PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28427224-0 2017 Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells. ponatinib 0-9 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 45-51 28427224-0 2017 Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells. ponatinib 0-9 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 52-55 28427224-4 2017 The goal of this study was to determine whether ponatinib, an FDA-approved ABL/SRC inhibitor, reduced proliferation and/or survival of merlin-deficient human Schwann cells (HSC). ponatinib 48-57 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 135-141 28427224-7 2017 Ponatinib reduced merlin-deficient HSC viability in a dose-dependent manner by decreasing phosphorylation of PDGFRalpha/beta, AKT, p70S6K, MEK1/2, ERK1/2 and STAT3. ponatinib 0-9 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 18-24 28427224-10 2017 These results suggest that ponatinib is a potential therapeutic agent for NF2-associated schwannomas and warrants further in vivo investigation. ponatinib 27-36 NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor Homo sapiens 74-77