PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23053727-0 2013 Neferine inhibits the upregulation of CCL5 and CCR5 in vascular endothelial cells during chronic high glucose treatment. neferine 0-8 C-C motif chemokine receptor 5 Homo sapiens 47-51 23053727-8 2013 The increased level of ROS and elevated expressions of CCL5 and CCR5 at high glucose were significantly inhibited by neferine; meanwhile the decreased NO production upon chronic high glucose treatment was relieved. neferine 117-125 C-C motif chemokine receptor 5 Homo sapiens 64-68 23053727-10 2013 These data indicate that neferine can reduce the upregulation of CCL5 and CCR5 of vascular endothelium exposure to chronic high glucose and prevent or inhibit subsequent occurrence of inflammation in blood vessels possibly through antioxidation. neferine 25-33 C-C motif chemokine receptor 5 Homo sapiens 74-78