PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29111006-4 2017 ATP-binding cassette transporter A7 (ABCA7) gene, regulating the transport of cholesterol, has been recently identified as a susceptible gene of AD by several large genome-wide association studies. Cholesterol 78-89 ATP binding cassette subfamily A member 7 Homo sapiens 0-35 33221536-3 2021 When transfected and expressed, ABCA7 also mediates generation of HDL-like particles but small and of less cholesterol content. Cholesterol 107-118 ATP binding cassette subfamily A member 7 Homo sapiens 32-37 33221536-7 2021 In contrast, ABCA7 expression was shown to be regulated negatively by the SREBP system so that decrease of cell cholesterol enhances ABCA7 function such as cellular phagocytotic reaction, suggesting that it links cholesterol metabolism to the host defense system. Cholesterol 112-123 ATP binding cassette subfamily A member 7 Homo sapiens 13-18 33221536-7 2021 In contrast, ABCA7 expression was shown to be regulated negatively by the SREBP system so that decrease of cell cholesterol enhances ABCA7 function such as cellular phagocytotic reaction, suggesting that it links cholesterol metabolism to the host defense system. Cholesterol 112-123 ATP binding cassette subfamily A member 7 Homo sapiens 133-138 33221536-7 2021 In contrast, ABCA7 expression was shown to be regulated negatively by the SREBP system so that decrease of cell cholesterol enhances ABCA7 function such as cellular phagocytotic reaction, suggesting that it links cholesterol metabolism to the host defense system. Cholesterol 213-224 ATP binding cassette subfamily A member 7 Homo sapiens 13-18 33221536-10 2021 Accordingly, modulation of ABCA7 activity by manipulating cholesterol metabolism may open a new path for management of Alzheimer"s disease. Cholesterol 58-69 ATP binding cassette subfamily A member 7 Homo sapiens 27-32 32745159-4 2020 Regarding the transversal analysis, the ABCA7 rs2279796 GG genotype was associated with higher levels of total cholesterol and LDL-c at baseline (p = 0.044 for both). Cholesterol 111-122 ATP binding cassette subfamily A member 7 Homo sapiens 40-45 33215389-6 2021 The review highlights different families of ABC transporters, ABCB1 (P-glycoprotein), ABCA (ABCA1, ABCA2, and ABCA7), ABCG2 (BCRP; breast cancer resistance protein), ABCG1 and ABCG4, as well as ABCC1 (MRP; multidrug resistance protein) in the CNS, and their interplay in regulating cholesterol metabolism and Abeta peptide load in the brain, simultaneously exerting protective effects against neurotoxic substrates and xenobiotics. Cholesterol 282-293 ATP binding cassette subfamily A member 7 Homo sapiens 110-115 29111006-4 2017 ATP-binding cassette transporter A7 (ABCA7) gene, regulating the transport of cholesterol, has been recently identified as a susceptible gene of AD by several large genome-wide association studies. Cholesterol 78-89 ATP binding cassette subfamily A member 7 Homo sapiens 37-42 23328907-3 2013 The findings are supported by genetic linkage and association studies that have clearly identified several genes involved in cholesterol metabolism or transport as AD susceptibility genes, including apolipoprotein E (APOE), apolipoprotein J (APOJ, CLU), ATP-binding cassette subfamily A member 7(ABCA7), and sortilin-related receptor (SORL1). Cholesterol 125-136 ATP binding cassette subfamily A member 7 Homo sapiens 254-295 23462326-10 2013 The up-regulation of ABCA1, ABCA7, and ABCG1 implicates a serious impairment of cellular cholesterol homeostasis in PDAC. Cholesterol 89-100 ATP binding cassette subfamily A member 7 Homo sapiens 28-33 23328907-3 2013 The findings are supported by genetic linkage and association studies that have clearly identified several genes involved in cholesterol metabolism or transport as AD susceptibility