PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20544555-4	2010	It was found that some of the PBDE compounds with antiestrogenic activity extended into the channel of the estrogen receptor (ER), which is usually occupied by the alkylamine side chain of the ER antagonists raloxifene (RAL) and 4-hydroxytamoxifen (OHT), while most PBDE compounds without antiestrogenic activity adopted binding modes similar to that of ER agonist 17beta-estradiol (E2), located in the binding cavity and which did not protrude into the channel.	Halogenated Diphenyl Ethers	266-270	estrogen receptor 1	Homo sapiens	107-124	
20544555-0	2010	Exploring the binding features of polybrominated diphenyl ethers as estrogen receptor antagonists: docking studies.	Halogenated Diphenyl Ethers	34-64	estrogen receptor 1	Homo sapiens	68-85	
20544555-4	2010	It was found that some of the PBDE compounds with antiestrogenic activity extended into the channel of the estrogen receptor (ER), which is usually occupied by the alkylamine side chain of the ER antagonists raloxifene (RAL) and 4-hydroxytamoxifen (OHT), while most PBDE compounds without antiestrogenic activity adopted binding modes similar to that of ER agonist 17beta-estradiol (E2), located in the binding cavity and which did not protrude into the channel.	Halogenated Diphenyl Ethers	30-34	estrogen receptor 1	Homo sapiens	107-124	
20544555-4	2010	It was found that some of the PBDE compounds with antiestrogenic activity extended into the channel of the estrogen receptor (ER), which is usually occupied by the alkylamine side chain of the ER antagonists raloxifene (RAL) and 4-hydroxytamoxifen (OHT), while most PBDE compounds without antiestrogenic activity adopted binding modes similar to that of ER agonist 17beta-estradiol (E2), located in the binding cavity and which did not protrude into the channel.	Halogenated Diphenyl Ethers	30-34	estrogen receptor 1	Homo sapiens	126-128	
20544555-4	2010	It was found that some of the PBDE compounds with antiestrogenic activity extended into the channel of the estrogen receptor (ER), which is usually occupied by the alkylamine side chain of the ER antagonists raloxifene (RAL) and 4-hydroxytamoxifen (OHT), while most PBDE compounds without antiestrogenic activity adopted binding modes similar to that of ER agonist 17beta-estradiol (E2), located in the binding cavity and which did not protrude into the channel.	Halogenated Diphenyl Ethers	266-270	estrogen receptor 1	Homo sapiens	126-128	
12389923-1	2002	This study examined the ability of environmentally relevant concentrations of 10 different polybrominated diphenyl ethers (PBDEs) to induce aryl hydrocarbon receptor (AhR)- and estrogen receptor (ER)-mediated gene expression in vitro.	Halogenated Diphenyl Ethers	91-121	estrogen receptor 1	Homo sapiens	177-194	
12389923-1	2002	This study examined the ability of environmentally relevant concentrations of 10 different polybrominated diphenyl ethers (PBDEs) to induce aryl hydrocarbon receptor (AhR)- and estrogen receptor (ER)-mediated gene expression in vitro.	Halogenated Diphenyl Ethers	91-121	estrogen receptor 1	Homo sapiens	196-198	
12389923-1	2002	This study examined the ability of environmentally relevant concentrations of 10 different polybrominated diphenyl ethers (PBDEs) to induce aryl hydrocarbon receptor (AhR)- and estrogen receptor (ER)-mediated gene expression in vitro.	Halogenated Diphenyl Ethers	123-128	estrogen receptor 1	Homo sapiens	177-194	
12389923-1	2002	This study examined the ability of environmentally relevant concentrations of 10 different polybrominated diphenyl ethers (PBDEs) to induce aryl hydrocarbon receptor (AhR)- and estrogen receptor (ER)-mediated gene expression in vitro.	Halogenated Diphenyl Ethers	123-128	estrogen receptor 1	Homo sapiens	196-198	
11335189-9	2001	These results indicate that several pure PBDE congeners, but especially HO-PBDEs and brominated bisphenol A-analogs, are agonists of both ER alpha and ER beta receptors, thus stimulating ER-mediated luciferase induction in vitro.	Halogenated Diphenyl Ethers	41-45	estrogen receptor 1	Homo sapiens	138-146	
23603053-0	2013	Structure-dependent activities of hydroxylated polybrominated diphenyl ethers on human estrogen receptor.	Halogenated Diphenyl Ethers	47-77	estrogen receptor 1	Homo sapiens	87-104	
23603053-1	2013	Polybrominated diphenyl ethers (PBDEs) have been shown to affect the estrogen receptor (ER) signaling pathway, and one of the proposed disruption mechanisms is direct binding of hydroxylated PBDE (OH-PBDE) to ER.	Halogenated Diphenyl Ethers	0-30	estrogen receptor 1	Homo sapiens	69-86	
23603053-1	2013	Polybrominated diphenyl ethers (PBDEs) have been shown to affect the estrogen receptor (ER) signaling pathway, and one of the proposed disruption mechanisms is direct binding of hydroxylated PBDE (OH-PBDE) to ER.	Halogenated Diphenyl Ethers	0-30	estrogen receptor 1	Homo sapiens	88-90	
23603053-1	2013	Polybrominated diphenyl ethers (PBDEs) have been shown to affect the estrogen receptor (ER) signaling pathway, and one of the proposed disruption mechanisms is direct binding of hydroxylated PBDE (OH-PBDE) to ER.	Halogenated Diphenyl Ethers	0-30	estrogen receptor 1	Homo sapiens	209-211	
23603053-1	2013	Polybrominated diphenyl ethers (PBDEs) have been shown to affect the estrogen receptor (ER) signaling pathway, and one of the proposed disruption mechanisms is direct binding of hydroxylated PBDE (OH-PBDE) to ER.	Halogenated Diphenyl Ethers	32-37	estrogen receptor 1	Homo sapiens	69-86	
23603053-1	2013	Polybrominated diphenyl ethers (PBDEs) have been shown to affect the estrogen receptor (ER) signaling pathway, and one of the proposed disruption mechanisms is direct binding of hydroxylated PBDE (OH-PBDE) to ER.	Halogenated Diphenyl Ethers	32-37	estrogen receptor 1	Homo sapiens	88-90	
23603053-1	2013	Polybrominated diphenyl ethers (PBDEs) have been shown to affect the estrogen receptor (ER) signaling pathway, and one of the proposed disruption mechanisms is direct binding of hydroxylated PBDE (OH-PBDE) to ER.	Halogenated Diphenyl Ethers	32-37	estrogen receptor 1	Homo sapiens	209-211