PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16107549-2 2005 Evidence indicates that PBDE mixtures induce CYPs through aryl hydrocarbon receptor (AhR)-dependent and -independent pathways. Halogenated Diphenyl Ethers 24-28 aryl hydrocarbon receptor Rattus norvegicus 58-83 16107549-2 2005 Evidence indicates that PBDE mixtures induce CYPs through aryl hydrocarbon receptor (AhR)-dependent and -independent pathways. Halogenated Diphenyl Ethers 24-28 aryl hydrocarbon receptor Rattus norvegicus 85-88 16107549-3 2005 The present work has investigated the effects of individual components of a commercial PBDE mixture (DE71) on expression of CYP1A1, a biomarker for activation of the AhR (dioxin-like), and CYP2B and CYP3A, biomarkers for activation of the constitutive androstane and pregnanexreceptors (CAR and PXR), respectively, in the rat. Halogenated Diphenyl Ethers 87-91 aryl hydrocarbon receptor Rattus norvegicus 166-169 16107549-10 2005 These results indicate that in vivo PBDE-mediated toxicity would be better categorized by AhR-independent mechanisms, rather than the well-characterized AhR-dependent mechanism associated with exposure to dioxin-like chemicals. Halogenated Diphenyl Ethers 36-40 aryl hydrocarbon receptor Rattus norvegicus 90-93