genes, including apolipoprotein E (APOE), apolipoprotein J (APOJ, CLU), ATP-binding cassette subfamily A member 7(ABCA7), and sortilin-related receptor (SORL1). Cholesterol 125-136 ATP binding cassette subfamily A member 7 Homo sapiens 296-301 17029687-7 2006 Enhanced expression of ABCA2 and related proteins, including ABCA1, ABCA4 and ABCA7, is found in human macrophages upon bolus cholesterol treatment. Cholesterol 126-137 ATP binding cassette subfamily A member 7 Homo sapiens 78-83 23324282-1 2013 BACKGROUND: ABCA7 is a member of the ABCA subfamily that shows a high degree of homology to ABCA1 and, like ABCA1, mediates cellular cholesterol and phospholipid release by apolipoproteins when transfected in vitro. Cholesterol 133-144 ATP binding cassette subfamily A member 7 Homo sapiens 12-17 23324282-2 2013 However, expression of ABCA7 has been shown to be downregulated by increased cellular cholesterol while ABCA1 was upregulated. Cholesterol 86-97 ATP binding cassette subfamily A member 7 Homo sapiens 23-28 18429932-4 2008 This study investigated the ability of ABCA7 to regulate cholesterol efflux to extracellular apolipoprotein acceptors and to modulate Abeta production. Cholesterol 57-68 ATP binding cassette subfamily A member 7 Homo sapiens 39-44 18429932-5 2008 The transient expression of ABCA7 in human embryonic kidney cells significantly stimulated cholesterol efflux (fourfold) to apolipoprotein E (apoE) discoidal lipid complexes but not to lipid-free apoE or apoA-I. Cholesterol 91-102 ATP binding cassette subfamily A member 7 Homo sapiens 28-33 18429932-9 2008 These studies indicate that ABCA7 has the capacity to stimulate cellular cholesterol efflux to apoE discs and regulate APP processing resulting in an inhibition of Abeta production. Cholesterol 73-84 ATP binding cassette subfamily A member 7 Homo sapiens 28-33 17266523-7 2007 This transporter, along with other proteins that have a high degree of homology to ABCA2, including ABCA1 and ABCA7, are up-regulated in human macrophages during cholesterol import. Cholesterol 162-173 ATP binding cassette subfamily A member 7 Homo sapiens 110-115 14570867-4 2004 Time-dependent release of cholesterol and phospholipid by apolipoprotein A (apoA)-I was parallel both with ABCA1 and with ABCA7 when highly expressed in HEK293 cells, but dose-dependent profiles of lipid release on apoA-I and apoA-II were somewhat different between ABCA1 and ABCA7. Cholesterol 26-37 ATP binding cassette subfamily A member 7 Homo sapiens 276-281 15930518-8 2005 The increase of HDL assembly with the increase of ABCA1 expression was predominant in large cholesterol-rich particles, whereas only small cholesterol-poor HDL increased as ABCA7 expression increased. Cholesterol 139-150 ATP binding cassette subfamily A member 7 Homo sapiens 173-178 14570867-0 2004 Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein. Cholesterol 65-76 ATP binding cassette subfamily A member 7 Homo sapiens 6-11 14570867-1 2004 Apolipoprotein-mediated release of cellular cholesterol and phospholipids was induced in HEK293 cells by expressing human ATP-binding cassette transporter A7 (ABCA7) and ABC transporter A1 (ABCA1) proteins, whether transient or stable, to generate cholesterol-rich high density lipoprotein (HDL). Cholesterol 44-55 ATP binding cassette subfamily A member 7 Homo sapiens 122-157 16607034-5 2006 SAA reacted with the HEK293-derived clones that stably express human ABCA1 (293/2c) or ABCA7 (293/6c) to generate cholesterol-containing HDL in a similar manner to apoA-I. Cholesterol 114-125 ATP binding cassette subfamily A member 7 Homo sapiens 87-92 16607034-9 2006 These results demonstrate that SAA generates cholesterol-containing HDL directly with cellular lipid and that the reaction is mediated by ABCA1 and ABCA7. Cholesterol 45-56 ATP