PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34838043-0 2021 Phospholipase A2 group IIA correlates with circulating high-density lipoprotein cholesterol and modulates cholesterol efflux possibly through regulation of PPAR-gamma/LXR-alpha/ABCA1 in macrophages. Cholesterol 106-117 nuclear receptor subfamily 1 group H member 3 Homo sapiens 167-176 34838043-12 2021 CONCLUSIONS: Circulating sPLA2-IIA was positively associated with HDL-C. PPAR-gamma/LXR-alpha/ABCA1 might be responsible for sPLA2-IIA-regulated cholesterol efflux in macrophages. Cholesterol 145-156 nuclear receptor subfamily 1 group H member 3 Homo sapiens 84-93 34995504-8 2022 At a GWAS signal for high-density lipoprotein cholesterol colocalized with an NR1H3 sQTL splice junction, we show that the alternative splice product encodes an NR1H3 transcription factor that lacks a DNA binding domain and fails to activate transcription. Cholesterol 46-57 nuclear receptor subfamily 1 group H member 3 Homo sapiens 161-166 34212313-0 2021 Hesperetin inhibits foam cell formation and promotes cholesterol efflux in THP-1-derived macrophages by activating LXRalpha signal in an AMPK-dependent manner. Cholesterol 53-64 nuclear receptor subfamily 1 group H member 3 Homo sapiens 115-123 35533584-4 2022 mRNA expression levels of the steroidogenic (StAR, CYP11A1, and HSD3B1) and cholesterol uptake receptors (SCARB1 and LDLR) and LXR pathway (NR1H3, NR1H2, ABCA1, and ABCG1) were assessed using quantitative PCR (qPCR), and protein of LXR pathway was investigated using western blot. Cholesterol 76-87 nuclear receptor subfamily 1 group H member 3 Homo sapiens 140-145 34301759-8 2021 AR nuclear translocation was inhibited by activation of Liver X Receptor (LXR)-beta, the master regulator of cholesterol homeostasis. Cholesterol 109-120 nuclear receptor subfamily 1 group H member 3 Homo sapiens 56-83 34436503-3 2021 To further assess the detailed mechanisms between cholesterol metabolism, ER stress, and EMT, LXR-623 (an agonist of LXRalpha) and simvastatin were used to increase and decrease cholesterol efflux and synthesis, respectively. Cholesterol 178-189 nuclear receptor subfamily 1 group H member 3 Homo sapiens 117-125 34436503-4 2021 Here, we found that high HP-beta-CD concentrations could locally increase cholesterol levels in the ER by decreasing LXRalpha expression and increasing Hydroxymethylglutaryl-Coenzyme A reductase (HMGCR) expression in MDA-MB-231 and BT-549 cells, which triggered ER stress and inhibited EMT. Cholesterol 74-85 nuclear receptor subfamily 1 group H member 3 Homo sapiens 117-125 34212313-10 2021 This activation upregulats LXRalpha and its targets, including ABCA1, ABCG1 and SR-BI, which significantly inhibits foam cell formation and promotes cholesterol efflux. Cholesterol 149-160 nuclear receptor subfamily 1 group H member 3 Homo sapiens 27-35 35469913-4 2022 AIMS: Here, we aimed to attenuate increased NAD(P)H levels by stimulation of ATP-dependent cassette (ABC)A1 and ABCG1-mediated cellular cholesterol efflux with various PPARalpha and LXRalpha agonists. Cholesterol 136-147 nuclear receptor subfamily 1 group H member 3 Homo sapiens 182-190 33453241-4 2021 The present study investigates whether testosterone exerts anti-atherogenic effects by stimulating cholesterol clearance from macrophages via activation of liver X receptor (LXRalpha), a nuclear master regulator of cellular cholesterol homeostasis, lipid regulation, and inflammation. Cholesterol 99-110 nuclear receptor subfamily 1 group H member 3 Homo sapiens 174-182 33667626-6 2021 On the contrary, compared to systemic arterial monocytes, in coronary microenvironment of NSTEMI patients after myocardial infarction, the monocytes exhibited a higher mRNA expression of nuclear receptor LXRalpha and its targets ABCA1 and APOE, which drive cholesterol efflux capacity. Cholesterol 257-268 nuclear receptor subfamily 1 group H member 3 Homo sapiens 204-212 33631191-12 2021 Knock-down of liver X receptor alpha (LXRalpha) but not Sirt1 by siRNA significantly blocked RSV-induced cholesterol excretion in Caco-2 cells. Cholesterol 105-116 nuclear receptor subfamily 1 group H member 3 Homo sapiens 38-46 33453241-0 2021 Testosterone stimulates cholesterol clearance from human macrophages by activating LXRalpha. Cholesterol 24-35 nuclear receptor subfamily 1 group H member 3 Homo sapiens 83-91 33788111-5 2021 In patients with total coronary occlusions, LXRbeta mRNA level in epicardial adipose tissue was reduced, and it positively correlated with plasma HDL cholesterol. Cholesterol 150-161 nuclear receptor subfamily 1 group H member 3 Homo sapiens 44-51 34035860-11 2021 Additionally, blocking PPARgamma activity using its inhibitor T0070907 or knocking down LXRalpha expression using short hairpin RNA reversed the effects of Septin 4 overexpression on foam cell formation and cholesterol handling. Cholesterol 207-218 nuclear receptor subfamily 1 group H member 3 Homo sapiens 88-96 33713792-1 2021 The liver x receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) are members of the nuclear hormone receptor superfamily of ligand dependent transcription factors that regulate transcription in response to the direct binding of cholesterol derivatives. Cholesterol 222-233 nuclear receptor subfamily 1 group H member 3 Homo sapiens 22-30 33713792-1 2021 The liver x receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) are members of the nuclear hormone receptor superfamily of ligand dependent transcription factors that regulate transcription in response to the direct binding of cholesterol derivatives. Cholesterol 222-233 nuclear receptor subfamily 1 group H member 3 Homo sapiens 32-37 33713792-1 2021 The liver x receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) are members of the nuclear hormone receptor superfamily of ligand dependent transcription factors that regulate transcription in response to the direct binding of cholesterol derivatives. Cholesterol 222-233 nuclear receptor subfamily 1 group H member 3 Homo sapiens 43-50 33373442-2 2021 The ubiquitously expressed liver X receptor beta (LXRbeta) encoded by the Nr1h2 gene is a critical regulator of cholesterol homeostasis in mammalian cells; however, its cell-intrinsic role in T cell biology remains poorly understood. Cholesterol 112-123 nuclear receptor subfamily 1 group H member 3 Homo sapiens 50-57 33616795-2 2021 Liver X receptor beta (LXRbeta) was considered as a validated target for hyperlipidemia therapy due to its role in regulating cholesterol homeostasis and immunity. Cholesterol 126-137 nuclear receptor subfamily 1 group H member 3 Homo sapiens 23-30 33536383-9 2022 In vitro study showed that miR-320b decreased HDL- and apoA1- mediated cholesterol efflux from macrophages partly by directly targeting ABCG1 and EEPD1 genes and partly via suppressing the LXRalpha-ABCA1/G1 pathway. Cholesterol 71-82 nuclear receptor subfamily 1 group H member 3 Homo sapiens 189-197 33453241-4 2021 The present study investigates whether testosterone exerts anti-atherogenic effects by stimulating cholesterol clearance from macrophages via activation of liver X receptor (LXRalpha), a nuclear master regulator of cellular cholesterol homeostasis, lipid regulation, and inflammation. Cholesterol 224-235 nuclear receptor subfamily 1 group H member 3 Homo sapiens 174-182 33453241-10 2021 SIGNIFICANCE: Testosterone acts via androgen receptor-dependent pathways to stimulate LXRalpha and downstream targets to induce cholesterol clearance in human macrophages. Cholesterol 128-139 nuclear receptor subfamily 1 group H member 3 Homo sapiens 86-94 33420027-9 2021 Furthermore, YTHDF2 inhibits LXRalpha-dependent cholesterol homeostasis in GBM cells. Cholesterol 48-59 nuclear receptor subfamily 1 group H member 3 Homo sapiens 29-37 32501835-6 2020 An increased expression of CH25H and of a number of genes involved in cholesterol metabolism (ABCA1, ABCG1, CYP7B1, LXRalpha, OSBP, PPARgamma, SCARB1) was observed as well; this, was associated with a reduced susceptibility to in vitro HIV-1-infection of PBMCs and MDMs (p<0.01). Cholesterol 70-81 nuclear receptor subfamily 1 group H member 3 Homo sapiens 116-124 33125792-8 2021 Taken together, these findings indicate that IFN-gamma promotes LXR-alpha degradation through a SUMO-ubiquitin-dependent pathway, which may inhibit cholesterol efflux mediated by ABCG1 from macrophages and promote the development of atherosclerosis. Cholesterol 148-159 nuclear receptor subfamily 1 group H member 3 Homo sapiens 64-73 33050595-0 2020 Endoplasmic Reticulum Stress Affects Cholesterol Homeostasis by Inhibiting LXRalpha Expression in Hepatocytes and Macrophages. Cholesterol 37-48 nuclear receptor subfamily 1 group H member 3 Homo sapiens 75-83 33050595-2 2020 Both endoplasmic reticulum (ER) stress and LXRalpha can affect the metabolism of cholesterol. Cholesterol 81-92 nuclear receptor subfamily 1 group H member 3 Homo sapiens 43-51 33050595-3 2020 However, whether ER stress can modulate cholesterol metabolism by LXRalpha in hepatocytes and macrophages remains unclear. Cholesterol 40-51 nuclear receptor subfamily 1 group H member 3 Homo sapiens 66-74 33050595-8 2020 ER stress induced by tunicamycin could clearly be reversed by activating LXRalpha because it promoted cholesterol efflux by enhancing the expression of ABCA1 and ABCG1 in hepatocytes and macrophages, contributing to attenuation of the development of AS. Cholesterol 102-113 nuclear receptor subfamily 1 group H member 3 Homo sapiens 73-81 32598492-10 2020 The results indicate that the potential properties of luteolin in cholesterol metabolism could be explained, at least in part, as being due to upregulated expression of ABCG1, and SRB1 through activation of liver X receptor, LXRalpha signaling pathway in HepG2 cells. Cholesterol 66-77 nuclear receptor subfamily 1 group H member 3 Homo sapiens 225-233 33061802-1 2020 Liver X receptor alpha (LXRalpha) controls a set of key genes involved in cholesterol metabolism. Cholesterol 74-85 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 32276262-2 2020 Here, we propose a novel therapeutic approach through modulating intracellular free cholesterol via the liver X receptor alpha (LXRalpha) in combination with current first line pharmacotherapy, mitotane. Cholesterol 84-95 nuclear receptor subfamily 1 group H member 3 Homo sapiens 128-136 32344083-7 2020 The lipid-lowering mechanism of WABM-A-b is via the activation of the PPARgamma/LXRalpha/ABCA1/ABCG1 cholesterol metabolism pathway. Cholesterol 101-112 nuclear receptor subfamily 1 group H member 3 Homo sapiens 80-88 32276262-7 2020 Inhibition of LXRalpha was confirmed through downregulation of cholesterol efflux pumps ABCA1 and