PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31004883-8	2019	Flow cytometry analysis revealed that PAB caused an obvious cell cycle arrest in G2/M phase and induced apoptosis with the induction of p21, Bax, cleaved-caspase-3, and cleaved-PARP in human HepG2 and SK-Hep-1 cells.	pseudolaric acid B	38-41	BCL2 associated X, apoptosis regulator	Homo sapiens	141-144	
31328459-0	2019	Pseudolaric acid B inhibits PAX2 expression through Wnt signaling and induces BAX expression, therefore promoting apoptosis in HeLa cervical cancer cells.	pseudolaric acid B	0-18	BCL2 associated X, apoptosis regulator	Homo sapiens	78-81	
24248012-10	2014	Furthermore, western blot analysis showed that PAB treatment upregulated the protein levels of Bax, Bad and downregulated Bcl-2 and Bcl-xl expression.	pseudolaric acid B	47-50	BCL2 associated X, apoptosis regulator	Homo sapiens	95-98	
15714803-4	2005	Apoptotic bodies and DNA ladder were observed in 5 micromol x L(-1) pseudolaric acid B-treated A375-S2 cells for 36 h. The expression of Bcl-2, Bcl-xL and ICAD was reduced time dependently, whereas the expression of Bax was increased.	pseudolaric acid B	68-86	BCL2 associated X, apoptosis regulator	Homo sapiens	216-219	
20929130-4	2010	CONCLUSION: PAB can inhibit the proliferation and induce the apoptosis of Hela cells in vitro, and its molecular mechanism may be associated with up-regulating bax mRNA expression and down-regulating bcl-2 mRNA expression.	pseudolaric acid B	12-15	BCL2 associated X, apoptosis regulator	Homo sapiens	160-163	
15665588-5	2004	In addition, Bcl-2 expression was down-regulated while Bax protein level was up-regulated.Caspase-3 inhibitor, z-DEVD-fmk, partially blocked pseudolaric acid B-induced cell death, and the expression of two classical caspase substrates,PARP and ICAD, were both decreased in a time-dependent manner, indicative of downstream cas-pase activation.	pseudolaric acid B	141-159	BCL2 associated X, apoptosis regulator	Homo sapiens	55-58	
15742811-0	2005	Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells.	pseudolaric acid B	0-18	BCL2 associated X, apoptosis regulator	Homo sapiens	53-56