PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22432862-3	2012	Especially important in aromatic polyketide biosynthesis is the regiospecific cyclization of a linear, preassembled polyketide chain catalyzed by aromatase/cyclase (ARO/CYC), which serves as a key control point in aromatic ring formation.	Polyketides	33-43	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	165-168	
26631750-3	2015	The aromatase/cyclases (ARO/CYCs) are responsible for regiospecific cyclization of bacterial polyketides.	Polyketides	93-104	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	24-27	
26631750-10	2015	This work completes the structural and functional characterization of mono- and di-domain ARO/CYCs in bacterial type II polyketide synthases and lays the groundwork for engineered biosynthesis of new bioactive polyketides.	Polyketides	210-221	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	90-93	
22432862-3	2012	Especially important in aromatic polyketide biosynthesis is the regiospecific cyclization of a linear, preassembled polyketide chain catalyzed by aromatase/cyclase (ARO/CYC), which serves as a key control point in aromatic ring formation.	Polyketides	116-126	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	165-168	
18388203-10	2008	The chemical insights gleaned from this work pave the foundation toward defining the molecular rules for the ARO/CYC cyclization specificity, whose rational control will be important for future endeavors in the engineered biosynthesis of novel anticancer and antibiotic aromatic polyketides.	Polyketides	279-290	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	109-112	
21870821-3	2011	The aromatase/cyclases (ARO/CYCs) are an important component of the type II polyketide synthase (PKS) and help fold the polyketide for regiospecific cyclizations of the first ring and/or aromatization, promoting two commonly observed first-ring cyclization patterns for the bacterial type II PKSs: C7-C12 and C9-C14.	Polyketides	76-86	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	24-27	
21870821-6	2011	In this work, we present the 2.4 A crystal structure of ZhuI, a C7-C12-specific first-ring ARO/CYC from the type II PKS pathway responsible for the production of the R1128 polyketides.	Polyketides	172-183	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	91-94