholesterol metabolism through reducing Cyp7a1 and Abca1 expression. Cholesterol 92-103 ATP binding cassette subfamily A member 1 Rattus norvegicus 143-148 31206670-4 2019 ADP-ribosylation factor 6 (Arf6) is a small GTPase with pleiotropic effects and has previously been shown to regulate ATP-binding cassette transporter 1 (ABCA1) recycling, and thus, cholesterol homeostasis. Cholesterol 182-193 ATP binding cassette subfamily A member 1 Rattus norvegicus 154-159 31206670-9 2019 Our results demonstrate that HG-induced cholesterol accumulation and cellular injury in podocytes may be related to the recycling disorder of ABCA1 caused by the downexpression of Arf6 in DKD. Cholesterol 40-51 ATP binding cassette subfamily A member 1 Rattus norvegicus 142-147 30201376-5 2018 The results in vitro experiment indicate that K-877 treatment increased levels of ABCA1 mRNA, as well as protein, subsequently reduced the cellular cholesterol content in INS-1 cells. Cholesterol 148-159 ATP binding cassette subfamily A member 1 Rattus norvegicus 82-87 30131353-2 2018 ABCA1 in pancreatic beta-cells influences insulin secretion and cholesterol homeostasis. Cholesterol 64-75 ATP binding cassette subfamily A member 1 Rattus norvegicus 0-5 30108153-0 2018 Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells. Cholesterol 23-34 ATP binding cassette subfamily A member 1 Rattus norvegicus 92-97 30108153-1 2018 In pancreatic beta cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis and insulin secretion. Cholesterol 69-80 ATP binding cassette subfamily A member 1 Rattus norvegicus 26-31 30013438-0 2018 Endothelial-cell inflammation and damage by reactive oxygen species are prevented by propofol via ABCA1-mediated cholesterol efflux. Cholesterol 113-124 ATP binding cassette subfamily A member 1 Rattus norvegicus 98-103 28859904-7 2018 Addition of exogenous cell-permeable cholesterol restored the effect of BPA on Abca1 and Star mRNA expression and partially reversed BPA"s effect on progesterone production. Cholesterol 37-48 ATP binding cassette subfamily A member 1 Rattus norvegicus 79-84 29375565-6 2017 In addition, PLD could activate LXRalpha-ABCA1 signaling pathway which induces cholesterol efflux from cells. Cholesterol 79-90 ATP binding cassette subfamily A member 1 Rattus norvegicus 41-46 29032333-6 2017 The alterations of miR-27a and ABCA1 resulting from incubation with cholesterol or GLP-1 were detected by real-time PCR and western blot. Cholesterol 68-79 ATP binding cassette subfamily A member 1 Rattus norvegicus 31-36 28660384-1 2017 Hepatic ATP-binding cassette A1 (ABCA1) transporter is the modulator of intrahepatic cholesterol levels via the efflux of cholesterol into plasma. Cholesterol 85-96 ATP binding cassette subfamily A member 1 Rattus norvegicus 8-31 28660384-1 2017 Hepatic ATP-binding cassette A1 (ABCA1) transporter is the modulator of intrahepatic cholesterol levels via the efflux of cholesterol into plasma. Cholesterol 85-96 ATP binding cassette subfamily A member 1 Rattus norvegicus 33-38 28660384-1 2017 Hepatic ATP-binding cassette A1 (ABCA1) transporter is the modulator of intrahepatic cholesterol levels via the efflux of cholesterol into plasma. Cholesterol 122-133 ATP binding cassette subfamily A member 1 Rattus norvegicus 8-31 28660384-1 2017 Hepatic ATP-binding cassette A1 (ABCA1) transporter is the modulator of intrahepatic cholesterol levels via the efflux of cholesterol into plasma. Cholesterol 122-133 ATP binding cassette subfamily A member 1 Rattus norvegicus 33-38 28660384-3 2017 A cholesterol efflux study was conducted with Abca1 knock down using siRNA in WIF9 cells. Cholesterol 2-13 ATP binding cassette subfamily A member 1 Rattus norvegicus 46-51 28660384-4 2017 Cholesterol levels in the ABCA1 siRNA cells in the medium were significantly decreased compared with those in controls (P < 0.05). Cholesterol 0-11 ATP binding cassette subfamily A member 1 Rattus norvegicus 26-31 28660384-10 2017 Upregulated hepatic ABCA1 may lead to efflux of cholesterol into plasma, thus explaining the mechanism of cholestasis leading to hypercholesterolemia. Cholesterol 48-59 ATP binding cassette subfamily