PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34748042-5 2021 AMPK activators AICAR and A-769662 suppressed the EGF-stimulated phosphorylation of EGFR (Tyr1173) and NKAalpha1 at Tyr10. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 26-34 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 0-4 32470915-4 2020 Functional responses to the selective AMPK activator A769662 were assessed in intrarenal small arteries isolated from the kidney of renal tumour patients and Wistar rats and mounted in microvascular myographs to perform simultaneous measurements of intracellular calcium [Ca2+]i and tension. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 53-60 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 38-42 35254586-6 2022 Moreover, investigation of the effect of AMPK activity on PRRSV replication showed that PRRSV replication could be suppressed by the pharmacological agonists 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and A769662. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 217-224 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 41-45 32470915-6 2020 Activation of AMPK with A769662 increased AMPKalpha phosphorylation at Thr-172 and induced potent relaxations compared to AICAR in isolated human and rat intrarenal arteries, through both endothelium-dependent mechanisms involving nitric oxide (NO) and intermediate-conductance calcium-activated potassium (IKCa) channels, as well as activation of ATP-sensitive (KATP) channels and sarcoplasmic reticulum Ca2+-ATPase (SERCA) in vascular smooth muscle (VSM). 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 24-31 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 14-18 31944615-9 2020 In addition, activation of AMPK by A769662 (an AMPK activator) had similar effects to metformin on human spermatozoa, while inhibition of AMPK by compound C (an AMPK inhibitor) suppressed the enhancement of metformin on human spermatozoa. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 35-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 27-31 31944615-9 2020 In addition, activation of AMPK by A769662 (an AMPK activator) had similar effects to metformin on human spermatozoa, while inhibition of AMPK by compound C (an AMPK inhibitor) suppressed the enhancement of metformin on human spermatozoa. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 35-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 47-51 31944615-9 2020 In addition, activation of AMPK by A769662 (an AMPK activator) had similar effects to metformin on human spermatozoa, while inhibition of AMPK by compound C (an AMPK inhibitor) suppressed the enhancement of metformin on human spermatozoa. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 35-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 47-51 31944615-9 2020 In addition, activation of AMPK by A769662 (an AMPK activator) had similar effects to metformin on human spermatozoa, while inhibition of AMPK by compound C (an AMPK inhibitor) suppressed the enhancement of metformin on human spermatozoa. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 35-42 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 47-51 29623826-7 2019 AMP, 5-Aminoimidazole-4-carboxamide riboside (AICA riboside) and A769662 are important activators of AMPK which have potential therapeutic importance in diabetes and diabetic complications. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 65-72 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 101-105 32323755-8 2020 Both the glycolysis inhibitor 2-deoxy-d-glucose (2DG) and the AMPK activator A-769662 induced the phosphorylation of AMPK, resulting in mTORC1 inhibition, as evidenced by a decrease in the phosphorylation of the target ribosomal protein S6 (RPS6). 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 77-85 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 62-66 32323755-8 2020 Both the glycolysis inhibitor 2-deoxy-d-glucose (2DG) and the AMPK activator A-769662 induced the phosphorylation of AMPK, resulting in mTORC1 inhibition, as evidenced by a decrease in the phosphorylation of the target ribosomal protein S6 (RPS6). 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 77-85 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 117-121 32323755-12 2020 On the whole, the findings of the present study demonstrate, that AMPK activation via 2DG or A-769662 protects astrocytes under hypoxic and glucose-depleted conditions. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 93-101 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 66-70 29623826-11 2019 A769662, a non-nucleoside thienopyridone compound which resulted from the lead optimization studies on A-592107 and several other related compound is reported to exhibit a promising effect on diabetes and its complications through activation of AMPK. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 0-7 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 245-249 29623826-12 2019 Subsequent to the discovery of A769662, several thienopyridones, hydroxybiphenyls pyrrolopyridones have been reported as AMPK modulators. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 31-38 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 121-125 24960362-1 2014 Here we report that 5"-monophosphate (AMP)-activated protein kinase (AMPK) agonist A-769662 inhibited hydrogen peroxide (H2O2)-induced viability loss and apoptosis of human and mouse osteoblast cells. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 83-91 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 69-73 26635351-8 2016 Compared with beta1-containing heterotrimers, beta2-containing AMPK isoforms are less sensitive to activation by A769662, a synthetic activator. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 113-120 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 63-67 25956678-5 2015 This specific TR-FRET assay for AMPK was optimized in the 384-well format and produced similar EC(50) values for AMPK activators AMP and A769662 and a similar IC(50) value for AMPK inhibitor compound C, as previously reported. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 137-144 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 32-36 27121290-6 2016 2DG, an inhibitor of glycolysis, and the AMPK activator A769662 reduced glucose consumption, induced phosphorylation of AMPK and mimicked the effects of low glucose availability on the toxicity of PD153035. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 56-63 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 41-45 27121290-6 2016 2DG, an inhibitor of glycolysis, and the AMPK activator A769662 reduced glucose consumption, induced phosphorylation of AMPK and mimicked the effects of low glucose availability on the toxicity of PD153035. 4-hydroxy-3-(4-(2-hydroxyphenyl)phenyl)-6-oxo-7H-thieno(2,3-b)pyridine-5-carbonitrile 56-63 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 120-124