PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24971706-2	2014	The pestivirus bovine viral diarrhoea virus (BVDV) is a surrogate model for HCV infection and NTZ induced PKR and eIF2alpha phosphorylation in both uninfected and BVDV-infected cells.	nitazoxanide	94-97	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	106-109	
31402258-3	2019	NTZ significantly inhibits EBOV replication in human cells through its effects on RIG-I and protein kinase R (PKR), suggesting that it counteracts EBOV VP35 protein"s ability to block RIG-I and PKR sensing of EBOV.	nitazoxanide	0-3	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	92-108	
31402258-3	2019	NTZ significantly inhibits EBOV replication in human cells through its effects on RIG-I and protein kinase R (PKR), suggesting that it counteracts EBOV VP35 protein"s ability to block RIG-I and PKR sensing of EBOV.	nitazoxanide	0-3	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	110-113	
31402258-3	2019	NTZ significantly inhibits EBOV replication in human cells through its effects on RIG-I and protein kinase R (PKR), suggesting that it counteracts EBOV VP35 protein"s ability to block RIG-I and PKR sensing of EBOV.	nitazoxanide	0-3	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	194-197	
19664635-4	2009	METHODS: We analyzed the effects of NTZ on the regulation of eukaryotic initiation factor-2alpha (eIF2alpha) and its IFN-induced kinase, protein kinase activated by double-stranded RNA (PKR), in cells that support HCV RNA replication and in vitro biochemical assays.	nitazoxanide	36-39	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	186-189	
23553458-5	2013	Similarly to IFN, NTZ increases the activity of the cellular protein kinase activated by double-stranded RNA (PKR), a key kinase in the innate antiviral response.	nitazoxanide	18-21	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	110-113	
23553458-6	2013	In order to elucidate whether sequence heterogeneity in the PKR-binding domain of HCV NS5A genotype 1 could influence the antiviral activity of either NTZ monotherapy or peg-IFN + RBV, baseline and end-of-therapy plasma samples from two groups of eleven non-responder HIV/HCV-coinfected patients that had received NTZ or peg-IFN + RBV were studied.	nitazoxanide	151-154	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	60-63	
23553458-6	2013	In order to elucidate whether sequence heterogeneity in the PKR-binding domain of HCV NS5A genotype 1 could influence the antiviral activity of either NTZ monotherapy or peg-IFN + RBV, baseline and end-of-therapy plasma samples from two groups of eleven non-responder HIV/HCV-coinfected patients that had received NTZ or peg-IFN + RBV were studied.	nitazoxanide	314-317	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	60-63	
19664635-7	2009	NTZ also increased PKR phosphorylation.	nitazoxanide	0-3	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	19-22	
19664635-8	2009	In vitro, NTZ promoted PKR autophosphorylation, a key step in activating PKR"s kinase activity for eIF2alpha.	nitazoxanide	10-13	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	23-26	
19664635-8	2009	In vitro, NTZ promoted PKR autophosphorylation, a key step in activating PKR"s kinase activity for eIF2alpha.	nitazoxanide	10-13	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	73-76	
19664635-9	2009	Finally, NTZ-induced eIF2alpha phosphorylation was reduced in the presence of specific inhibitors of PKR autophosphorylation.	nitazoxanide	9-12	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	101-104	
19664635-10	2009	CONCLUSIONS: An important mechanism of NTZ"s action involves activation of PKR, a key kinase that regulates the cell"s innate antiviral response.	nitazoxanide	39-42	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	75-78