A member 1 Rattus norvegicus 20-25 27693527-8 2016 A reduced gene expression of FXR-dependent SHP (a key gene for feedback inhibition of CYP7A1 and CYP8B1) and of bile acids (NTCP, OATP1A1, BSEP) and cholesterol (ABCA1) transporters was found. Cholesterol 149-160 ATP binding cassette subfamily A member 1 Rattus norvegicus 162-167 27522963-16 2016 Lastly, O3FA increased ATP-binding cassette transporter A1 (ABCA1) protein expression via silent information regulator 1 (SIRT1) activation, thus increasing cholesterol efflux from macrophages to HDL. Cholesterol 157-168 ATP binding cassette subfamily A member 1 Rattus norvegicus 23-58 27522963-16 2016 Lastly, O3FA increased ATP-binding cassette transporter A1 (ABCA1) protein expression via silent information regulator 1 (SIRT1) activation, thus increasing cholesterol efflux from macrophages to HDL. Cholesterol 157-168 ATP binding cassette subfamily A member 1 Rattus norvegicus 60-65 26743528-1 2016 ATP-binding cassette transporter A1 (ABCA1) in pancreatic beta cells influences insulin secretion and cholesterol homeostasis. Cholesterol 102-113 ATP binding cassette subfamily A member 1 Rattus norvegicus 0-35 26743528-1 2016 ATP-binding cassette transporter A1 (ABCA1) in pancreatic beta cells influences insulin secretion and cholesterol homeostasis. Cholesterol 102-113 ATP binding cassette subfamily A member 1 Rattus norvegicus 37-42 26707062-1 2016 ATP-binding cassette transporters A1 (ABCA1) and G1 (ABCG1), and macrophage scavenger receptor, cluster of differentiation (CD)36, function as key mediators of cholesterol efflux and influx from macrophages. Cholesterol 160-171 ATP binding cassette subfamily A member 1 Rattus norvegicus 38-43 25081040-2 2014 We had previously shown that ethanol up-regulates the levels of two cholesterol transporters, ABCA1 (ATP binding cassette-A1) and ABCG1, leading to increased cholesterol efflux and decreased cholesterol content in astrocytes in vitro. Cholesterol 68-79 ATP binding cassette subfamily A member 1 Rattus norvegicus 94-99 25081040-2 2014 We had previously shown that ethanol up-regulates the levels of two cholesterol transporters, ABCA1 (ATP binding cassette-A1) and ABCG1, leading to increased cholesterol efflux and decreased cholesterol content in astrocytes in vitro. Cholesterol 68-79 ATP binding cassette subfamily A member 1 Rattus norvegicus 101-124 25081040-2 2014 We had previously shown that ethanol up-regulates the levels of two cholesterol transporters, ABCA1 (ATP binding cassette-A1) and ABCG1, leading to increased cholesterol efflux and decreased cholesterol content in astrocytes in vitro. Cholesterol 158-169 ATP binding cassette subfamily A member 1 Rattus norvegicus 94-99 25081040-2 2014 We had previously shown that ethanol up-regulates the levels of two cholesterol transporters, ABCA1 (ATP binding cassette-A1) and ABCG1, leading to increased cholesterol efflux and decreased cholesterol content in astrocytes in vitro. Cholesterol 158-169 ATP binding cassette subfamily A member 1 Rattus norvegicus 101-124 24814386-0 2014 Astrocyte s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1. Cholesterol 89-100 ATP binding cassette subfamily A member 1 Rattus norvegicus 126-131 24814386-10 2014 These findings suggest that endogenous apoE generates lower density HDL to produce more lipidated HDL using previously synthesized cholesterol through the interaction with ABCA1 in caveolin-1-rich domain of astrocytes. Cholesterol 131-142 ATP binding cassette subfamily A member 1 Rattus norvegicus 172-177 24446142-1 2014 Activation of cdc42 reportedly enhances apoA-I-mediated cholesterol release through ATP-binding cassette transporter A1 (ABCA1). Cholesterol 56-67 ATP binding cassette subfamily A member 1 Rattus norvegicus 84-119 24446142-1 2014 Activation of cdc42 reportedly enhances apoA-I-mediated cholesterol release through ATP-binding cassette transporter A1 (ABCA1). Cholesterol 56-67 ATP binding cassette subfamily A member 1 Rattus norvegicus 121-126 24446142-2 2014 We examined the involvement of cdc42 and Rho kinase in intracellular cholesterol transport for release of cholesterol after the interaction between