PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24553921-2 2014 Mutations in acyl-CoA synthetase long-chain family member 4 (ACSL4), which converts long-chain fatty acids to acyl-CoAs, result in nonsyndromic X-linked mental retardation. Acyl Coenzyme A 110-119 acyl-CoA synthetase long chain family member 4 Homo sapiens 61-66 31789401-1 2020 Acyl-CoA synthetase long-chain family member 4 (ACSL4) is a member of the long chain family of acyl-CoA synthetase proteins, which have recently been shown to serve an important role in ferroptosis. Acyl Coenzyme A 95-103 acyl-CoA synthetase long chain family member 4 Homo sapiens 0-46 31789401-1 2020 Acyl-CoA synthetase long-chain family member 4 (ACSL4) is a member of the long chain family of acyl-CoA synthetase proteins, which have recently been shown to serve an important role in ferroptosis. Acyl Coenzyme A 95-103 acyl-CoA synthetase long chain family member 4 Homo sapiens 48-53 33077484-7 2021 ACSL4 regulated a broad spectrum of fatty acyl-CoA levels, and its catalytic efficiency in fatty acyl-CoAs biosynthesis was about 1.9-4.3-fold higher than ACSL3. Acyl Coenzyme A 42-50 acyl-CoA synthetase long chain family member 4 Homo sapiens 0-5 33077484-7 2021 ACSL4 regulated a broad spectrum of fatty acyl-CoA levels, and its catalytic efficiency in fatty acyl-CoAs biosynthesis was about 1.9-4.3-fold higher than ACSL3. Acyl Coenzyme A 97-106 acyl-CoA synthetase long chain family member 4 Homo sapiens 0-5 33077484-10 2021 Our results suggest that the surge of ACSL4 levels by targeting AR signaling increases fatty acyl-CoAs biosynthesis and protein myristoylation, indicating the opposite yet complementary or Yin-Yang regulation of ACSL3 and 4 levels in sustaining fatty acid metabolism when targeting androgen-AR signaling. Acyl Coenzyme A 87-102 acyl-CoA synthetase long chain family member 4 Homo sapiens 38-43 22808264-1 2012 The acyl-CoA synthetase 4 (ACSL4), which esterify mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and hepatocellular carcinoma. Acyl Coenzyme A 4-12 acyl-CoA synthetase long chain family member 4 Homo sapiens 27-32 21307243-1 2011 Acyl-CoA synthetase long-chain family member 4 (ACSL4) converts long-chain fatty acids to acyl-CoAs that are indispensable for lipid metabolism and cell signaling. Acyl Coenzyme A 90-99 acyl-CoA synthetase long chain family member 4 Homo sapiens 48-53 12163649-4 2002 ACS4 may provide acyl-CoA for both synthesis and peroxisomal oxidation, depending on whether the enzyme is associated with the mitochondrial-associated membrane or with peroxisomes. Acyl Coenzyme A 17-25 acyl-CoA synthetase long chain family member 4 Homo sapiens 0-4 35103282-1 2022 Acyl-CoA synthetase long-chain family member 4 (ACSL4) activates polyunsaturated fatty acids (PUFAs) to produce PUFA-derived acyl-CoAs, which are utilised for the synthesis of various biological components, including phospholipids (PL). Acyl Coenzyme A 125-134 acyl-CoA synthetase long chain family member 4 Homo sapiens 0-46 35103282-1 2022 Acyl-CoA synthetase long-chain family member 4 (ACSL4) activates polyunsaturated fatty acids (PUFAs) to produce PUFA-derived acyl-CoAs, which are utilised for the synthesis of various biological components, including phospholipids (PL). Acyl Coenzyme A 125-134 acyl-CoA synthetase long chain family member 4 Homo sapiens 48-53 35103282-3 2022 In the present study, we investigated the effects of ACSL4 knockdown on the levels of acyl-CoA, PL, and ferroptosis in the human normal kidney proximal tubule epithelial (HK-2) cells. Acyl Coenzyme A 86-94 acyl-CoA synthetase long chain family member 4 Homo sapiens 53-58 35103282-4 2022 LC-MS/MS analyses revealed that the knockdown of ACSL4 markedly reduced the levels of PUFA-derived acyl-CoA, but not those of other acyl-CoAs. Acyl Coenzyme A 99-107 acyl-CoA synthetase long chain family member 4 Homo sapiens 49-54