PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15116089-5 2004 PD173074-mediated inhibition of FGFR activity caused downregulation of cyclin D1 and cyclin D2 expression, inhibition of cyclin D/cdk4 activity and, as a consequence, reduction of pRB phosphorylation. PD 173074 0-8 cyclin D1 Homo sapiens 71-80 15116089-6 2004 Retroviral-mediated ectopic expression of cyclin D1 prevented pRB hypophosphorylation and the cell cycle G1 block in PD173074-treated cells, suggesting a central role for D cyclins in proliferation of FGFR-driven breast cancer cells. PD 173074 117-125 cyclin D1 Homo sapiens 42-51 34933671-12 2021 Furthermore, we found significant correlations of DNA methylation of specific CpG sites with response to the FGFR1/3-selective inhibitors PD 173074 and AZD4547, predominantly within the transcription start site of CCND1. PD 173074 138-147 cyclin D1 Homo sapiens 214-219