PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19066129-0 2008 Amentoflavone stimulates apoptosis in B16F-10 melanoma cells by regulating bcl-2, p53 as well as caspase-3 genes and regulates the nitric oxide as well as proinflammatory cytokine production in B16F-10 melanoma cells, tumor associated macrophages and peritoneal macrophages. amentoflavone 0-13 caspase 3 Mus musculus 97-106 19066129-5 2008 Furthermore, amentoflavone showed inhibitory effect on bcl-2 expression and upregulated p53 and caspase-3 gene expression in B16F-10 melanoma cells. amentoflavone 13-26 caspase 3 Mus musculus 96-105 19066129-6 2008 In conclusion, the observed results suggests that, amentoflavone stimulates apoptosis by regulating bcl-2, Caspase-3 and p53 genes in B16F-10 melanoma cells and regulates nitric oxide and proinflammatory cytokine production in B16F-10 cells, TAMs and peritoneal macrophages. amentoflavone 51-64 caspase 3 Mus musculus 107-116 16336627-5 2006 Amentoflavone blocked the activation of caspase 3, characteristic of apoptosis, and the proteolytic cleavage of its substrates following H-I injury. amentoflavone 0-13 caspase 3 Mus musculus 40-49