apoA-I and ABCA1 in astrocytes. Cholesterol 69-80 ATP binding cassette subfamily A member 1 Rattus norvegicus 159-164 24446142-6 2014 These findings suggest that cdc42 is activated by the interaction between apoA-I and ABCA1 and enhances cholesterol release through the activation of Rho kinase. Cholesterol 104-115 ATP binding cassette subfamily A member 1 Rattus norvegicus 85-90 24446142-10 2014 We conclude that ABCA1/cdc42/Rho kinase signaling is involved in apoA-I-induced intracellular cholesterol transport and apoA-I-mediated cholesterol release in rat astrocytes. Cholesterol 94-105 ATP binding cassette subfamily A member 1 Rattus norvegicus 17-22 24446142-10 2014 We conclude that ABCA1/cdc42/Rho kinase signaling is involved in apoA-I-induced intracellular cholesterol transport and apoA-I-mediated cholesterol release in rat astrocytes. Cholesterol 136-147 ATP binding cassette subfamily A member 1 Rattus norvegicus 17-22 24291698-10 2014 The LXR-beta/RXR-alpha/ABCA1 mediated apo A1 cholesterol may play a protective effect, and the effect only exists in a certain period of time. Cholesterol 45-56 ATP binding cassette subfamily A member 1 Rattus norvegicus 23-28 25197575-1 2014 Exogenous apolipoprotein A-I (apoA-I) associates with ATP-binding cassette transporter A1 (ABCA1) on the cell surface of astrocytes like various peripheral cells and enhances the translocation of newly synthesized cholesterol from the endoplasmic reticulum/Golgi apparatus (ER/Golgi) to the cytosol. Cholesterol 214-225 ATP binding cassette subfamily A member 1 Rattus norvegicus 91-96 23674092-1 2013 Liver X receptor alpha (LXRalpha) is a member of the ligand-activated transcription factor of nuclear hormonal receptor superfamily, whose activation leads to modulation in the expression of genes involved in cholesterol homeostasis including ATP-binding cassette transporter A1 (ABCA1), which plays a crucial role in plasma high-density lipoprotein cholesterol (HDL-C) remodeling. Cholesterol 209-220 ATP binding cassette subfamily A member 1 Rattus norvegicus 243-278 23674092-1 2013 Liver X receptor alpha (LXRalpha) is a member of the ligand-activated transcription factor of nuclear hormonal receptor superfamily, whose activation leads to modulation in the expression of genes involved in cholesterol homeostasis including ATP-binding cassette transporter A1 (ABCA1), which plays a crucial role in plasma high-density lipoprotein cholesterol (HDL-C) remodeling. Cholesterol 209-220 ATP binding cassette subfamily A member 1 Rattus norvegicus 280-285 23147682-10 2013 Conversely, beta-carotene significantly enhanced the expression levels of genes related to cholesterol regulation, including Abca1, Abcg1, Hmgcr as well as Apoe. Cholesterol 91-102 ATP binding cassette subfamily A member 1 Rattus norvegicus 125-130 23185768-16 2012 CONCLUSIONS: EA at ST40 could obviously down-regulate the levels of TC and LDL-C in hyperlipidemia rats, up-regulate the expressions of ABCA1 and PPARalpha, thus promoting counter transport of cholesterol. Cholesterol 193-204 ATP binding cassette subfamily A member 1 Rattus norvegicus 136-141 22668787-3 2012 We first observed that cardiomyocytes poorly internalized exogenously supplied native or modified LDL and that free cholesterol (FC) efflux to free apolipoprotein AI (apo AI) and to HDL was mediated by ATP binding cassette transporter A1 (ABCA1) and likely by ATP binding cassette transporter G1 (ABCG1), respectively, which are both upregulated by liver X receptor/retinoid X receptor (LXR/RXR) activation. Cholesterol 116-127 ATP binding cassette subfamily A member 1 Rattus norvegicus 202-237 22668787-3 2012 We first observed that cardiomyocytes poorly internalized exogenously supplied native or modified LDL and that free cholesterol (FC) efflux to free apolipoprotein AI (apo AI) and to HDL was mediated by ATP binding cassette transporter A1 (ABCA1) and likely by ATP binding cassette transporter G1 (ABCG1), respectively, which are both upregulated by liver X receptor/retinoid X receptor (LXR/RXR) activation. Cholesterol 116-127 ATP binding cassette subfamily A member 1 Rattus norvegicus 239-244 22705727-11 2012 