ABCG1, however, combination treatment with mitotane attenuated this effect. Cholesterol 63-74 nuclear receptor subfamily 1 group H member 3 Homo sapiens 14-22 32276262-10 2020 We highlight the importance of LXRalpha mediated cholesterol metabolism in the management of ACC, drawing attention to its role in the therapeutics of mitotane sensitive tumours. Cholesterol 49-60 nuclear receptor subfamily 1 group H member 3 Homo sapiens 31-39 31513924-10 2019 Together, dexamethasone impaired placental cholesterol transport and eventually decreased fetal cholesterol levels, which is related to the down-regulation of LXRalpha mediated by GR/HDAC3/H3K9ac signaling. Cholesterol 43-54 nuclear receptor subfamily 1 group H member 3 Homo sapiens 159-167 32241558-0 2020 Transthyretin Regulated by linc00657/miR-205-5p Promoted Cholesterol Metabolism by Inducing SREBP2-HMGCR and Inhibiting LXRalpha-CYP7A1. Cholesterol 57-68 nuclear receptor subfamily 1 group H member 3 Homo sapiens 120-128 32241558-13 2020 CONCLUSION: Transthyretin regulated cholesterol metabolism mainly through inhibiting LXRalpha-CYP7A1 and promoting SREBP2-HMGCR. Cholesterol 36-47 nuclear receptor subfamily 1 group H member 3 Homo sapiens 85-93 31513924-10 2019 Together, dexamethasone impaired placental cholesterol transport and eventually decreased fetal cholesterol levels, which is related to the down-regulation of LXRalpha mediated by GR/HDAC3/H3K9ac signaling. Cholesterol 96-107 nuclear receptor subfamily 1 group H member 3 Homo sapiens 159-167 31398791-1 2019 Liver X Receptors (LXR) alpha and beta are two members of nuclear receptor superfamily documented as endogenous cholesterol sensors. Cholesterol 112-123 nuclear receptor subfamily 1 group H member 3 Homo sapiens 0-38 31352044-9 2019 Mechanistically, CagA suppresses the transcription of cholesterol efflux transporters by downregulating the expression of transcriptional factors PPARgamma and LXRalpha and thus enhances foam cell formation. Cholesterol 54-65 nuclear receptor subfamily 1 group H member 3 Homo sapiens 160-168 31513924-9 2019 Furthermore, LXRalpha agonist and GR inhibitor reversed respectively dexamethasone-induced the expression inhibitions of cholesterol transporter and LXRalpha, and HDAC3 siRNA reversed the H3K9ac level of LXRalpha promoter and its expression. Cholesterol 121-132 nuclear receptor subfamily 1 group H member 3 Homo sapiens 13-21 31799433-5 2019 We show that lipogenic compounds stabilize active states of LXRalpha and LXRbeta while the anti-atherogenic expression of the cholesterol transporter ABCA1 is associated with the ligand-induced stabilization of LXRalpha helix 3. Cholesterol 126-137 nuclear receptor subfamily 1 group H member 3 Homo sapiens 211-219 30602495-1 2019 The liver X receptors alpha and beta (LXRalpha and LXRbeta) are oxysterol-activated transcription factors that coordinately regulate gene expression that is important for cholesterol and fatty acid metabolism. Cholesterol 171-182 nuclear receptor subfamily 1 group H member 3 Homo sapiens 38-46 30959154-1 2019 Liver X receptors (LXRs) alpha (NR1H3) and beta (NR1H2) are nuclear receptors that have been involved in the regulation of many physiological processes, principally in the control of cholesterol homeostasis, as well as in the control of the cell death and proliferation balance. Cholesterol 183-194 nuclear receptor subfamily 1 group H member 3 Homo sapiens 32-37 30831268-10 2019 Taken together, we provide evidence that both LXRalpha and PXR are transcriptional regulators of PDZK1 supporting the previous notion that the scaffold protein is part of cholesterol homeostasis and drug metabolism. Cholesterol 171-182 nuclear receptor subfamily 1 group H member 3 Homo sapiens 46-54 31313321-8 2019 LXRalpha and ATP-binding cassette transporter A1 (ABCA1) protein levels were significantly (P < 0.05) decreased by 50.35% and 11.60% at 1.00 microM genistein, which indicated that cellular cholesterol efflux was inhibited. Cholesterol 189-200 nuclear receptor subfamily 1 group H member 3 Homo sapiens 0-8 31192592-1 2019 Liver X receptors (LXRalpha/beta), sensors of cholesterol, are involved in regulation of lipid metabolism and are promising drug targets against many diseases, including atherosclerosis, metabolic syndromes, and cancers. Cholesterol 46-57 nuclear receptor subfamily 1 group H member 3 Homo sapiens 19-27 31101336-0 2019 p62/mTOR/LXRalpha pathway inhibits cholesterol efflux mediated by ABCA1 and ABCG1 during autophagy blockage. Cholesterol 35-46 nuclear receptor subfamily 1 group H member 3 Homo sapiens 9-17 31101336-7 2019 Furthermore, the activation of autophagy led to increased expression of ABCA1 and ABCG1, as well as their upstream transcription factor LXRalpha, thereby promoting cholesterol efflux from foam cells. Cholesterol 164-175 nuclear receptor subfamily 1 group H member 3 Homo sapiens 136-144 31101336-9 2019 CONCLUSION: In conclusion, our experiments demonstrated that a p62/mTOR/LXRalpha signaling pathway was involved in cholesterol efflux mediated by ABCA1 and ABCG1 when autophagy blockage occurred. Cholesterol 115-126 nuclear receptor subfamily 1 group H member 3 Homo sapiens 72-80 30964702-3 2019 Two different isoforms, LXRalpha and LXRbeta, have been well characterized in liver, adipocytes, macrophages, and intestinal epithelium among others, but their contribution to cholesterol and fatty acid efflux in the lactating mammary epithelium is poorly understood. Cholesterol 176-187 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 30964702-9 2019 Cumulatively, our findings identify LXRalpha as an important regulator of cholesterol incorporation into the milk through key nodes of de novo lipogenesis, suggesting a potential therapeutic target in women with difficulty initiating lactation. Cholesterol 74-85 nuclear receptor subfamily 1 group H member 3 Homo sapiens 36-44 30602495-1 2019 The liver X receptors alpha and beta (LXRalpha and LXRbeta) are oxysterol-activated transcription factors that coordinately regulate gene expression that is important for cholesterol and fatty acid metabolism. Cholesterol 171-182 nuclear receptor subfamily 1 group H member 3 Homo sapiens 51-58 27401614-2 2018 OBJECTIVES: In this study, we analyzed the prognostic value of the liver X receptor-alpha (LXR-alpha), a nuclear receptor of a family of cholesterol derivatives called oxysterols, in patients with radically resected NSCLC. Cholesterol 137-148 nuclear receptor subfamily 1 group H member 3 Homo sapiens 91-100 30825140-1 2019 Oxidative derivatives of cholesterol such as 22(R)-hydroxycholesterol, 24(S)-hydroxycholesterol, 25-hydroxycholesterol, and (25S),26-hydroxycholesterol are endogenous ligands for the liver X receptors (LXRalpha and LXRbeta). Cholesterol 25-36 nuclear receptor subfamily 1 group H member 3 Homo sapiens 202-210 30154328-4 2018 Interestingly, liver X receptors (LXRalpha/NR1H3 and LXRbeta/NR1H2) have emerged as new actors in prostate physiology, beyond their historical roles of cholesterol sensors. Cholesterol 152-163 nuclear receptor subfamily 1 group H member 3 Homo sapiens 34-42 29181837-2 2018 We previously reported that LXRalpha was aberrantly expressed in human oral squamous cell carcinoma (HOSCC) tissues and cell lines, and that LXR stimulation led to significant reduction of proliferation of HOSCC cells via accelerating cholesterol efflux. Cholesterol 235-246 nuclear receptor subfamily 1 group H member 3 Homo sapiens 28-36 29242172-1 2018 Liver X receptor alpha (LXRalpha) is a nuclear receptor involved in cholesterol homeostasis. Cholesterol 68-79 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 29242172-8 2018 This enhanced reverse cholesterol transport might be related to the up-regulating of ABCA1 and ABCG1 mRNA expression by activating AMPK-LXRalpha signaling in THP-1 cells. Cholesterol 22-33 nuclear receptor subfamily 1 group H member 3 Homo sapiens 136-144 31463370-8 2019 Moreover, these oxysterols led to increased expression of LXRalpha, which is involved in cellular cholesterol efflux, and the ATP-binding cassette transporters, ABCA1 and ABCG1. Cholesterol 98-109 nuclear receptor subfamily 1 group H member 3 Homo sapiens 58-66 30526541-0 2018 Activation of LXRalpha/beta by cholesterol in malignant ascites promotes chemoresistance in ovarian cancer. Cholesterol 31-42 nuclear receptor subfamily 1 group H member 3 Homo sapiens 14-22 30526541-7 2018 RESULTS: Here we show that cholesterol is elevated in malignant ascites and modulates the sensitivity of ovarian cancer cells to CDDP and PAC by upregulating the expression of drug efflux pump proteins, ABCG2 and MDR1, together with upregulation of LXRalpha/beta, the cholesterol receptor. Cholesterol 27-38 nuclear receptor subfamily 1 group H member 3 Homo sapiens 249-257 30526541-8 2018 Transfection of LXRalpha/beta siRNA inhibited cholesterol-induced chemoresistance and upregulation of MDR1. Cholesterol 46-57 nuclear receptor subfamily 1 group H member 3 Homo sapiens 16-24 30526541-10 2018 Cholesterol depletion by methyl beta cyclodextrin (MbetaCD) inhibited malignant ascites-induced chemoresistance to CDDP and upregulation of MDR1 and LXRalpha/beta. Cholesterol 0-11 nuclear receptor subfamily 1 group H member 3 Homo sapiens 149-157 30526541-12 2018 CONCLUSIONS: High cholesterol in malignant ascites contributes to poor prognosis in ovarian cancer patients, partly by contributing to multidrug resistance through upregulation of MDR1 via activation of LXRalpha/beta. Cholesterol 18-29 nuclear receptor subfamily 1 group H member 3 Homo sapiens 203-211 30351048-12 2018 OA also enhanced LXRalpha-mediated induction of reverse cholesterol transport (RCT)-related gene, ATP-binding cassette transporter (ABC) A1, and ABCG1 expression in intestinal cells. Cholesterol 56-67 nuclear receptor subfamily 1 group H member 3 Homo sapiens 17-25 29577901-1 2018 The Liver X Receptor alpha (LXRalpha) belongs to the nuclear receptor superfamily and plays an essential role in regulating cholesterol, lipid and glucose metabolism and inflammatory responses. Cholesterol 124-135 nuclear receptor subfamily 1 group H member 3 Homo sapiens 28-36 29535632-7 2018 It was found that 6-GN regulated cholesterol metabolism via up-regulation of LDLR through activation of SREBP2 as well as up-regulation of cholesterol efflux-related genes LXRalpha and ABCA1. Cholesterol 139-150 nuclear receptor subfamily 1 group H member 3 Homo sapiens 172-180 29292466-0 2018 Quercetin induces the selective uptake of HDL-cholesterol via promoting SR-BI expression and the activation of the PPARgamma/LXRalpha pathway. Cholesterol 46-57 nuclear receptor subfamily 1 group H member 3 Homo sapiens 125-133 28781617-9 2017 In