PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9219693-1 1997 A genetic block was introduced in the first condensation step of the polyketide biosynthetic pathway that leads to the formation of 6-deoxyerythronolide B (6-dEB), the macrocyclic precursor of erythromycin. Polyketides 69-79 DebC Drosophila melanogaster 158-161 9219693-2 1997 Exogenous addition of designed synthetic molecules to small-scale cultures of this null mutant resulted in highly selective multimilligram production of unnatural polyketides, including aromatic and ring-expanded variants of 6-dEB. Polyketides 163-174 DebC Drosophila melanogaster 227-230