PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29741901-7	2018	The computational results reveal that CYP2C19 exclusively metabolizes R-omeprazole to hydroxyomeprazole, which is hydrophilic and can easily excrete, whereas CYP3A4 metabolizes S-omeprazole to lipophilic sulfone; hence, the excretion of this metabolite would be relatively slower from the body.	5-hydroxymethylomeprazole	86-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	158-164	
16338278-9	2005	In contrast, the CYP3A4-dependent formation of omeprazole sulfone increased by 40%, and consequently, the metabolic ratio of omeprazole sulfone to 5-hydroxyomeprazole was elevated from 7.9 to 19.3 (P = .0004).	5-hydroxymethylomeprazole	147-166	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	17-23	
11501187-0	2000	Probing CYP2C19 and CYP3A4 activities in Chinese liver microsomes by quantification of 5-hydroxyomeprazole and omeprazole sulphone.	5-hydroxymethylomeprazole	87-106	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	20-26	
7917780-10	1994	By contrast, CYP3A activities were predominant in the formation of hydroxysulphone from hydroxyomeprazole as well as in the formation of pyridine-N-oxide omeprazole sulphone from omeprazole sulphone.	5-hydroxymethylomeprazole	88-105	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	13-18	
12959268-7	1993	3 Formation of the major metabolite, hydroxyomeprazole, was significantly correlated with S-mephenytoin hydroxylase and with benzo[a]pyrene metabolism and CYP3A content.	5-hydroxymethylomeprazole	37-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	155-160	
12959268-8	1993	Inhibition studies with isoform selective inhibitors also indicated a dominant role of S-mephenytoin hydroxylase with some CYP3A contribution in the formation of hydroxyomeprazole.	5-hydroxymethylomeprazole	162-179	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	123-128	
16791583-1	2006	OBJECTIVE: The hydroxylation of omeprazole, measured as the ratio of omeprazole/5-hydroxyomeprazole in a plasma sample taken 3 h after an oral dose, is an established method to determine CYP2C19 activity, and the ratio of omeprazole AUC/omeprazole sulfone AUC has been used for assessing CYP3A4 activity.	5-hydroxymethylomeprazole	80-99	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	288-294