conclusion, IL-32alpha enhances lipid accumulation and inhibits cholesterol efflux from ox-LDL-exposed THP-1 macrophages by regulating the PPARgamma-LXRalpha-ABCA1 pathway. Cholesterol 67-78 nuclear receptor subfamily 1 group H member 3 Homo sapiens 152-160 28499814-0 2017 Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRalpha in HepG2 cells. Cholesterol 9-20 nuclear receptor subfamily 1 group H member 3 Homo sapiens 128-136 28673011-9 2017 In addition, silencing of LXRalpha or PPARgamma via small interfering RNA transfection significantly reversed the Trib1-induced cholesterol efflux. Cholesterol 128-139 nuclear receptor subfamily 1 group H member 3 Homo sapiens 26-34 28356389-5 2017 Mechanistically, c-Fos decreases expression and activity of the nuclear receptor LXRalpha, leading to increased hepatic cholesterol and accumulation of toxic oxysterols and bile acids. Cholesterol 120-131 nuclear receptor subfamily 1 group H member 3 Homo sapiens 81-89 28082258-1 2017 OBJECTIVE: The sterol-responsive nuclear receptors, liver X receptors alpha (LXRalpha, NR1H3) and beta (LXRbeta, NR1H2), are key determinants of cellular cholesterol homeostasis. Cholesterol 154-165 nuclear receptor subfamily 1 group H member 3 Homo sapiens 77-85 28082258-1 2017 OBJECTIVE: The sterol-responsive nuclear receptors, liver X receptors alpha (LXRalpha, NR1H3) and beta (LXRbeta, NR1H2), are key determinants of cellular cholesterol homeostasis. Cholesterol 154-165 nuclear receptor subfamily 1 group H member 3 Homo sapiens 87-92 28096801-9 2016 Finally, PLD activated LXRalpha-ABCA1-dependent cholesterol efflux. Cholesterol 48-59 nuclear receptor subfamily 1 group H member 3 Homo sapiens 23-31 27629819-0 2017 Simvastatin promotes NPC1-mediated free cholesterol efflux from lysosomes through CYP7A1/LXRalpha signalling pathway in oxLDL-loaded macrophages. Cholesterol 40-51 nuclear receptor subfamily 1 group H member 3 Homo sapiens 89-97 28989932-1 2017 Liver X receptor alpha (LXRalpha) is crucial for the maintenance of lipid and cholesterol homeostasis. Cholesterol 78-89 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 27735019-12 2016 CONCLUSIONS: Quercetin could increase ABCA1 expression and cholesterol efflux through LXRalpha pathway to eventually promote RCT in the THP-1 macrophage. Cholesterol 59-70 nuclear receptor subfamily 1 group H member 3 Homo sapiens 86-94 28105139-8 2016 Furthermore, baicalin increased the expression of PPAR-gamma and LXRalpha, and the application of specific agonists and inhibitors of PPAR-gamma and LXRalpha changed the expression of SR-BI, as well as cholesterol efflux. Cholesterol 202-213 nuclear receptor subfamily 1 group H member 3 Homo sapiens 149-157 28105139-9 2016 It may be concluded that baicalin induced cholesterol efflux from THP-1 macrophages via the PPAR-gamma/LXRalpha/SR-BI pathway. Cholesterol 42-53 nuclear receptor subfamily 1 group H member 3 Homo sapiens 103-111 27592060-11 2016 Additionally, the mRNA and protein expression of cholesterol synthesis-related factors, such as SREBP-1, HMGCR, were down-regulated (p<0.05), while the mRNA and protein expression of cholesterol transport-related factors (LXR-alpha, ABCA1) were up-regulated (p<0.05). Cholesterol 49-60 nuclear receptor subfamily 1 group H member 3 Homo sapiens 225-234 26725543-6 2016 Moreover, immunohistochemical evaluation revealed that LXRalpha and ABCA1 immunoreactivities (IR) were reduced in the AAA media compared to the normal and ATH media layers and that they were also reduced in the intima layer of AAA and ATH tissues, whereas ApoAI-IR was increased in the AAA and ATH aortic walls compared to normal pointing to possible deregulation of the cholesterol efflux mechanism in AAA. Cholesterol 371-382 nuclear receptor subfamily 1 group H member 3 Homo sapiens 55-63 26692490-11 2016 In conclusion, our data indicate that HNF-4alpha may have a wider role in cell and plasma cholesterol homeostasis by controlling the expression of LXRalpha in hepatic cells. Cholesterol 90-101 nuclear receptor subfamily 1 group H member 3 Homo sapiens 147-155 25496323-6 2015 Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux. Cholesterol 114-125 nuclear receptor subfamily 1 group H member 3 Homo sapiens 58-67 26722214-8 2016 In conclusion, excess NO may activate calpain via TRPV1-Ca(2+) signaling and promote the recognition of calpain in the PEST motif of LXRalpha, thereby leading to degradation of LXRalpha and, ultimately, downregulated ABCA1 expression and impaired ABCA1-dependent cholesterol efflux in macrophages. Cholesterol 263-274 nuclear receptor subfamily 1 group H member 3 Homo sapiens 133-141 26603933-6 2015 We hypothesize that GLP-1 mimetics and/or DPP-4 inhibitors modulate ABCA1/ABCG1 expression in adipocytes through an LXR-alpha mediated process and thus affecting cholesterol homeostasis. Cholesterol 162-173 nuclear receptor subfamily 1 group H member 3 Homo sapiens 116-125 26603933-8 2015 Gene and protein expression of ABCA1, ABCG1 and LXR-alpha were determined and correlated with cholesterol efflux. Cholesterol 94-105 nuclear receptor subfamily 1 group H member 3 Homo sapiens 48-57 26475038-12 2015 Moreover, SSa activated LXRalpha-ABCA1 signaling pathway, which could induce cholesterol efflux from lipid rafts. Cholesterol 77-88 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 26475038-14 2015 In conclusion, the effects of SSa is associated with activating LXRalpha-ABCA1 signaling pathway which results in disrupting lipid rafts by depleting cholesterol and reducing translocation of TLR4 to lipid rafts and oligomerization of TLR4, thereby attenuating LPS mediated oxidative and inflammatory responses. Cholesterol 150-161 nuclear receptor subfamily 1 group H member 3 Homo sapiens 64-72 26264562-7 2015 The inhibitory effects of lycopene on cholesterol absorption and NPC1L1 expression could be prevented by blockade of the LXRalpha pathway. Cholesterol 38-49 nuclear receptor subfamily 1 group H member 3 Homo sapiens 121-129 25496323-6 2015 Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux. Cholesterol 232-243 nuclear receptor subfamily 1 group H member 3 Homo sapiens 58-67 25496323-6 2015 Small interfering RNA-mediated silencing of PPAR-gamma or LXR-alpha dose dependently reversed alpinetin-increased cholesterol efflux in THP-1 macrophages, indicating the involvement of PPAR-gamma and LXR-alpha in alpinetin-promoted cholesterol efflux. Cholesterol 114-125 nuclear receptor subfamily 1 group H member 3 Homo sapiens 200-209 25496323-8 2015 Taken together, our results reveal that alpinetin exhibits positive effects on cholesterol efflux and inhibits ox-LDL-induced lipid accumulation, which might be through PPAR-gamma/LXR-alpha/ABCA1/ABCG1 pathway. Cholesterol 79-90 nuclear receptor subfamily 1 group H member 3 Homo sapiens 180-189 25956064-0 2015 Salvianolic acid B accelerated ABCA1-dependent cholesterol efflux by targeting PPAR-gamma and LXRalpha. Cholesterol 47-58 nuclear receptor subfamily 1 group H member 3 Homo sapiens 94-102 26102194-0 2015 Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells. Cholesterol 18-29 nuclear receptor subfamily 1 group H member 3 Homo sapiens 89-97 26102194-6 2015 Thus, curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through activating AMPK-SIRT1-LXRalpha signaling in THP-1 macrophage-derived foam cells. Cholesterol 24-35 nuclear receptor subfamily 1 group H member 3 Homo sapiens 106-114 26551724-1 2015 The liver X receptors (LXRs), LXRalpha and LXRbeta, are transcription factors with well-established roles in the regulation of lipid metabolism and cholesterol homeostasis. Cholesterol 148-159 nuclear receptor subfamily 1 group H member 3 Homo sapiens 30-38 25779847-12 2015 In conclusion, the data demonstrated that treatment with Ang-(1-7) promoted cholesterol efflux in Ang II-treated THP-1 macrophages, partly through inactivation of p38 and JNK signaling and by inducing the expression of PPARgamma and LXRalpha. Cholesterol 76-87 nuclear receptor subfamily 1 group H member 3 Homo sapiens 233-241 25600616-2 2015 Liver X receptor (LXRalpha) and peroxisome proliferator-activated receptor-gamma (PPARgamma) operate as cholesterol sensors, which may protect from cholesterol overload by stimulating cholesterol efflux from cells to high-density lipoprotein through ABCA1, ABCG1, and SR-B1. Cholesterol 104-115 nuclear receptor subfamily 1 group H member 3 Homo sapiens 18-26 25600616-2 2015 Liver X receptor (LXRalpha) and peroxisome proliferator-activated receptor-gamma (PPARgamma) operate as cholesterol sensors, which may protect from cholesterol overload by stimulating cholesterol efflux from cells to high-density lipoprotein through ABCA1, ABCG1, and SR-B1. Cholesterol 148-159 nuclear receptor subfamily 1 group H member 3 Homo sapiens 18-26 25600616-2 2015 Liver X receptor (LXRalpha) and peroxisome proliferator-activated receptor-gamma (PPARgamma) operate as cholesterol sensors, which may protect from cholesterol overload by stimulating cholesterol efflux from cells to high-density lipoprotein through ABCA1, ABCG1, and SR-B1. Cholesterol 148-159 nuclear receptor subfamily 1 group H member 3 Homo sapiens 18-26 26015858-5 2015 There is clear evidence that targeting either of these proteins enhances removal of cholesterol via LXRalpha-dependent induction of ATP binding cassette transporters (ABCA1, ABCG1) and limits the production of inflammatory cytokines; interventions which influence mitochondrial structure and bioenergetics also impact on removal of cholesterol from macrophages. Cholesterol 84-95 nuclear receptor subfamily 1 group H member 3 Homo sapiens 100-108 26015858-5 2015 There is clear evidence that targeting either of these proteins enhances removal of cholesterol via LXRalpha-dependent induction of ATP binding cassette transporters (ABCA1, ABCG1) and limits the production of inflammatory cytokines; interventions which influence mitochondrial structure and bioenergetics also impact on removal of cholesterol from macrophages. Cholesterol 332-343 nuclear receptor subfamily 1 group H member 3 Homo sapiens 100-108 26113985-5 2015 TRPV1-mediated induction of LXRalpha in foam cells promotes cholesterol export, antagonising plaque formation. Cholesterol 60-71 nuclear receptor subfamily 1 group H member 3 Homo sapiens 28-36 25334019-10 2015 These findings suggest that FGF21 may have a protective effect against atherosclerosis by enhancing cholesterol efflux through the induction of LXRalpha-dependent ABCA1 and ABCG1 expression. Cholesterol 100-111 nuclear receptor subfamily 1 group H member 3 Homo sapiens 144-152 26261553-6 2015 However, after short interfering RNA of LXRalpha, the effects of LXA4 on ABCA1 expression and cholesterol metabolism were