The decreased free cholesterol level in the peripheral tissues may be partly due to the increased expression of the ABCA1 protein. Cholesterol 19-30 ATP binding cassette subfamily A member 1 Rattus norvegicus 116-121 22001232-2 2012 Individuals with Tangier disease also have elevated plasma TG concentrations and a near absence of HDL, resulting from mutations in ATP binding cassette transporter A1 (ABCA1), which facilitates the efflux of cellular phospholipid and free cholesterol to assemble with apolipoprotein A-I (apoA-I), forming nascent HDL particles. Cholesterol 240-251 ATP binding cassette subfamily A member 1 Rattus norvegicus 132-167 22001232-2 2012 Individuals with Tangier disease also have elevated plasma TG concentrations and a near absence of HDL, resulting from mutations in ATP binding cassette transporter A1 (ABCA1), which facilitates the efflux of cellular phospholipid and free cholesterol to assemble with apolipoprotein A-I (apoA-I), forming nascent HDL particles. Cholesterol 240-251 ATP binding cassette subfamily A member 1 Rattus norvegicus 169-174 21306558-1 2011 Apolipoprotein A-I (ApoA-I) is an extracellular lipid acceptor, whose role in cholesterol efflux and high-density lipoprotein formation is mediated by ATP-binding cassette transporter A1 (ABCA1). Cholesterol 78-89 ATP binding cassette subfamily A member 1 Rattus norvegicus 151-186 21306558-1 2011 Apolipoprotein A-I (ApoA-I) is an extracellular lipid acceptor, whose role in cholesterol efflux and high-density lipoprotein formation is mediated by ATP-binding cassette transporter A1 (ABCA1). Cholesterol 78-89 ATP binding cassette subfamily A member 1 Rattus norvegicus 188-193 21866950-8 2011 In addition, 7PA increased (P<0.05) expression and protein levels of ATP-binding cassette transporter A1 (ABCA1), which facilitates cholesterol efflux and reduces cholesterol accumulation in macrophages. Cholesterol 135-146 ATP binding cassette subfamily A member 1 Rattus norvegicus 72-107 21866950-8 2011 In addition, 7PA increased (P<0.05) expression and protein levels of ATP-binding cassette transporter A1 (ABCA1), which facilitates cholesterol efflux and reduces cholesterol accumulation in macrophages. Cholesterol 135-146 ATP binding cassette subfamily A member 1 Rattus norvegicus 109-114 21866950-8 2011 In addition, 7PA increased (P<0.05) expression and protein levels of ATP-binding cassette transporter A1 (ABCA1), which facilitates cholesterol efflux and reduces cholesterol accumulation in macrophages. Cholesterol 166-177 ATP binding cassette subfamily A member 1 Rattus norvegicus 72-107 21866950-8 2011 In addition, 7PA increased (P<0.05) expression and protein levels of ATP-binding cassette transporter A1 (ABCA1), which facilitates cholesterol efflux and reduces cholesterol accumulation in macrophages. Cholesterol 166-177 ATP binding cassette subfamily A member 1 Rattus norvegicus 109-114 21605865-0 2011 Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter. Cholesterol 65-76 ATP binding cassette subfamily A member 1 Rattus norvegicus 85-90 21605865-5 2011 J774 macrophages, BHK cells, and Fu5AH rat hepatoma cells were used to measure cholesterol efflux mediated by ABCA1, ABCG1 transporters or SR-BI. Cholesterol 79-90 ATP binding cassette subfamily A member 1 Rattus norvegicus 110-115 21605865-8 2011 CONCLUSIONS: Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter. Cholesterol 78-89 ATP binding cassette subfamily A member 1 Rattus norvegicus 98-103 21628419-5 2011 13-cis-RA and 9-cis-RA also significantly increased mRNA levels of Abca1 (maximal induction 7.3 +- 0.42 and 2.7 +- 0.17, respectively) and Abcg1 (maximal induction 2.0 +- 0.18 and 1.8 +- 0.09, respectively), and the levels of membrane-bound Abca1 (2.5 +- 0.3 and 2.5 +- 0.40-fold increase, respectively), whereas they significantly decreased intracellular cholesterol content without affecting cholesterol synthesis. Cholesterol 356-367 ATP binding cassette subfamily A member 1 Rattus norvegicus 67-72 21628419-5 2011 13-cis-RA and 9-cis-RA also significantly increased mRNA levels of Abca1 (maximal induction 7.3 +- 0.42 and 2.7 +- 0.17, respectively) and Abcg1 (maximal