PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31134799-1 2019 The scaffolds of polyketides are constructed via assembly of extender units based on malonyl-CoA and its derivatives that are substituted at the C2-position with diverse chemical functionality. Polyketides 17-28 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Mus musculus 93-96 31134799-3 2019 Yet, a biosensor for the detection of malonyl-CoA derivatives has yet to be reported, severely restricting the application of high-throughput synthetic biology approaches to engineering extender unit biosynthesis and limiting the ability to dynamically regulate the biosynthesis of polyketide products that are dependent on such alpha-carboxyacyl-CoAs. Polyketides 282-292 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Mus musculus 46-49 31134799-6 2019 This FapR promiscuity proved sufficient for the detection of the polyketide extender unit methylmalonyl-CoA in E. coli, providing the first reported genetically encoded biosensor for this important metabolite. Polyketides 65-75 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Mus musculus 104-107