significantly abolished. Cholesterol 94-105 nuclear receptor subfamily 1 group H member 3 Homo sapiens 40-48 26261553-7 2015 These results provide evidence that LXA4 increases ABCA1 expression and promotes cholesterol efflux through LXRalpha pathway in THP-1 macrophage-derived foam cells. Cholesterol 81-92 nuclear receptor subfamily 1 group H member 3 Homo sapiens 108-116 25755733-2 2015 Liver X receptor alpha (LXRalpha) can stimulate cholesterol efflux through ABCA1. Cholesterol 48-59 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 26670369-10 2015 PR-induced increases in LXRa mRNA levels may be involved in attenuation of NPC1L1 expression, subsequently decreasing intestinal cholesterol absorption. Cholesterol 129-140 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-28 25225013-1 2014 Adenosine triphosphate-binding cassette transporter A1 (ABCA1) and ABCG1 play crucial roles in reverse cholesterol transport, and have anti-atherosclerosis effects, and liver X receptor alpha (LXRalpha) can stimulate cholesterol efflux through these transporters. Cholesterol 103-114 nuclear receptor subfamily 1 group H member 3 Homo sapiens 193-201 25450668-1 2014 Liver X receptor alpha (LXRalpha) plays an important role in the cholesterol metabolism process, and LXRalpha activation can reduce atherosclerosis. Cholesterol 65-76 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 25225013-1 2014 Adenosine triphosphate-binding cassette transporter A1 (ABCA1) and ABCG1 play crucial roles in reverse cholesterol transport, and have anti-atherosclerosis effects, and liver X receptor alpha (LXRalpha) can stimulate cholesterol efflux through these transporters. Cholesterol 217-228 nuclear receptor subfamily 1 group H member 3 Homo sapiens 193-201 24947527-2 2014 The liver X receptors (LXRs; LXRalpha and LXRbeta) regulate RCT by controlling the efflux of cholesterol from macrophages to HDL and the excretion, catabolism, and absorption of cholesterol in the liver and intestine. Cholesterol 178-189 nuclear receptor subfamily 1 group H member 3 Homo sapiens 29-37 25035925-5 2014 (ii) The IL-10-mediated effects on cholesterol efflux were accompanied by an increased IL-10-mediated expression of the ATP-binding cassette transporters ABCA1 and ABCG1, that was further enhanced when the cells were co-activated with the liver X receptor (LXR)alpha agonist (22R)-hydroxycholesterol. Cholesterol 35-46 nuclear receptor subfamily 1 group H member 3 Homo sapiens 257-266 25035925-8 2014 This study suggests that the anti-atherogenic properties of IL-10 may include enhancing effects on cholesterol efflux mechanism that involves cross-talk with LXRalpha activation. Cholesterol 99-110 nuclear receptor subfamily 1 group H member 3 Homo sapiens 158-166 24947527-2 2014 The liver X receptors (LXRs; LXRalpha and LXRbeta) regulate RCT by controlling the efflux of cholesterol from macrophages to HDL and the excretion, catabolism, and absorption of cholesterol in the liver and intestine. Cholesterol 93-104 nuclear receptor subfamily 1 group H member 3 Homo sapiens 29-37 24735204-0 2014 FGF21 increases cholesterol efflux by upregulating ABCA1 through the ERK1/2-PPARgamma-LXRalpha pathway in THP1 macrophage-derived foam cells. Cholesterol 16-27 nuclear receptor subfamily 1 group H member 3 Homo sapiens 86-94 24735204-9 2014 In addition, inhibition of ERK1/2 or PPARgamma, or knockdown of LXRalpha attenuated FGF21-mediated promotion of ABCA1 expression and cholesterol efflux. Cholesterol 133-144 nuclear receptor subfamily 1 group H member 3 Homo sapiens 64-72 24735204-10 2014 These results demonstrate that FGF21 can promote cholesterol efflux by upregulating ABCA1 through the ERK1/2-PPARgamma-LXRalpha pathway in THP1 macrophage-derived foam cells. Cholesterol 49-60 nuclear receptor subfamily 1 group H member 3 Homo sapiens 119-127 24996838-0 2014 Cholesterol efflux is LXRalpha isoform-dependent in human macrophages. Cholesterol 0-11 nuclear receptor subfamily 1 group H member 3 Homo sapiens 22-30 24996838-4 2014 RESULTS: Here we show that LXRalpha rather than LXRbeta sustains baseline cholesterol efflux in human blood-derived macrophages. Cholesterol 74-85 nuclear receptor subfamily 1 group H member 3 Homo sapiens 27-35 24996838-6 2014 The siRNA- mediated silencing of LXRalpha, but not LXRbeta significantly reduced the protein levels of ABCA1,ABCG1, and SR-BI as wellas HDL- and ApoA1-mediated cholesterol in human macrophages. Cholesterol 160-171 nuclear receptor subfamily 1 group H member 3 Homo sapiens 33-41 24996838-7 2014 CONCLUSIONS: These findings imply that LXRalpha- rather than LXRbeta- specific agonists may promote reverse cholesterol transport in humans. Cholesterol 108-119 nuclear receptor subfamily 1 group H member 3 Homo sapiens 39-47 24751522-0 2014 miR-613 regulates cholesterol efflux by targeting LXRalpha and ABCA1 in PPARgamma activated THP-1 macrophages. Cholesterol 18-29 nuclear receptor subfamily 1 group H member 3 Homo sapiens 50-58 24751522-5 2014 Furthermore, downregulation of LXRalpha and ABCA1 by miR-613 inhibited cholesterol efflux from PPARgamma activated THP-1 macrophages. Cholesterol 71-82 nuclear receptor subfamily 1 group H member 3 Homo sapiens 31-39 24704452-4 2014 Several lines of evidence have indicated that the activation of either peroxisome proliferator-activated receptor gamma (PPARgamma) or liver X receptor alpha (LXRalpha) relates to cholesterol efflux. Cholesterol 180-191 nuclear receptor subfamily 1 group H member 3 Homo sapiens 159-167 24603323-1 2014 Liver X receptors (LXRalpha and LXRbeta) are key transcription factors in cholesterol metabolism that regulate cholesterol biosynthesis/efflux and bile acid metabolism/excretion in the liver and numerous organs. Cholesterol 74-85 nuclear receptor subfamily 1 group H member 3 Homo sapiens 19-27 24603323-1 2014 Liver X receptors (LXRalpha and LXRbeta) are key transcription factors in cholesterol metabolism that regulate cholesterol biosynthesis/efflux and bile acid metabolism/excretion in the liver and numerous organs. Cholesterol 111-122 nuclear receptor subfamily 1 group H member 3 Homo sapiens 19-27 24334278-1 2014 Liver X receptor alpha (LXRalpha) plays an important role in reverse cholesterol transport (RCT), and activation of LXRalpha could reduce atherosclerosis. Cholesterol 69-80 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 24372550-2 2014 The closely related liver X receptors (LXRalpha/beta), oestrogen receptors (ERalpha/beta) and glucocorticoid receptor (GR) regulate many endogenous processes such as lipid/cholesterol homeostasis, cellular differentiation and inflammation. Cholesterol 172-183 nuclear receptor subfamily 1 group H member 3 Homo sapiens 39-47 24704452-12 2014 In conclusion, the present findings indicate that the anti-lipid deposition action of 22(R)-hydroxycholesterol combined with pioglitazone involves the activation of the PPARgamma-LXRalpha-ABCA1 pathway, increased ABCA1 expression and the efflux of cholesterol from GBECs. Cholesterol 99-110 nuclear receptor subfamily 1 group H member 3 Homo sapiens 179-187 25011264-7 2014 CONCLUSION: Ligustrazine can promote the reverse cholesterol transport by increasing the gene expressions of PPARgamma, LXRalpha and ABCA1. Cholesterol 49-60 nuclear receptor subfamily 1 group H member 3 Homo sapiens 120-128 23686114-2 2013 For instance, the accumulation of excess cholesterol by macrophages initiates a genetic response mediated by the liver X receptors (LXRs)-alpha (NR1H3) and LXRbeta (NR1H2), which facilitates the transport of cholesterol out of cells to high-density lipoprotein particles. Cholesterol 41-52 nuclear receptor subfamily 1 group H member 3 Homo sapiens 145-150 23812592-5 2013 SiRNA-mediated silencing of LXRalpha revealed that LXRalpha was involved in these increases and the enhanced cholesterol efflux. Cholesterol 109-120 nuclear receptor subfamily 1 group H member 3 Homo sapiens 28-36 23812592-5 2013 SiRNA-mediated silencing of LXRalpha revealed that LXRalpha was involved in these increases and the enhanced cholesterol efflux. Cholesterol 109-120 nuclear receptor subfamily 1 group H member 3 Homo sapiens 51-59 23812592-6 2013 CONCLUSION: Nifedipine may protect against atherosclerosis partly by promoting macrophage cholesterol efflux through the stimulation of LXRalpha-dependent expression of ABCA1, ABCG1, and SR-BI. Cholesterol 90-101 nuclear receptor subfamily 1 group H member 3 Homo sapiens 136-144 23732298-3 2013 In this study, we have investigated a possible involvement of liver X receptor alpha (LXRalpha), a critical regulator of cholesterol homeostasis, in the hepatic CYP3A4 expression since several recent reports suggest the involvement of CYP3A enzymes in the cholesterol metabolism in humans and mice. Cholesterol 121-132 nuclear receptor subfamily 1 group H member 3 Homo sapiens 86-94 23732298-3 2013 In this study, we have investigated a possible involvement of liver X receptor alpha (LXRalpha), a critical regulator of cholesterol homeostasis, in the hepatic CYP3A4 expression since several recent reports suggest the involvement of CYP3A enzymes in the cholesterol metabolism in humans and mice. Cholesterol 256-267 nuclear receptor subfamily 1 group H member 3 Homo sapiens 86-94 23313547-6 2013 Our aim was therefore to determine the contribution of LXRalpha and LXRbeta to the control of cholesterol efflux in human macrophages. Cholesterol 94-105 nuclear receptor subfamily 1 group H member 3 Homo sapiens 55-63 23313547-10 2013 In contrast, LXRalpha silencing reduced the response of these LXR-target genes to LXR agonist and inhibited cholesterol efflux to ApoA-I, HDL2 or to endogenous ApoE. Cholesterol 108-119 nuclear receptor subfamily 1 group H member 3 Homo sapiens 13-21 23686114-2 2013 For instance, the accumulation of excess cholesterol by macrophages initiates a genetic response mediated by the liver X receptors (LXRs)-alpha (NR1H3) and LXRbeta (NR1H2), which facilitates the transport of cholesterol out of cells to high-density lipoprotein particles. Cholesterol 208-219 nuclear receptor subfamily 1 group H member 3 Homo sapiens 145-150 23686114-6 2013 The gene-selective response to cholesterol loading occurs, even in the presence of LXRalpha binding to the promoter of the gene encoding the sterol regulatory element-binding protein-1c, the master transcriptional regulator of fatty acid synthesis. Cholesterol 31-42 nuclear receptor subfamily 1 group H member 3 Homo sapiens 83-91 23658787-4 2013 Whilst direct PPARgamma-agonism promoted cholesterol efflux from THP-1 derived foam cells by 37.7+-3.1% (P<0.01) and stimulated transcription of LXRalpha by 87.9+-9.5% (P<0.001) and ABCG1 by 101.2+-15.5% (P<0.01), NA showed no