induction 2.0 +- 0.18 and 1.8 +- 0.09, respectively), and the levels of membrane-bound Abca1 (2.5 +- 0.3 and 2.5 +- 0.40-fold increase, respectively), whereas they significantly decreased intracellular cholesterol content without affecting cholesterol synthesis. Cholesterol 394-405 ATP binding cassette subfamily A member 1 Rattus norvegicus 67-72 20480185-8 2010 Lipid metabolism involved in renal reverse cholesterol transport may be mediated by decreasing the signaling through the ABCA1 cholesterol efflux pathway, which is significantly modified in kidneys of vitamin A-deficient rats. Cholesterol 127-138 ATP binding cassette subfamily A member 1 Rattus norvegicus 121-126 20480185-5 2010 Compared with the control, VAD rats had significantly higher levels of transforming growth factor-beta 1 and lower levels of ABCA1, a key gene involved in cholesterol efflux and tissue lipid homeostasis. Cholesterol 155-166 ATP binding cassette subfamily A member 1 Rattus norvegicus 125-130 20480185-8 2010 Lipid metabolism involved in renal reverse cholesterol transport may be mediated by decreasing the signaling through the ABCA1 cholesterol efflux pathway, which is significantly modified in kidneys of vitamin A-deficient rats. Cholesterol 43-54 ATP binding cassette subfamily A member 1 Rattus norvegicus 121-126 20584649-7 2010 CONCLUSIONS: Treatment of BMCS-SMCs with ox-LDL results in cholesterol ester accumulation in the cells to result in foam cells, the mechanism of which involves up-regulation of scavenger receptor SR-A expression and down-regulation of the reverse cholesterol transport protein ABCA1 and caveolin-1 expression. Cholesterol 59-70 ATP binding cassette subfamily A member 1 Rattus norvegicus 277-282 19860851-7 2010 The results suggest that increased cholesterol biosynthesis and loss of ABCA1 expression in injured neurons might result in increase in cholesterol in the degenerating hippocampus. Cholesterol 136-147 ATP binding cassette subfamily A member 1 Rattus norvegicus 72-77 19275878-0 2009 ABCA1 modulates the oligomerization and Golgi exit of caveolin-1 during HDL-mediated cholesterol efflux in aortic endothelial cells. Cholesterol 85-96 ATP binding cassette subfamily A member 1 Rattus norvegicus 0-5 19275878-1 2009 Previously, the authors have shown that the molecular interaction between caveolin-1 and ATP-binding cassette transporter A1 (ABCA1) is associated with the high-density lipoprotein (HDL)-mediated cholesterol efflux pathway in aortic endothelial cells (ECs). Cholesterol 196-207 ATP binding cassette subfamily A member 1 Rattus norvegicus 89-124 19275878-1 2009 Previously, the authors have shown that the molecular interaction between caveolin-1 and ATP-binding cassette transporter A1 (ABCA1) is associated with the high-density lipoprotein (HDL)-mediated cholesterol efflux pathway in aortic endothelial cells (ECs). Cholesterol 196-207 ATP binding cassette subfamily A member 1 Rattus norvegicus 126-131 19275878-2 2009 This study analyzed the role ABCA1 plays in caveolin-1-mediated cholesterol efflux in aortic ECs. Cholesterol 64-75 ATP binding cassette subfamily A member 1 Rattus norvegicus 29-34 19275878-3 2009 Knockdown of ABCA1 by siRNA in primary rat aortic ECs after cholesterol treatment did not affect caveolin-1 expression but led to the retention of caveolin-1 in the Golgi apparatus, impaired caveolin-1 oligomerization, and reduced cholesterol efflux. Cholesterol 60-71 ATP binding cassette subfamily A member 1 Rattus norvegicus 13-18 19275878-3 2009 Knockdown of ABCA1 by siRNA in primary rat aortic ECs after cholesterol treatment did not affect caveolin-1 expression but led to the retention of caveolin-1 in the Golgi apparatus, impaired caveolin-1 oligomerization, and reduced cholesterol efflux. Cholesterol 231-242 ATP binding cassette subfamily A member 1 Rattus norvegicus 13-18 19275878-6 2009 It is concluded that HDL up-regulates ABCA1 expression, which in turn modulates the oligomerization and Golgi exit of caveolin-1 to enhance cholesterol efflux in aortic ECs. Cholesterol 140-151 ATP binding cassette subfamily A member 1 Rattus norvegicus 38-43 19321994-3 2009 HDL mitigates