PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31975555-6 2020 High-level hepatic MsrA significantly reduced the plasma free cholesterol contents, improved HDL functional proteins apolipoprotein A-I (apoAI), apoE, paraoxonase1 (PON1), and lecithin:cholesterol acyltransferase (LCAT), while decreased the pro-inflammatory property of dysfunctional HDL, contributing to reduced atherosclerosis and hepatic steatosis in Western diet-fed mice. Cholesterol 62-73 methionine sulfoxide reductase A Mus musculus 19-23 9069289-1 1997 Macrophage type-I and type-II class-A scavenger receptors (MSR-A) are implicated in the pathological deposition of cholesterol during atherogenesis as a result of receptor-mediated uptake of modified low-density lipoproteins (mLDL). Cholesterol 115-126 methionine sulfoxide reductase A Mus musculus 59-64 31975555-7 2020 Furthermore, the study revealed that hepatic MsrA altered the expression of several genes controlling HDL biogenesis, cholesterol esterification, cholesterol uptake mediated by low-density lipoprotein receptor (LDLR) and biliary excretion, as well as suppressed nuclear factor kappaB (NF-kappaB) signaling pathway, which largely relied on liver X receptor alpha (LXRalpha)-upregulation. Cholesterol 118-129 methionine sulfoxide reductase A Mus musculus 45-49 31975555-7 2020 Furthermore, the study revealed that hepatic MsrA altered the expression of several genes controlling HDL biogenesis, cholesterol esterification, cholesterol uptake mediated by low-density lipoprotein receptor (LDLR) and biliary excretion, as well as suppressed nuclear factor kappaB (NF-kappaB) signaling pathway, which largely relied on liver X receptor alpha (LXRalpha)-upregulation. Cholesterol 146-157 methionine sulfoxide reductase A Mus musculus 45-49