PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31797978-0 2019 Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation. Cholesterol 41-52 sphingosine kinase 2 Mus musculus 0-20 28082351-3 2017 In this study, administration of clinically relevant doses of FTY720 to mice increased expression of NPC1 and -2 in brain and liver and decreased cholesterol in an SphK2-dependent manner. Cholesterol 146-157 sphingosine kinase 2 Mus musculus 164-169 31641049-7 2019 Inhibition of the endosomal cholesterol exporter NPC1 greatly reduced sphingosine phosphorylation in glial cells, linking loss of SK2 activity and S1P in AD to perturbed endosomal lipid metabolism. Cholesterol 28-39 sphingosine kinase 2 Mus musculus 130-133