binding cassette subfamily A member 7 Homo sapiens 148-153 16185294-1 2005 ABCA7 is a member of the subfamily A of adenosine triphosphate-binding cassette (ABC) proteins, and highly homologous to ABCA1, which mediates the release of cellular cholesterol and phospholipid to form high-density lipoprotein. Cholesterol 167-178 ATP binding cassette subfamily A member 7 Homo sapiens 0-5 15347662-8 2004 Chimeric transporters, generated by substituting the C termini of either ABCA4 or ABCA7 for the endogenous terminus, demonstrated that ABCA1 could stimulate cholesterol efflux without its PDZ-binding motif but not without the VFVNFA motif. Cholesterol 157-168 ATP binding cassette subfamily A member 7 Homo sapiens 82-87 14570867-1 2004 Apolipoprotein-mediated release of cellular cholesterol and phospholipids was induced in HEK293 cells by expressing human ATP-binding cassette transporter A7 (ABCA7) and ABC transporter A1 (ABCA1) proteins, whether transient or stable, to generate cholesterol-rich high density lipoprotein (HDL). Cholesterol 44-55 ATP binding cassette subfamily A member 7 Homo sapiens 159-164 14570867-1 2004 Apolipoprotein-mediated release of cellular cholesterol and phospholipids was induced in HEK293 cells by expressing human ATP-binding cassette transporter A7 (ABCA7) and ABC transporter A1 (ABCA1) proteins, whether transient or stable, to generate cholesterol-rich high density lipoprotein (HDL). Cholesterol 248-259 ATP binding cassette subfamily A member 7 Homo sapiens 122-157 14570867-1 2004 Apolipoprotein-mediated release of cellular cholesterol and phospholipids was induced in HEK293 cells by expressing human ATP-binding cassette transporter A7 (ABCA7) and ABC transporter A1 (ABCA1) proteins, whether transient or stable, to generate cholesterol-rich high density lipoprotein (HDL). Cholesterol 248-259 ATP binding cassette subfamily A member 7 Homo sapiens 159-164 14570867-4 2004 Time-dependent release of cholesterol and phospholipid by apolipoprotein A (apoA)-I was parallel both with ABCA1 and with ABCA7 when highly expressed in HEK293 cells, but dose-dependent profiles of lipid release on apoA-I and apoA-II were somewhat different between ABCA1 and ABCA7. Cholesterol 26-37 ATP binding cassette subfamily A member 7 Homo sapiens 122-127 14570867-11 2004 The data indicated that human ABCA7 would compensate the function of ABCA1 for release of cell cholesterol in a certain condition(s), but post-transcriptional regulation of their activity is different. Cholesterol 95-106 ATP binding cassette subfamily A member 7 Homo sapiens 30-35 12917409-0 2003 ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. Cholesterol 112-123 ATP binding cassette subfamily A member 7 Homo sapiens 0-35 14592415-6 2003 HEK293 cells expressing type I ABCA7 showed apoA-I-dependent cholesterol and phospholipid release. Cholesterol 61-72 ATP binding cassette subfamily A member 7 Homo sapiens 31-36 12917409-0 2003 ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. Cholesterol 112-123 ATP binding cassette subfamily A member 7 Homo sapiens 37-42 12917409-7 2003 These studies show that ABCA7 has the ability to bind apolipoproteins and promote efflux of cellular phospholipids without cholesterol, and they suggest a possible role of ABCA7 in cellular phospholipid metabolism in peripheral tissues. Cholesterol 123-134 ATP binding cassette subfamily A member 7 Homo sapiens 24-29 11178988-4 2001 Among the known members of the ABC A subfamily ABCA2 shares highest homology with the cholesterol-responsive transporters ABCA1 (50%) and the recently cloned ABCA7 (44%). Cholesterol 86-97 ATP binding cassette subfamily A member 7 Homo sapiens 158-163 11095984-0 2000 Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. Cholesterol 34-45 ATP binding cassette subfamily A member 7 Homo sapiens 73-78