effect in foam cells on either cholesterol efflux or key RCT genes transcription. Cholesterol 267-278 nuclear receptor subfamily 1 group H member 3 Homo sapiens 148-156 23451202-1 2013 OBJECTIVE: The liver X receptor alpha (LXRalpha) is a ligand-dependent nuclear receptor and the major regulator of reverse cholesterol transport in macrophages. Cholesterol 123-134 nuclear receptor subfamily 1 group H member 3 Homo sapiens 39-47 23393188-7 2013 These observations identified highly integrated LXRalpha ligand-dependent transcriptional networks, including the APOE/C1/C4/C2-gene cluster, which contribute to the reversal of cholesterol efflux and the dampening of inflammation processes in foam cells to prevent atherogenesis. Cholesterol 178-189 nuclear receptor subfamily 1 group H member 3 Homo sapiens 48-56 22137263-5 2012 Lycopene (10 muM) in the presence of a specific antagonist of PPARgamma (GW9662) or of LXRalpha (GGPP) restored the proliferation of DU145 cells and significantly suppressed lycopene-induced protein and mRNA expression of PPARgamma and LXRalpha and cholesterol efflux. Cholesterol 249-260 nuclear receptor subfamily 1 group H member 3 Homo sapiens 87-95 22723445-1 2012 OBJECTIVE: Liver X receptors (LXRalpha, LXRbeta) are master regulators of cholesterol homeostasis. Cholesterol 74-85 nuclear receptor subfamily 1 group H member 3 Homo sapiens 30-38 22569763-7 2012 Serum proportions of liver X receptor alpha (LXRalpha) ligand oxysterols (ratios to cholesterol) were significantly elevated in the NAFLD patients compared to the controls. Cholesterol 84-95 nuclear receptor subfamily 1 group H member 3 Homo sapiens 45-53 22429094-8 2012 These results provide evidence that 1 promotes ApoA-I-mediated cholesterol efflux from macrophages by increasing ABCA1 expression through the activation of LXRalpha and PPARgamma. Cholesterol 63-74 nuclear receptor subfamily 1 group H member 3 Homo sapiens 156-164 22535758-8 2012 27-Hydroxycholesterol (27OH-C) activated liver-X-receptor alpha (LXRalpha) (P < 0.01) and stimulated ATP-binding cassette transporter (ABC) A1 expression (P < 0.001) and basolateral systemic cholesterol secretion from enterocytes (P < 0.05). Cholesterol 10-21 nuclear receptor subfamily 1 group H member 3 Homo sapiens 65-73 22535758-12 2012 Due to constitutive apical expression of ABCG5/G8 and LXRalpha-enhanced basolateral expression of ABCA1 in enterocytes, interference of phytosterols with the generation of the dominating LXRalpha-agonist 27OH-C blocks the self-priming component of cholesterol absorption. Cholesterol 248-259 nuclear receptor subfamily 1 group H member 3 Homo sapiens 54-62 22535758-13 2012 This local LXRalpha antagonism of dietary phytosterols contributes to sterol selectivity and reduces fractional cholesterol absorption and preloading of nascent HDL with dietary cholesterol. Cholesterol 112-123 nuclear receptor subfamily 1 group H member 3 Homo sapiens 11-19 22535758-13 2012 This local LXRalpha antagonism of dietary phytosterols contributes to sterol selectivity and reduces fractional cholesterol absorption and preloading of nascent HDL with dietary cholesterol. Cholesterol 178-189 nuclear receptor subfamily 1 group H member 3 Homo sapiens 11-19 22707265-2 2012 We examined whether taurine could activate liver X receptor-alpha (LXR-alpha), a critical transcription factor in the regulation of reverse cholesterol transport in macrophages. Cholesterol 140-151 nuclear receptor subfamily 1 group H member 3 Homo sapiens 67-76 22098164-9 2012 High-fat diet in mice and low-density lipoprotein (LDL) loading in HepG2 cells increased bile acid synthesis and cholesterol efflux, enhanced the mRNA and protein expression of liver X receptor alpha (LXRalpha), peroxisome proliferator-activated receptors (PPARalpha, gamma), cholesterol 7alpha-hydroxylase (CYP7A1) and ATP-binding cassette transporter A1 (ABCA1). Cholesterol 113-124 nuclear receptor subfamily 1 group H member 3 Homo sapiens 201-209 23118965-10 2012 CONCLUSIONS/SIGNIFICANCE: We evidenced for the first time that phthalate increases the levels of mRNA for LXRalpha, and SREBP members potentially deregulating lipids/cholesterol synthesis in human fetal gonads. Cholesterol 166-177 nuclear receptor subfamily 1 group H member 3 Homo sapiens 106-114 22052915-11 2012 Expression of LXR-beta in turn led to induction of other genes central to cholesterol efflux, such as LXR-alpha and ABCA1. Cholesterol 74-85 nuclear receptor subfamily 1 group H member 3 Homo sapiens 102-111 21356276-1 2011 The liver X receptors (LXR-alpha and -beta) are nuclear oxysterol receptors that play pivotal roles in regulating the expression of genes involved in cholesterol transport and metabolism. Cholesterol 150-161 nuclear receptor subfamily 1 group H member 3 Homo sapiens 23-32 23185273-1 2012 BACKGROUND: Liver X receptor (LXR) alpha and LXR beta (NR1H3 and NR1H2) are oxysterol-activated nuclear receptors involved in the control of major metabolic pathways such as cholesterol homeostasis, lipogenesis, inflammation and innate immunity. Cholesterol 174-185 nuclear receptor subfamily 1 group H member 3 Homo sapiens 55-60 21489984-3 2011 However, SREBP-2 is in balance with the liver X receptor (LXR; NR1H2/NR1H3), a transcription factor that prevents cholesterol accumulation. Cholesterol 114-125 nuclear receptor subfamily 1 group H member 3 Homo sapiens 69-74 21862012-0 2011 Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via PPARgamma/LXRalpha pathway: findings from in vitro and ex vivo studies. Cholesterol 22-33 nuclear receptor subfamily 1 group H member 3 Homo sapiens 110-118 21562465-1 2011 BACKGROUND/AIMS: Liver X receptor-alpha (LXRA) is a nuclear receptor that regulates genes important in cholesterol homeostasis and inflammation. Cholesterol 103-114 nuclear receptor subfamily 1 group H member 3 Homo sapiens 41-45 21316679-1 2011 OBJECTIVE: Genetic variability in the NR1H3 gene (encoding LXRalpha) and in several of its target genes is associated with serum HDL-cholesterol (HDL-C) concentrations. Cholesterol 133-144 nuclear receptor subfamily 1 group H member 3 Homo sapiens 38-43 21316679-1 2011 OBJECTIVE: Genetic variability in the NR1H3 gene (encoding LXRalpha) and in several of its target genes is associated with serum HDL-cholesterol (HDL-C) concentrations. Cholesterol 133-144 nuclear receptor subfamily 1 group H member 3 Homo sapiens 59-67 21333456-1 2011 Liver X receptors (LXRalpha and LXRbeta) are members of the nuclear receptor family and are important regulators of cholesterol, fatty acid, and glucose homeostasis. Cholesterol 116-127 nuclear receptor subfamily 1 group H member 3 Homo sapiens 19-27 21350215-7 2011 Interleukin (IL)-4-polarized CD68(+)MR(+) macrophages display a reduced capacity to handle and efflux cellular cholesterol because of low expression levels of the nuclear receptor liver x receptor (LXR)alpha and its target genes, ABCA1 and apolipoprotein E, attributable to the high 15-lipoxygenase activity in CD68(+)MR(+) macrophages. Cholesterol 111-122 nuclear receptor subfamily 1 group H member 3 Homo sapiens 198-207 20927647-4 2010 Further based upon these results, it was proposed that Abeta-induced heme oxygenase-1 can ensure cholesterol-oxidation to provide endogenous ligands for the sustained activation of neuronal LXR-alpha dependent epigenomic-pathway leading to neuronal death observed in Alzheimer"s disease. Cholesterol 97-108 nuclear receptor subfamily 1 group H member 3 Homo sapiens 190-199 21125317-1 2011 There exists a general recognition of the fact that LXR-alpha, being a member of the nuclear receptor family, plays a crucial role in the biological process that connects inflammation, cholesterol homeostasis, and cellular decisions. Cholesterol 185-196 nuclear receptor subfamily 1 group H member 3 Homo sapiens 52-61 20945144-1 2010 The oxysterol nuclear receptors, LXRalpha (liver X receptor alpha; NR1H3) and LXRbeta (NR1H2), coordinately regulate the expression of genes involved in lipid metabolism, anti-inflammation, and cholesterol transport. Cholesterol 194-205 nuclear receptor subfamily 1 group H member 3 Homo sapiens 33-41 20837678-1 2010 The liver X receptors (LXRalpha and LXRbeta) are members of the nuclear receptor superfamily that function as key transcriptional regulators of a number of biological processes, including cholesterol homeostasis, lipid metabolism, and keratinocyte differentiation. Cholesterol 188-199 nuclear receptor subfamily 1 group H member 3 Homo sapiens 23-31 20871621-9 2010 CONCLUSION: Ibrolipim increased ABCA1 and ABCG1 expression and promoted cholesterol efflux, which was mediated by the LXRalpha signaling pathway. Cholesterol 72-83 nuclear receptor subfamily 1 group H member 3 Homo sapiens 118-126 20494359-1 2010 Liver X receptors (LXRs), LXRalpha and LXRbeta, are members of the nuclear receptor superfamily and regulate the expression of genes involved in the regulation of cholesterol and fatty acid metabolism. Cholesterol 163-174 nuclear receptor subfamily 1 group H member 3 Homo sapiens 26-34 20945144-1 2010 The oxysterol nuclear receptors, LXRalpha (liver X receptor alpha; NR1H3) and LXRbeta (NR1H2), coordinately regulate the expression of genes involved in lipid metabolism, anti-inflammation, and cholesterol transport. Cholesterol 194-205 nuclear receptor subfamily 1 group H member 3 Homo sapiens 67-72 20570635-6 2010 In contrast, treatment with endogenous or synthetic LXR alpha/beta ligands such as T0901317 increased ABCA1 and ABCG1 expression and enhanced cholesterol efflux to apoA-I and HDL, respectively, while treatment with pharmacological PPAR-alpha or -gamma ligands was without effect. Cholesterol 142-153 nuclear receptor subfamily 1 group H member 3 Homo sapiens 52-61 20597026-1 2010 The liver X receptors LXRalpha and LXRbeta regulate the expression of genes promoting cellular cholesterol efflux and the formation of HDL particles, and are atheroprotective. Cholesterol 95-106 nuclear receptor subfamily 1 group H member 3 Homo sapiens 22-30 20506155-0 2010 Anti-atherogenic effect of berberine on LXRalpha-ABCA1-dependent cholesterol efflux in macrophages. Cholesterol 65-76 nuclear receptor subfamily 1 group H member 3 Homo sapiens 40-48 20419060-0 2010 PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1. Cholesterol 59-70 nuclear receptor subfamily 1 group H member 3 Homo sapiens 15-23 21160732-6 2010 This blood cellular mutated LXR-alpha gene expression correlated specifically with the extent of coronary occlusion and hence need is felt to devise new synthetic ligands that could restore the function of this mutated LXR-alpha protein in order to modulate genes involved in reverse cholesterol transport and suppression of the