PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32197359-0	2020	Ponatinib Induces Vascular Toxicity through the Notch-1 Signaling Pathway.	ponatinib	0-9	notch receptor 1	Homo sapiens	48-55	
32197359-2	2020	Specific activation of Notch signaling in CML cells by ponatinib can be considered as the "on-target effect" on the tumor and represents a therapeutic approach for CML.	ponatinib	55-64	notch receptor 1	Homo sapiens	23-28	
32197359-7	2020	We delineated the signaling of ponatinib-induced vascular toxicity, demonstrating that ponatinib inhibits endothelial survival, reduces angiogenesis and induces endothelial senescence and apoptosis via the Notch-1 pathway.	ponatinib	31-40	notch receptor 1	Homo sapiens	206-213	
32197359-7	2020	We delineated the signaling of ponatinib-induced vascular toxicity, demonstrating that ponatinib inhibits endothelial survival, reduces angiogenesis and induces endothelial senescence and apoptosis via the Notch-1 pathway.	ponatinib	87-96	notch receptor 1	Homo sapiens	206-213	
32197359-10	2020	By hyperactivating Notch-1 in the vessels, ponatinib exerts an "on-target off tumor effect", which leads to deleterious effects and may explain the drug"s vasculotoxicity.	ponatinib	43-52	notch receptor 1	Homo sapiens	19-26	
32197359-11	2020	Selective blockade of Notch-1 prevented ponatinib-induced vascular toxicity.	ponatinib	40-49	notch receptor 1	Homo sapiens	22-29