atherosclerosis by retrieving surplus cholesterol via ATP binding cassette transporter A1 (ABCA1) and ABCG1 transporters whose expression is regulated by liver X receptor (LXR). Cholesterol 52-63 ATP binding cassette subfamily A member 1 Rattus norvegicus 68-103 19321994-3 2009 HDL mitigates atherosclerosis by retrieving surplus cholesterol via ATP binding cassette transporter A1 (ABCA1) and ABCG1 transporters whose expression is regulated by liver X receptor (LXR). Cholesterol 52-63 ATP binding cassette subfamily A member 1 Rattus norvegicus 105-110 17884990-2 2008 The processes may involve the ATP-binding cassette transporter A1 (ABCA1), a transport protein shown to be crucial in apolipoprotein A-I (apoA-I)-mediated mobilization of cellular cholesterol and phospholipid. Cholesterol 180-191 ATP binding cassette subfamily A member 1 Rattus norvegicus 30-65 17884990-2 2008 The processes may involve the ATP-binding cassette transporter A1 (ABCA1), a transport protein shown to be crucial in apolipoprotein A-I (apoA-I)-mediated mobilization of cellular cholesterol and phospholipid. Cholesterol 180-191 ATP binding cassette subfamily A member 1 Rattus norvegicus 67-72 17499231-0 2007 Molecular interaction between caveolin-1 and ABCA1 on high-density lipoprotein-mediated cholesterol efflux in aortic endothelial cells. Cholesterol 88-99 ATP binding cassette subfamily A member 1 Rattus norvegicus 45-50 17499231-1 2007 OBJECTIVE: Caveolin-1 and ATP-binding cassette transporter A1 (ABCA1) are proteins that are involved in cellular cholesterol efflux. Cholesterol 113-124 ATP binding cassette subfamily A member 1 Rattus norvegicus 26-61 17499231-1 2007 OBJECTIVE: Caveolin-1 and ATP-binding cassette transporter A1 (ABCA1) are proteins that are involved in cellular cholesterol efflux. Cholesterol 113-124 ATP binding cassette subfamily A member 1 Rattus norvegicus 63-68 17499231-2 2007 In this study, we analyzed the relationships between caveolin-1 and ABCA1 on high-density lipoprotein (HDL)-mediated cholesterol efflux in rat aortic endothelial cells. Cholesterol 117-128 ATP binding cassette subfamily A member 1 Rattus norvegicus 68-73 17499231-7 2007 Immunoelectron microscopy demonstrated that caveolin-1 colocalized with ABCA1 in the caveolae and in the cytoplasmic vesicles; it was also found that caveolin-1 and ABCA1 colocalized with cellular cholesterol by immunofluorescence microscopy. Cholesterol 197-208 ATP binding cassette subfamily A member 1 Rattus norvegicus 165-170 17499231-9 2007 CONCLUSIONS: The molecular interaction between caveolin-1 and ABCA1 is associated with the HDL-mediated cholesterol efflux pathway in aortic endothelial cells. Cholesterol 104-115 ATP binding cassette subfamily A member 1 Rattus norvegicus 62-67 17526932-0 2007 Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. Cholesterol 198-209 ATP binding cassette subfamily A member 1 Rattus norvegicus 109-127 17526932-3 2007 In peripheral cells ABCA1 is up-regulated by the liver X receptor (LXR) system when cell cholesterol increases. Cholesterol 89-100 ATP binding cassette subfamily A member 1 Rattus norvegicus 20-25 17526932-11 2007 We conclude that the dual promoter system driven by SREBP-2 and LXR regulates hepatic ABCA1 expression and may mediate the unique response of hepatic ABCA1 gene expression to cellular cholesterol status. Cholesterol 184-195 ATP binding cassette subfamily A member 1 Rattus norvegicus 86-91 17526932-11 2007 We conclude that the dual promoter system driven by SREBP-2 and LXR regulates hepatic ABCA1 expression and may mediate the unique response of hepatic ABCA1 gene expression to cellular cholesterol status. Cholesterol 184-195 ATP binding cassette subfamily A member 1 Rattus norvegicus 150-155 17101031-0 2007 24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression. Cholesterol 11-22 ATP binding cassette subfamily A member 1 Rattus norvegicus 172-177 17101031-8 2007 These results suggest that LXR activation facilitates cholesterol release into the CSF from CPE through the functional induction of ABCA1 and ABCG1. Cholesterol 54-65 ATP binding cassette subfamily A member 1 Rattus norvegicus 132-137