inflammatory response leading to the effective treatment of CHD. Cholesterol 284-295 nuclear receptor subfamily 1 group H member 3 Homo sapiens 28-37 21160732-6 2010 This blood cellular mutated LXR-alpha gene expression correlated specifically with the extent of coronary occlusion and hence need is felt to devise new synthetic ligands that could restore the function of this mutated LXR-alpha protein in order to modulate genes involved in reverse cholesterol transport and suppression of the inflammatory response leading to the effective treatment of CHD. Cholesterol 284-295 nuclear receptor subfamily 1 group H member 3 Homo sapiens 219-228 20060389-2 2010 The sterol-responsive transcription factors liver X receptors (LXRalpha and LXRbeta) help maintain cholesterol homeostasis, not only through promotion of cholesterol efflux from peripheral tissues but also through suppression of de novo synthesis and exogenous cholesterol uptake. Cholesterol 99-110 nuclear receptor subfamily 1 group H member 3 Homo sapiens 63-71 20060389-2 2010 The sterol-responsive transcription factors liver X receptors (LXRalpha and LXRbeta) help maintain cholesterol homeostasis, not only through promotion of cholesterol efflux from peripheral tissues but also through suppression of de novo synthesis and exogenous cholesterol uptake. Cholesterol 154-165 nuclear receptor subfamily 1 group H member 3 Homo sapiens 63-71 20060389-2 2010 The sterol-responsive transcription factors liver X receptors (LXRalpha and LXRbeta) help maintain cholesterol homeostasis, not only through promotion of cholesterol efflux from peripheral tissues but also through suppression of de novo synthesis and exogenous cholesterol uptake. Cholesterol 154-165 nuclear receptor subfamily 1 group H member 3 Homo sapiens 63-71 20419060-1 2010 Peroxisome proliferator-activated receptor gamma1 (PPARgamma1) and liver X receptor alpha (LXRalpha) are nuclear receptors that play pivotal roles in macrophage cholesterol homeostasis and inflammation; key biological processes in atherogenesis. Cholesterol 161-172 nuclear receptor subfamily 1 group H member 3 Homo sapiens 91-99 20419060-2 2010 The activation of PPARgamma1 and LXRalpha by natural or synthetic ligands results in the transactivation of ABCA1, ABCG1, and ApoE; integral players in cholesterol efflux and reverse cholesterol transport. Cholesterol 152-163 nuclear receptor subfamily 1 group H member 3 Homo sapiens 33-41 20419060-2 2010 The activation of PPARgamma1 and LXRalpha by natural or synthetic ligands results in the transactivation of ABCA1, ABCG1, and ApoE; integral players in cholesterol efflux and reverse cholesterol transport. Cholesterol 183-194 nuclear receptor subfamily 1 group H member 3 Homo sapiens 33-41 20419060-5 2010 The specific roles that PPARgamma1 and LXRalpha play in inducing macrophage cholesterol efflux mediators and antagonizing macrophage inflammatory responsiveness are summarized. Cholesterol 76-87 nuclear receptor subfamily 1 group H member 3 Homo sapiens 39-47 18597895-2 2010 Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased oxysterol concentrations may protect neural tissues by activation of liver X receptor-beta (LXR-beta), which induces transcription of genes associated with reduction of cellular cholesterol concentrations and decrease of Abeta formation. Cholesterol 54-65 nuclear receptor subfamily 1 group H member 3 Homo sapiens 187-195 18597895-2 2010 Heme oxygenase-1 (HO-1) stimulates oxidation of glial cholesterol to oxysterols, and increased oxysterol concentrations may protect neural tissues by activation of liver X receptor-beta (LXR-beta), which induces transcription of genes associated with reduction of cellular cholesterol concentrations and decrease of Abeta formation. Cholesterol 273-284 nuclear receptor subfamily 1 group H member 3 Homo sapiens 187-195 18597895-3 2010 Underexpression of HO-1 in concert with underexpression of LXR-beta would result in increased cholesterol accumulation, induction of Abeta production, and increased AD risk. Cholesterol 94-105 nuclear receptor subfamily 1 group H member 3 Homo sapiens 59-67 19798078-1 2010 Liver X receptor-alpha (LXR-alpha), being a member of the nuclear receptor/transcription factor family, has been widely recognized to have a pleiotropic effect in the regulation of genes involved in innate immunity, inflammation and cholesterol homeostasis. Cholesterol 233-244 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-33 20060385-1 2010 The liver X receptors (LXRalpha and LXRbeta) are transcription factors that control the expression of genes primarily involved in cholesterol metabolism. Cholesterol 130-141 nuclear receptor subfamily 1 group H member 3 Homo sapiens 23-31 19168586-1 2009 The oxysterol receptors [liver X receptors (LXRalpha and LXRbeta)] regulate cholesterol and lipid biosynthesis and several studies link dysregulation of these metabolic pathways to aberrant cell growth. Cholesterol 76-87 nuclear receptor subfamily 1 group H member 3 Homo sapiens 44-52 19166963-2 2009 The first event in RCT is internalization of modified low density lipoprotein by macrophages, upon which PPARgamma1 and LXRalpha signaling pathways are turned on, leading to the transactivation of a cascade of genes (e.g. ABCA1 and ABCG1), whose products promote macrophage cholesterol efflux. Cholesterol 274-285 nuclear receptor subfamily 1 group H member 3 Homo sapiens 120-128 19426978-1 2009 AIMS: Liver X receptors alpha and beta (LXRalpha, LXRbeta) are key regulators of cholesterol homeostasis. Cholesterol 81-92 nuclear receptor subfamily 1 group H member 3 Homo sapiens 40-48 19242521-2 2009 Liver X receptor-alpha (LXRalpha) and LXRbeta are nuclear receptors that are activated by oxysterols and regulate cholesterol and fatty acid metabolism. Cholesterol 114-125 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 18676367-4 2008 Here, we show that the nuclear hormone receptor for oxysterols, the liver X receptor alpha (LXRalpha), regulates cholesterol biosynthesis by directly silencing the expression of two key cholesterologenic enzymes (lanosterol 14alpha-demethylase (CYP51A1), and squalene synthase (farnesyl diphosphate farnesyl transferase 1)) via novel negative LXR DNA response elements (nLXREs) located in each of these genes. Cholesterol 113-124 nuclear receptor subfamily 1 group H member 3 Homo sapiens 92-100 19360318-2 2009 LXRalpha regulates cholesterol metabolism as well as fatty acid metabolism, and its agonistic ligands are oxysterols. Cholesterol 19-30 nuclear receptor subfamily 1 group H member 3 Homo sapiens 0-8 19360318-10 2009 Overproduction of cholesterol may lead to an increased level of oxysterols, activation of LXRalpha and SREBP-1c, and enhanced fatty acid synthesis. Cholesterol 18-29 nuclear receptor subfamily 1 group H member 3 Homo sapiens 90-98 18815215-1 2008 The nuclear hormone receptors liver X receptor alpha (LXRalpha) and LXRbeta function as physiological receptors for oxidized cholesterol metabolites (oxysterols) and regulate several aspects of cholesterol and lipid metabolism. Cholesterol 125-136 nuclear receptor subfamily 1 group H member 3 Homo sapiens 54-62 18815215-1 2008 The nuclear hormone receptors liver X receptor alpha (LXRalpha) and LXRbeta function as physiological receptors for oxidized cholesterol metabolites (oxysterols) and regulate several aspects of cholesterol and lipid metabolism. Cholesterol 125-136 nuclear receptor subfamily 1 group H member 3 Homo sapiens 68-75 18815215-1 2008 The nuclear hormone receptors liver X receptor alpha (LXRalpha) and LXRbeta function as physiological receptors for oxidized cholesterol metabolites (oxysterols) and regulate several aspects of cholesterol and lipid metabolism. Cholesterol 194-205 nuclear receptor subfamily 1 group H member 3 Homo sapiens 54-62 18815215-1 2008 The nuclear hormone receptors liver X receptor alpha (LXRalpha) and LXRbeta function as physiological receptors for oxidized cholesterol metabolites (oxysterols) and regulate several aspects of cholesterol and lipid metabolism. Cholesterol 194-205 nuclear receptor subfamily 1 group H member 3 Homo sapiens 68-75 19797938-0 2009 Niacin promotes cholesterol efflux through stimulation of the PPARgamma-LXRalpha-ABCA1 pathway in 3T3-L1 adipocytes. Cholesterol 16-27 nuclear receptor subfamily 1 group H member 3 Homo sapiens 72-80 19797938-8 2009 CONCLUSIONS: Niacin may promote cholesterol efflux from adipocytes to ApoA-I via activation of the PPARgamma-LXRalpha-ABCA1 pathway. Cholesterol 32-43 nuclear receptor subfamily 1 group H member 3 Homo sapiens 109-117 18676367-6 2008 Thus, these data suggest that LXRalpha plays an important role in the regulation of cholesterol biosynthesis. Cholesterol 84-95 nuclear receptor subfamily 1 group H member 3 Homo sapiens 30-38 18081155-2 2008 Liver X receptor-beta (LXRbeta) is a transcription factor that controls expression of genes involved in brain cholesterol metabolism, and one of the main LXRbeta targets is APOE. Cholesterol 110-121 nuclear receptor subfamily 1 group H member 3 Homo sapiens 23-30 18081155-2 2008 Liver X receptor-beta (LXRbeta) is a transcription factor that controls expression of genes involved in brain cholesterol metabolism, and one of the main LXRbeta targets is APOE. Cholesterol 110-121 nuclear receptor subfamily 1 group H member 3 Homo sapiens 154-161 17845217-1 2007 The nuclear receptors liver X receptor alpha (LXRalpha) and liver X-receptor beta (LXRbeta) have a well documented role in cholesterol homeostasis and lipid metabolism within tissues and cells including the liver, small intestine and macrophages. Cholesterol 123-134 nuclear receptor subfamily 1 group H member 3 Homo sapiens 46-54 18328805-0 2008 alpha-Tocopherol disturbs macrophage LXRalpha regulation of ABCA1/G1 and cholesterol handling. Cholesterol 73-84 nuclear receptor subfamily 1 group H member 3 Homo sapiens 37-45 18328805-2 2008 As specific oxylipids activate PPARgamma and LXRalpha, master regulators of lipid metabolism and cholesterol exporters, we hypothesized, that high dose alpha-tocopherol might interfere with reverse cholesterol transport out of the vessel wall. Cholesterol 97-108 nuclear receptor subfamily 1 group H member 3 Homo sapiens 45-53 18328805-2 2008 As specific oxylipids activate PPARgamma and LXRalpha, master regulators of lipid metabolism and cholesterol exporters, we hypothesized, that high dose alpha-tocopherol might interfere with reverse cholesterol transport out of the vessel wall. Cholesterol 198-209 nuclear receptor subfamily 1 group H member 3 Homo sapiens 45-53 18209740-8 2008 CONCLUSIONS: These results suggest that NR1H3 plays an important role in the HDL-cholesterol metabolism and in the genetic susceptibility to metabolic syndrome. Cholesterol 81-92 nuclear receptor subfamily 1 group H member 3 Homo sapiens 40-45 18086530-12 2008 Transcription factor profiling shows that several key nuclear receptors involving cholesterol metabolism were significantly altered in AD brain, including decreased LXR-beta, PPAR and TR, and increased RXR. Cholesterol 82-93 nuclear receptor subfamily 1 group H member 3 Homo sapiens 165-173 18007013-5 2008 The mRNA levels of ABCG5, ABCG8, and liver X receptor alpha (LXRalpha) in the gallstone patients were increased by 51, 59, and 102%, respectively, and significantly correlated with the molar percentage of biliary cholesterol and cholesterol saturation index (CSI). Cholesterol 213-224 nuclear receptor subfamily 1 group H member 3 Homo sapiens 61-69 18007013-5 2008 The mRNA levels of ABCG5, ABCG8, and liver X receptor alpha (LXRalpha) in the gallstone patients were increased by 51, 59, and 102%, respectively, and significantly correlated with the molar percentage of biliary cholesterol and cholesterol saturation index (CSI). Cholesterol 229-240 nuclear receptor subfamily 1 group H member 3 Homo sapiens 61-69 18007013-8 2008 Our results suggest that the upregulation of ABCG5/ABCG8 in gallstone patients, possibly mediated by increased LXRalpha, may contribute to the cholesterol supersaturation of bile. Cholesterol 143-154 nuclear receptor subfamily 1 group H member 3 Homo sapiens 111-119 18024509-2 2008 Utilization of a hidden Markov model for predictive modeling of nuclear hormone receptor response elements coupled with chromatin immunoprecipitation/microarray technology revealed a putative binding site in the AKR1C4 promoter for the nuclear hormone receptor known as liver X receptor alpha, (LXRalpha [NR1H3]), which is the physiological receptor for oxidized cholesterol metabolites. Cholesterol 363-374 nuclear receptor subfamily 1 group H member 3 Homo sapiens 295-303 18024509-2 2008 Utilization of a hidden Markov model for predictive modeling of nuclear hormone receptor response elements coupled with chromatin immunoprecipitation/microarray technology revealed a putative binding site in the AKR1C4 promoter for the nuclear hormone receptor known as liver X receptor alpha, (LXRalpha [NR1H3]), which is the physiological receptor for oxidized cholesterol metabolites. Cholesterol 363-374 nuclear receptor subfamily 1 group H member 3 Homo sapiens 305-310 18427282-9 2008 LXRalpha agonists (T01901317 and 22(R)-hydroxycholesterol) prevented any reductions in cholesterol efflux or ABCA1 expression associated with atorvastatin treatment. Cholesterol 46-57 nuclear receptor subfamily 1 group H member 3 Homo sapiens 0-8 17396233-1 2007 The liver X receptors (LXRalpha and LXRbeta), ligand-activated transcription factors, belong to the superfamily of nuclear hormone receptors and have been shown to play a major role in atherosclerosis by modulating cholesterol and triglyceride metabolism. Cholesterol 215-226 nuclear receptor subfamily 1 group H member 3 Homo sapiens 23-31 17430244-1 2007 Liver X receptors (LXRalpha and LXRbeta) are oxysterol receptors that function as master transcription factors mediating cholesterol homeostasis in the periphery. Cholesterol 121-132 nuclear receptor subfamily 1 group H member 3 Homo sapiens 19-27 17405904-2 2007 We show here that primary hASM cells express liver X receptor (LXR; alpha and beta subtypes), an oxysterol-activated nuclear receptor that controls expression of genes involved in lipid and cholesterol homeostasis, and inflammation. Cholesterol 190-201 nuclear receptor subfamily 1 group H member 3 Homo sapiens 63-73 17088262-11 2007 Rifampicin, 27-HOC, and a potent LXRalpha agonist, T0901317, induced ABCA1 and ABCG1 protein expression and stimulated cholesterol efflux from intestine cells to apolipoprotein A-I and HDL. Cholesterol 119-130 nuclear receptor subfamily 1 group H member 3 Homo sapiens 33-41 17088262-12 2007 This study suggests an intestine-specific PXR/CYP27A1/LXRalpha pathway that regulates intestine cholesterol efflux and HDL assembly. Cholesterol 96-107 nuclear receptor subfamily 1 group H member 3 Homo sapiens 54-62 16973760-1 2007 The nuclear hormone receptors liver X receptor alpha (LXRalpha) (NR1H3) and LXRbeta (NR1H2) are established regulators of cholesterol, lipid, and glucose metabolism and are attractive drug targets for the treatment of diabetes and cardiovascular disease. Cholesterol 122-133 nuclear receptor subfamily 1 group H member 3 Homo sapiens 54-62 16973760-1 2007 The nuclear hormone receptors liver X receptor alpha (LXRalpha) (NR1H3) and LXRbeta (NR1H2) are established regulators of cholesterol, lipid, and glucose metabolism and are attractive drug targets for the treatment of diabetes and cardiovascular disease. Cholesterol 122-133 nuclear receptor subfamily 1 group H member 3 Homo sapiens 65-70 17626048-1 2007 The nuclear receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) are attractive drug targets for the treatment of diabetes and cardiovascular disease due to their established role as regulators of cholesterol and lipid metabolism. Cholesterol 191-202 nuclear receptor subfamily 1 group H member 3 Homo sapiens 22-30 17217555-4 2007 The LXRalpha gene was sequenced in thirty-five French-Canadian men with high plasma total cholesterol (>5.0 mmol/l) and LDL-cholesterol (>3.5 mmol/l) concentrations. Cholesterol 90-101 nuclear receptor subfamily 1 group H member 3 Homo sapiens 4-12 17217555-4 2007 The LXRalpha gene was sequenced in thirty-five French-Canadian men with high plasma total cholesterol (>5.0 mmol/l) and LDL-cholesterol (>3.5 mmol/l) concentrations. Cholesterol 127-138 nuclear receptor subfamily 1 group H member 3 Homo sapiens 4-12 17217555-12 2007 Similar results were observed for c.-840C>A and c.-1830T>C. These results suggest that cholesterol intake interacts with LXRalpha variants to modulate the plasma lipid profile. Cholesterol 93-104 nuclear receptor subfamily 1 group H member 3 Homo sapiens 127-135 17626048-1 2007 The nuclear receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) are attractive drug targets for the treatment of diabetes and cardiovascular disease due to their established role as regulators of cholesterol and lipid metabolism. Cholesterol 191-202 nuclear receptor subfamily 1 group H member 3 Homo sapiens 32-37 17055780-1 2006 The nuclear liver X receptors (LXRalpha and beta) are regulators of lipid and cholesterol metabolism. Cholesterol 78-89 nuclear receptor subfamily 1 group H member 3 Homo sapiens 31-39 16106052-7 2005 Cholesterol-mediated stimulation of CETP involves the transcription factor liver X receptor alpha (LXRalpha). Cholesterol 0-11 nuclear receptor subfamily 1 group H member 3 Homo sapiens 99-107 16920108-1 2006 Liver X receptor alpha (LXRalpha) is a member of the nuclear receptor superfamily that is activated by oxysterols, and plays a pivotal role in regulating the metabolism, transport and uptake of cholesterol. Cholesterol 194-205 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 16920108-2 2006 Here, we demonstrate that LXRalpha also regulates the low-density lipoprotein receptor (LDLR) gene, which mediates the endocytic uptake of LDL cholesterol in the liver. Cholesterol 143-154 nuclear receptor subfamily 1 group H member 3 Homo sapiens 26-34 16920108-5 2006 These results suggest a novel pathway whereby LXRalpha might modulate cholesterol metabolism. Cholesterol 70-81 nuclear receptor subfamily 1 group H member 3 Homo sapiens 46-54 16414355-2 2006 The nuclear receptors peroxisome proliferator-activated receptor alpha (PPARalpha) and liver X receptors (LXRalpha and LXRbeta) are major regulators of cholesterol homeostasis and their activation results in a reduced absorption of intestinal cholesterol. Cholesterol 152-163 nuclear receptor subfamily 1 group H member 3 Homo sapiens 106-114 16414355-2 2006 The nuclear receptors peroxisome proliferator-activated receptor alpha (PPARalpha) and liver X receptors (LXRalpha and LXRbeta) are major regulators of cholesterol homeostasis and their activation results in a reduced absorption of intestinal cholesterol. Cholesterol 243-254 nuclear receptor subfamily 1 group H member 3 Homo sapiens 106-114 16956579-2 2006 LXRalpha and PPARalpha regulate genes involved in cholesterol metabolism and the inflammatory response in macrophages. Cholesterol 50-61 nuclear receptor subfamily 1 group H member 3 Homo sapiens 0-8 16106052-9 2005 Therefore, we present evidence for the first time that inhibition of LXRalpha expression by a high-fat MUFA diet leads to inhibition of CETP stimulation by cholesterol. Cholesterol 156-167 nuclear receptor subfamily 1 group H member 3 Homo sapiens 69-77 12633677-1 2003 The liver X receptors (LXRalpha and LXRbeta) are nuclear receptor transcription factors that are activated by certain oxysterol derivatives of cholesterol. Cholesterol 143-154 nuclear receptor subfamily 1 group H member 3 Homo sapiens 23-31 15725701-5 2005 LXRalpha and LXRbeta, a second oxysterol receptor, regulate intestinal absorption and biliary excretion of cholesterol by inducing target gene expression. Cholesterol 107-118 nuclear receptor subfamily 1 group H member 3 Homo sapiens 0-8 15514210-1 2004 OBJECTIVE: Cholesterol efflux from macrophages in the artery wall, a key cardioprotective mechanism, is largely coordinated by the nuclear oxysterol-activated liver X receptor, LXRalpha. Cholesterol 11-22 nuclear receptor subfamily 1 group H member 3 Homo sapiens 177-185 15503871-1 2004 The liver X receptors (LXRs), LXRalpha and LXRbeta, are ligand-activated transcription factors of the nuclear receptor superfamily that control the expression of genes involved in cholesterol and fatty acid metabolism. Cholesterol 180-191 nuclear receptor subfamily 1 group H member 3 Homo sapiens 30-38 12819202-2 2003 Together with its isoform LXRalpha (NR1H3) it regulates target genes involved in metabolism and transport of cholesterol and fatty acids. Cholesterol 109-120 nuclear receptor subfamily 1 group H member 3 Homo sapiens 26-34 12819202-2 2003 Together with its isoform LXRalpha (NR1H3) it regulates target genes involved in metabolism and transport of cholesterol and fatty acids. Cholesterol 109-120 nuclear receptor subfamily 1 group H member 3 Homo sapiens 36-41 12773300-3 2003 In addition, the nuclear hormone receptors liver X receptor (LXR)alpha and retinoid X receptor (RXR) mediate both AP and BL cholesterol efflux. Cholesterol 124-135 nuclear receptor subfamily 1 group H member 3 Homo sapiens 61-70 15625283-1 2005 OBJECTIVE: Liver X-activated receptor alpha (LXRalpha) regulates multiple genes controlling cholesterol metabolism and transport. Cholesterol 92-103 nuclear receptor subfamily 1 group H member 3 Homo sapiens 45-53 14993933-1 2004 Liver X receptor alpha (LXRalpha) and liver X receptor beta(LXRbeta are oxysterol receptors that regulate multiple target genes involved in cholesterol homeostasis. Cholesterol 140-151 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 14993933-1 2004 Liver X receptor alpha (LXRalpha) and liver X receptor beta(LXRbeta are oxysterol receptors that regulate multiple target genes involved in cholesterol homeostasis. Cholesterol 140-151 nuclear receptor subfamily 1 group H member 3 Homo sapiens 60-67 15299184-1 2004 The liver X> or = receptor alpha (LXRalpha) is a nuclear receptor with a key role in bile acid biosynthesis and cholesterol metabolism. Cholesterol 115-126 nuclear receptor subfamily 1 group H member 3 Homo sapiens 37-45 15299184-8 2004 The importance of LXRalpha signaling in cholesterol homeostasis and the observed expression of LXRalpha in normal breast tissue suggest that this nuclear oxysterol receptor has an important physiological function in the breast. Cholesterol 40-51 nuclear receptor subfamily 1 group H member 3 Homo sapiens 18-26 12893846-4 2003 In this study, we identified the first nonoxysterol natural product that functions as a ligand for the liver X receptor (LXRalpha and LXRbeta; NR1H3, NR1H2), a NHR that acts as the receptor for oxysterols and plays a key role in regulation of cholesterol metabolism and transport as well as glucose metabolism. Cholesterol 243-254 nuclear receptor subfamily 1 group H member 3 Homo sapiens 121-129 12893846-4 2003 In this study, we identified the first nonoxysterol natural product that functions as a ligand for the liver X receptor (LXRalpha and LXRbeta; NR1H3, NR1H2), a NHR that acts as the receptor for oxysterols and plays a key role in regulation of cholesterol metabolism and transport as well as glucose metabolism. Cholesterol 243-254 nuclear receptor subfamily 1 group H member 3 Homo sapiens 143-148 12801525-3 2003 Based upon these and our earlier results, we propose a molecular cross-talk pathway between cholesterol-specific cell surface Receptor-C(k) and nuclear receptors (LxR-alpha and PPAR-gamma), which may add a new dimension in the understanding and control of leukemogenesis. Cholesterol 92-103 nuclear receptor subfamily 1 group H member 3 Homo sapiens 163-172 12904258-1 2003 Liver X activated receptor alpha (LXRalpha) forms a functional dimeric nuclear receptor with RXR that regulates the metabolism of several important lipids, including cholesterol and bile acids. Cholesterol 166-177 nuclear receptor subfamily 1 group H member 3 Homo sapiens 34-42 12554795-1 2003 In rodent liver, transcription of the gene encoding cholesterol 7alpha-hydroxylase (CYP7A1), which catalyzes the rate-limiting step in the classic bile acid synthetic pathway, is stimulated by the liver X receptor alpha (LXRalpha), a nuclear receptor for oxysterol metabolites of cholesterol. Cholesterol 52-63 nuclear receptor subfamily 1 group H member 3 Homo sapiens 221-229 12193599-1 2002 Recent studies have identified the liver X receptors (LXRalpha and LXRbeta) as important regulators of cholesterol and lipid metabolism. Cholesterol 103-114 nuclear receptor subfamily 1 group H member 3 Homo sapiens 54-62 12441342-2 2003 Lipid homeostasis and cholesterol metabolism also are regulated by the nuclear oxysterol receptors, liver X receptors alpha and beta (LXRalpha and LXRbeta). Cholesterol 22-33 nuclear receptor subfamily 1 group H member 3 Homo sapiens 134-142 12595494-9 2003 Taken together with previous data, it appears that, in addition to increasing lipid uptake, inflammatory cytokines promote intracellular lipid accumulation by inhibiting cholesterol efflux through the PPAR-LXRalpha-ABCA1 pathway. Cholesterol 170-181 nuclear receptor subfamily 1 group H member 3 Homo sapiens 206-214 12193651-1 2002 Recent studies have identified the liver X receptors (LXR alpha and LXR beta) as important regulators of cholesterol metabolism and transport. Cholesterol 105-116 nuclear receptor subfamily 1 group H member 3 Homo sapiens 54-63 11969205-4 2002 Downregulation of cholesterol synthesis via the SREBP/SCAP regulatory pathway is common to the initial hydroxycholesterols, but more variations exist with respect to these intermediates functioning as ligands for the nuclear receptor LXRalpha. Cholesterol 18-29 nuclear receptor subfamily 1 group H member 3 Homo sapiens 234-242 14993353-3 2002 In particular, the liver X receptors, LXRalpha and LXRbeta, appear to serve as key sensors of intracellular sterol levels by regulating the expression of genes that control cholesterol absorption, storage, transport, and elimination. Cholesterol 173-184 nuclear receptor subfamily 1 group H member 3 Homo sapiens 38-46 11790787-1 2002 The nuclear receptors LXRalpha and LXRbeta have been implicated in the control of lipogenesis and cholesterol homeostasis. Cholesterol 98-109 nuclear receptor subfamily 1 group H member 3 Homo sapiens 22-30 11875109-9 2002 This would lead to increased hLXRalpha levels and transcription of its downstream target genes such as ABCA1, providing a simple yet exquisite mechanism for cells to respond to LXR ligands and cholesterol loading. Cholesterol 193-204 nuclear receptor subfamily 1 group H member 3 Homo sapiens 29-38 11254888-3 2001 Both FXR and LXRalpha; are thought to play a major role in the control of cholesterol catabolism by regulating the expression of cholesterol 7alpha-hydroxylase, the rate limiting enzyme of bile acid synthesis. Cholesterol 74-85 nuclear receptor subfamily 1 group H member 3 Homo sapiens 13-21 11354255-3 2001 Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8. Cholesterol 52-63 nuclear receptor subfamily 1 group H member 3 Homo sapiens 312-321 11354255-3 2001 Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8. Cholesterol 120-131 nuclear receptor subfamily 1 group H member 3 Homo sapiens 312-321 11354255-3 2001 Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8. Cholesterol 120-131 nuclear receptor subfamily 1 group H member 3 Homo sapiens 312-321 11354255-3 2001 Recent studies have revealed that cells possess two cholesterol-sensors: (a) Receptor-Ck which senses the extracellular cholesterol and initiates signalling pathway responsible for the regulation of genes involved in the cell cycle, cell death, cellular cholesterol homeostasis and cytokines including IL-6; (b) LxR alpha which senses intracellular oxysterols and controls genes involved in cell death, cellular cholesterol homeostasis and cytokine IL-8. Cholesterol 120-131 nuclear receptor subfamily 1 group H member 3 Homo sapiens 312-321 11035776-0 2000 Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Cholesterol 20-31 nuclear receptor subfamily 1 group H member 3 Homo sapiens 73-82 11035776-1 2000 LXR alpha is a nuclear receptor that has previously been shown to regulate the metabolic conversion of cholesterol to bile acids. Cholesterol 103-114 nuclear receptor subfamily 1 group H member 3 Homo sapiens 0-9 10936612-3 2000 Synthetic 6alpha-hydroxylated bile acid analogs were synthesized with LXRalpha-selective agonistic activity, with potential to modulate cholesterol catabolism in hypercholesterolemia. Cholesterol 136-147 nuclear receptor subfamily 1 group H member 3 Homo sapiens 70-78 10360171-6 1999 Finally, we show that ligand-occupied FXR inhibits transactivation from the oxysterol receptor LXR alpha, a positive regulator of cholesterol degradation. Cholesterol 130-141 nuclear receptor subfamily 1 group H member 3 Homo sapiens 95-104 8878485-7 1996 Our results demonstrate the existence of a nuclear receptor signalling pathway for oxysterols and suggest that LXR alpha may be important as a sensor of cholesterol metabolites. Cholesterol 153-164 nuclear receptor subfamily 1 group H member 3 Homo sapiens 111-120 34608806-10 2021 Conclusions: TMF ameliorates cholesterol dysregulation by increasing the expression of FOXO3a/LXRalpha/ABCA1 signaling through SIRT1 in C28/I2 cells. Cholesterol 29-40 nuclear receptor subfamily 1 group H member 3 Homo sapiens 94-102 11741944-1 2002 Liver X receptor alpha (LXRalpha), is a nuclear hormone receptor that is activated by oxysterols and plays a crucial role in regulating cholesterol and lipid metabolism in liver and cholesterol efflux from lipid-loaded macrophages. Cholesterol 136-147 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 11741944-1 2002 Liver X receptor alpha (LXRalpha), is a nuclear hormone receptor that is activated by oxysterols and plays a crucial role in regulating cholesterol and lipid metabolism in liver and cholesterol efflux from lipid-loaded macrophages. Cholesterol 182-193 nuclear receptor subfamily 1 group H member 3 Homo sapiens 24-32 11741331-1 2001 Expression of the LXRalpha nuclear receptor in liver is predicted to affect cholesterol and lipid metabolism. Cholesterol 76-87 nuclear receptor subfamily 1 group H member 3 Homo sapiens 18-26 11546778-1 2001 The nuclear oxysterol receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) coordinately regulate the expression of genes involved in the transport and catabolism of cholesterol. Cholesterol 159-170 nuclear receptor subfamily 1 group H member 3 Homo sapiens 32-40 11546778-1 2001 The nuclear oxysterol receptors LXRalpha (NR1H3) and LXRbeta (NR1H2) coordinately regulate the expression of genes involved in the transport and catabolism of cholesterol. Cholesterol 159-170 nuclear receptor subfamily 1 group H member 3 Homo sapiens 42-47 11546778-7 2001 We conclude that LXRalpha regulates its own expression in human macrophages and that this response is likely to amplify the effects of oxysterols on reverse cholesterol transport. Cholesterol 157-168 nuclear receptor subfamily 1 group H member 3 Homo sapiens 17-25 11035776-5 2000 We further demonstrate that expression of LXR alpha in NIH 3T3 fibroblasts and/or treatment of these cells with oxysterols is sufficient to stimulate cholesterol efflux to extracellular apolipoprotein AI. Cholesterol 150-161 nuclear receptor subfamily 1 group H member 3 Homo sapiens 42-51 9874807-1 1999 LXRalpha and -beta are nuclear receptors that regulate the metabolism of several important lipids, including cholesterol and bile acids. Cholesterol 109-120 nuclear receptor subfamily 1 group H member 3 Homo sapiens 0-8 34608501-12 2021 Mechanistically, exosomal-mediated delivery of si-LOC100129516 promoted cholesterol efflux by activating the peroxisome proliferator-activated receptor gamma (PPARgamma)/liver X receptor alpha (LXRalpha)/phospholipid-transporting ATPase ABCA1 (ABCA1) signaling pathway in vitro and in vivo. Cholesterol 72-83 nuclear receptor subfamily 1 group H member 3 Homo sapiens 194-202